Autoimmune Liver Diseases summarizes the recent high-impact research and clinical findings obtained in Japan in the study and treatment of autoimmune liver diseases. Although these disorders are relatively rare, they are recognized as an important group of refractory liver diseases, the most common of which are autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). The book therefore comprises two major sections, one dealing with AIH, the other with PBC. AIH in Japanese patients creates a unique disease population, as its clinical features are different from those of Western patients resulting from the different genetic background of the two patient populations. Also, mouse models of neonatal thymectomy-PD-1 knockout mice, clinical analyses of acute hepatitis-like manifestations, and research findings on IgG4-related autoimmune hepatitis have been reported in Japan and are included in this book. A disease-susceptibility gene specific to Japanese PBC patients has also recently been discovered. Because of the relatively homogeneous population of Japan, analyses conducted with Japanese PBC patients have yielded findings that are highly relevant to the pathogenesis of the disease. Furthermore, new pathological staging criteria, anti-gp210 antibodies and the basis they provide for improved accuracy of prognosis, treatment with bezafibrate, and the outcomes of living-donor liver transplantation are also presented here. This volume therefore serves as a useful resource not only for hepatologists, but also for researchers, clinical residents, and medical students both in Japan and in other countries.
Read along with Disney! Spoil King Triton's Coral Festival with Ursula, help Merryweather deliver Maleficent's wedding invitation, take a trip to the zoo with Cruella, and more! Each story is perfect for bedtime, story time, or any time!
A dramatic shift in the average age of the U.S. population and the increasing number of elderly Americans has introduced new and challenging healthcare dilemmas. This book addresses these issues with contributed chapters by the leading authorities in the field of behavioral medicine. It deals with health and healthcare needs of the elderly by considering basic changes that result from aging and some of the more specific problems that accompany it. Content highlights include a review of the basic tenets of genetics and molecular biology including some of the methods of looking at heritable differences in health and well-being. Quality of life concerns are addressed, including the differences between men and women, as well as other gender issues. Several chapters deal with the effects of aging on immunity. The latter part of the book emphasizes the psychosocial implications of aging on cardiovascular disease. Chronic illness among the elderly is also addressed.
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This volume explores how educators can leverage student proficiency with new literacies for learning in formal and informal educational environments. It also investigates critical literacy practices that can best respond to the proliferation of new media in society. What sorts of media education are needed to deal with the rapid influx of intellectual and communication resources and how are media professionals, educational theorists, and literacy scholars helping youth understand the possibilities inherent in such an era? Offering contributions from scholars on the forefront of media literacy scholarhip, this volume provides valuable insights into the issues of literacy and the new forms of digital communication now being utilized in schools. It is required reading for media literacy scholars and students in communication, education, and media.
Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.
Written in the form of letters to his own grandchildren, Archbishop George Carey's Canterbury Letters to the Future explores the basics of Christian faith. In accessible language and without technical jargon, Carey explores our understandings of God, Jesus and the Holy Spirit. At the same time, he weaves in details of what is occurring today in the Anglican Communion and muses about what may lie ahead for the Christian faith.