Mammalian Development
Author: Patrick P. L. Tam
Publisher:
Published: 2013
Total Pages: 0
ISBN-13: 9781936113248
DOWNLOAD EBOOK"A subject collection from Cold Spring Harbor perspectives in biology."
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Stem Cells and the Future of Regenerative Medicine
Author: Institute of Medicine
Publisher: National Academies Press
Published: 2002-01-25
Total Pages: 112
ISBN-13: 0309170427
DOWNLOAD EBOOKRecent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
Epigenetics and Regeneration
Author:
Publisher: Academic Press
Published: 2019-05-24
Total Pages: 544
ISBN-13: 0128148802
DOWNLOAD EBOOKEpigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics. - Provides a foundational overview of epigenetics in regenerative medicine - Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice - Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways - Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine
Examining the State of the Science of Mammalian Embryo Model Systems
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Published: 2020-08-31
Total Pages: 155
ISBN-13: 0309676681
DOWNLOAD EBOOKBecause of the recent advances in embryo modeling techniques, and at the request of the Office of Science Policy in the Office of the Director at the National Institutes of Health, the National Academies of Sciences, Engineering, hosted a 1-day public workshop that would explore the state of the science of mammalian embryo model systems. The workshop, which took place on January 17, 2020, featured a combination of presentations, panels, and general discussions, during which panelists and participants offered a broad range of perspectives. Participants considered whether embryo model systems - especially those that use nonhuman primate cells - can be used to predict the function of systems made with human cells. Presentations provided an overview of the current state of the science of in vitro development of human trophoblast. This publication summarizes the presentation and discussion of the workshop.
Maternal Control of Development in Vertebrates
Author: Florence Louise Marlow
Publisher: Morgan & Claypool Publishers
Published: 2010
Total Pages: 221
ISBN-13: 161504051X
DOWNLOAD EBOOKEggs of all animals contain mRNAs and proteins that are supplied to or deposited in the egg as it develops during oogenesis. These maternal gene products regulate all aspects of oocyte development, and an embryo fully relies on these maternal gene products for all aspects of its early development, including fertilization, transitions between meiotic and mitotic cell cycles, and activation of its own genome. Given the diverse processes required to produce a developmentally competent egg and embryo, it is not surprising that maternal gene products are not only essential for normal embryonic development but also for fertility. This review provides an overview of fundamental aspects of oocyte and early embryonic development and the interference and genetic approaches that have provided access to maternally regulated aspects of vertebrate development. Some of the pathways and molecules highlighted in this review, in particular, Bmps, Wnts, small GTPases, cytoskeletal components, and cell cycle regulators, are well known and are essential regulators of multiple aspects of animal development, including oogenesis, early embryogenesis, organogenesis, and reproductive fitness of the adult animal. Specific examples of developmental processes under maternal control and the essential proteins will be explored in each chapter, and where known conserved aspects or divergent roles for these maternal regulators of early vertebrate development will be discussed throughout this review. Table of Contents: Introduction / Oogenesis: From Germline Stem Cells to Germline Cysts / Oocyte Polarity and the Embryonic Axes: The Balbiani Body, an Ancient Oocyte Asymmetry / Preparing Developmentally Competent Eggs / Egg Activation / Blocking Polyspermy / Cleavage/ Mitosis: Going Multicellular / Maternal-Zygotic Transition / Reprogramming: Epigenetic Modifications and Zygotic Genome Activation / Dorsal-Ventral Axis Formation before Zygotic Genome Activation in Zebrafish and Frogs / Maternal TGF-β and the Dorsal-Ventral Embryonic Axis / Maternal Control After Zygotic Genome Activation / Compensation by Stable Maternal Proteins / Maternal Contributions to Germline Establishment or Maintenance / Perspective / Acknowledgments / References
In Pursuit of Early Mammals
Author: Zofia Kielan-Jaworowska
Publisher: Indiana University Press
Published: 2013-07-12
Total Pages: 282
ISBN-13: 0253008247
DOWNLOAD EBOOK“Mesozoic mammal fossils are the focus of this fascinating book, which reviews both the fossils themselves and the history of their discovery.” —Choice In Pursuit of Early Mammals presents the history of the mammals that lived during the Mesozoic era, the time when dinosaurs ruled the Earth, and describes their origins, anatomy, systematics, paleobiology, and distribution. It also tells the story of the author, a world-renowned specialist on these animals, and the other prominent paleontologists who have studied them. Zofia Kielan-Jaworowska was the first woman to lead large-scale paleontological expeditions, including eight to the Gobi Desert in Mongolia, which brought back important collections of dinosaur, early mammal, and other fossils. She shares the difficulties and pleasures encountered in finding rare fossils and describes the changing views on early mammals made possible by these discoveries. “A thorough review of the current state of early mammalian paleontology presented through the unique historical filter of someone who was at the foremost of the field for over half a century.” —The Quarterly Review of Biology “Whether she’s talking about how mammals evolved their distinctive ear bones, or how she built a cabin out of plywood during a particularly cold field season in the Gobi, you know that a remarkable, passionate person is telling a story of science and adventure in her own words.” —Priscum “A fascinating window into the development of the field . . . The perspective of an individual at the center of these developments is captivating, informative, and has never before been published.” —Gregory P. Wilson, University of Washington
Textbook of Clinical Embryology
Author: Kevin Coward
Publisher: Cambridge University Press
Published: 2013-10-31
Total Pages: 408
ISBN-13: 110727625X
DOWNLOAD EBOOKThe success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook – inspired by the postgraduate degree program at the University of Oxford – guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology.
The Guide to Investigation of Mouse Pregnancy
Author: B. Anne Croy
Publisher: Academic Press
Published: 2013-12-09
Total Pages: 829
ISBN-13: 0123947944
DOWNLOAD EBOOKThe Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. - Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications - Describes the angiogenic tree the mother's uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes - Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation - Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success
Growth Factors in Mammalian Development
Author: I. Y. Rosenblum
Publisher: CRC Press
Published: 1989-08-31
Total Pages: 198
ISBN-13: 9780849345401
DOWNLOAD EBOOKThe purpose of this volume is to review and discuss key growth factor systems that have been implicated in embryogenesis. Emphasis is placed on the insulin family of peptides, including insulin and the structurally and functionally related insulin-like growth factors. The initial chapters provide a review of basic topics, including developmental genetics, energy metabolism and hormonal signaling mechanisms, which are important prerequisites to the central theme that follows. The book concludes with a brief review of oncogene expression in early development; this new field has contributed significantly to our understanding of how mitogenic signals activate genetic elements responsible for embryonic growth and development. This book presents information important to cell biologists, endocrinologists, biological chemists, and developmental biologists.
Early Mammalian Development
Author: Matthew H. Kaufman
Publisher: CUP Archive
Published: 1983-10-06
Total Pages: 296
ISBN-13: 9780521254496
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