Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.
This volume contains most of the papers presented at the First International Symposium on The Effect of Prolonged Drug Usage on Fetal Development held at the Beit-Berl Convention Center, Kfar Saba, Israel, on September 14 - 17, 1971. In order to obtain an overview of the effect of drugs on fetal development, it appeared desirable to gather the opinions of noted investigators regarding the goals already achieved and the future potential of prevention of fetal disorders due to drugs. More than one hundred and sixty scientists from fifteen countries participated, and over forty presented data which were collected in extensive laboratory, clinical and field studies. This small, comparatively informal, International Symposium was held in a relaxed environment and provided a suitable forum for scientists in many differing lines of research to evaluate together the recent advances in the role of drugs as teratogenic agents and methods for the rapid uncovering of the teratogenic potential of drugs to mankind.
247 entries to literature (mostly journal articles). Also some foreign-language references included. Arranged under broad topics. Entries include bibliographical information, institution, and abstract. Subject, author indexes.