Discrimination of Chiral Compounds Using NMR Spectroscopy
Discrimination of Chiral Compounds Using NMR Spectroscopy

Author: Thomas J. Wenzel

Publisher: John Wiley & Sons

Published: 2007-04-13

Total Pages: 576

ISBN-13: 0471763527

DOWNLOAD EBOOK

A comprehensive overview of the use of NMR spectroscopy for chiral discrimination Discrimination of Chiral Compounds Using NMR Spectroscopy concisely covers the broad array of reagents that make it possible to determine the optical purity and assign the absolute configuration of many classes of compounds. It describes chiral NMR derivatizing agents, solvating agents, metal-based reagents, and liquid crystals and discusses the range and types of compounds for which they can be used for analysis. After an overview of chiral reagents and methodologies, this reference: * Includes comprehensive coverage of the chiral reagents that have been reported * Catalogs the range of compounds for which different reagents have been shown to be effective * Includes specialty categories such as liquid crystals, ionic liquids, and the formation of chiral aggregates from achiral building blocks that do not fit into the broader categories * Offers experimental strategies for using the reagents that are likely to improve the quality of the results This guide describes the various systems and their overall utility, but goes further to show the full scope of the field as a way of guiding investigations into the optimal chiral reagents for use in NMR spectroscopy. It's a practical reference for organic chemists in the pharmaceutical industry, academia, and other areas, NMR spectroscopists, and researchers involved in the isolation and structure determination of natural products.

Differentiation of Chiral Compounds Using NMR Spectroscopy
Differentiation of Chiral Compounds Using NMR Spectroscopy

Author: Thomas J. Wenzel

Publisher: John Wiley & Sons

Published: 2018-07-11

Total Pages: 606

ISBN-13: 1119323916

DOWNLOAD EBOOK

An updated guide to the most current information available for determining how to use NMR spectroscopy to differentiate chiral compounds Differentiation of Chiral Compounds Using NMR Spectroscopy offers a thoroughly revised second edition to the essential volume that puts the focus on the chiral systems that are commercially available and have been widely vetted for use in NMR spectroscopy. The text covers a broad range of reagents that make it possible to determine the enantiomeric purity and assign the absolute configuration of many classes of compounds. Comprehensive in scope, the text describes the chiral NMR differentiating agents as derivatizing agents, solvating agents, metal-based reagents and liquid crystals and gels, and explains the range and types of compounds for which they can be used for analysis. New to this edition are the most recent findings in the field as well as the development of advanced NMR measurement techniques that allow for the simplification of complex spectra resulting in more readily identified enantiodifferentiation. This important resource: Includes the most recent coverage of a large range of compounds that can be analyzed using chiral NMR reagents Explores the use of chiral NMR reagents and explains their relationship to the stereochemistry of the analyzed molecules Offers the essential information needed to help decide which method is the best NMR method to apply to a class or molecules Contains experimental strategies for using the reagents that are likely to improve the quality of the results Differentiation of Chiral Compounds Using NMR Spectroscopy is a comprehensive guide designed for investigators planning to use NMR spectroscopy to determine enantiomeric purity or assign the absolute configuration of a compound.

Physical Principles of Chirality in NMR
Physical Principles of Chirality in NMR

Author: Piotr Garbacz

Publisher: Royal Society of Chemistry

Published: 2024-09-20

Total Pages: 268

ISBN-13: 1839169591

DOWNLOAD EBOOK

How can we study one of the most elusive molecular properties, chirality, using nuclear interactions with the magnetic field that are apparently insensitive to handedness? This book answers this question from the physicochemical point of view by providing a clear, coherent, and comprehensive review of methods used in NMR studies of chirality. Presented arguments based on fundamental physical and chemical laws and in-depth descriptions of new methods utilizing purely physical interactions are mainly addressed to spectroscopists in both academia and industry. The introductory chapters provide the reader with the basics of NMR spectroscopy as a tool for the study of chiral compounds, and those more interested in the methods of chiral discrimination will benefit from the brief description of their common points and reasons why some of them may or may not work. In the following chapters, the book shows rapid progress in a newly emerging field of chirality-sensitive NMR, in particular, a search for effects that give direct information about the absolute configuration of a molecule.

Encyclopedia of Analytical Science
Encyclopedia of Analytical Science

Author:

Publisher: Elsevier

Published: 2019-04-02

Total Pages: 5142

ISBN-13: 008101984X

DOWNLOAD EBOOK

The third edition of the Encyclopedia of Analytical Science, Ten Volume Set is a definitive collection of articles covering the latest technologies in application areas such as medicine, environmental science, food science and geology. Meticulously organized, clearly written and fully interdisciplinary, the Encyclopedia of Analytical Science, Ten Volume Set provides foundational knowledge across the scope of modern analytical chemistry, linking fundamental topics with the latest methodologies. Articles will cover three broad areas: analytical techniques (e.g., mass spectrometry, liquid chromatography, atomic spectrometry); areas of application (e.g., forensic, environmental and clinical); and analytes (e.g., arsenic, nucleic acids and polycyclic aromatic hydrocarbons), providing a one-stop resource for analytical scientists. Offers readers a one-stop resource with access to information across the entire scope of modern analytical science Presents articles split into three broad areas: analytical techniques, areas of application and and analytes, creating an ideal resource for students, researchers and professionals Provides concise and accessible information that is ideal for non-specialists and readers from undergraduate levels and higher

Chiral Environmental Pollutants
Chiral Environmental Pollutants

Author: Roland Kallenborn

Publisher: Springer Nature

Published: 2021-01-29

Total Pages: 331

ISBN-13: 3030624560

DOWNLOAD EBOOK

This monograph contains a survey on the role of chirality in ecotoxicological processes. The focus is on environmental trace analysis. Areas such as toxicology, ecotoxicology, synthetic chemistry, biology, and physics are also covered in detail in order to explain the different properties of enantiomers in environmental samples. This monograph delivers a comprehensive survey for environmental trace analysts, analytical chemists, ecotoxicologists, food scientists and experienced lab workers.

Differentiation of Enantiomers II
Differentiation of Enantiomers II

Author: Volker Schurig

Publisher: Springer

Published: 2014-07-08

Total Pages: 354

ISBN-13: 3319037161

DOWNLOAD EBOOK

Chiral Derivatizing Agents, Macrocycles, Metal Complexes and Liquid Crystals for Enantiomer Differentiation in NMR Spectroscopy: Thomas J. Wenzel. Chiral NMR Solvating Additives for Differentiation of Enantiomers: Gloria Uccello-Barretta and Federica Balzano. Chiral Sensor Devices for Differentiation of Enantiomers: Kyriaki Manoli, Maria Magliulo and Luisa Torsi. Enantiopure supramolecular cages: synthesis and chiral recognition properties: Thierry Brotin, Laure Guy, Alexandre Martinez, Jean-Pierre Dutasta. Interconversion of Stereochemically Labile Enantiomers (Enantiomerization) : Oliver Trapp. Anisotropy Spectra for Enantiomeric Differentiation of Biomolecular Building Blocks: A.C. Evans, C. Meinert, J.H. Bredehöft, C. Giri, N.C. Jones, S.V. Hoffmann, U.J. Meierhenrich. Self-disproportionation of Enantiomers of Enantiomerically Enriched Compounds: Alexander E. Sorochinsky and Vadim A. Soloshonok.

Asymmetric Synthesis in Organophosphorus Chemistry
Asymmetric Synthesis in Organophosphorus Chemistry

Author: Oleg I. Kolodiazhnyi

Publisher: John Wiley & Sons

Published: 2016-09-20

Total Pages: 539

ISBN-13: 3527341536

DOWNLOAD EBOOK

Authored by one of the leading experts in the field, this is the only comprehensive overview of chiral organophosphorus compounds, from asymmetric synthesis to catalysis and pharmacological applications. As such, this unique reference covers the chemical background as well as spectroscopical analysis of phosphorus compounds, and thoroughly describes all the various synthetic strategies for these substances. Metal-, organo- and biocatalyzed reactions for the introduction of phosphorus are explained as are asymmetric oxidation and reduction methods for the preparation of all possible oxidation states of phosphorus. The text also includes industrial applications for these compounds. Of particular interest to chemists working in the field of asymmetric synthesis, as well as to the pharmaceutical industry due to the increasing number of phosphorous-containing drugs.

Chiral Recognition in Separation Methods
Chiral Recognition in Separation Methods

Author: Alain Berthod

Publisher: Springer Science & Business Media

Published: 2010-06-16

Total Pages: 349

ISBN-13: 3642124453

DOWNLOAD EBOOK

What drives a scientist to edit a book on a speci c scienti c subject such as chiral mechanisms in separation methods? Until December 2005, the journal Analytical Chemistry of the American Chemical Society (Washington, DC) had an A-page section that was dedicated to simple and clear presentations of the most recent te- niques or the state of the art in a particular eld or topic. The “A-page” section was prepared for a broad audience of chemists including industrial professionals, s- dents as well as academics looking for information outside their eld of expertise. 1 Daniel W. Armstrong, one of the editors of this journal and a twenty-year+ long friend, invited me to present my view on chiral recognition mechanisms in a simple and clear way in an “A-page” article. In 2006, the “A-page” section was maintained as the rst articles at the beginning of each rst bi-monthly issue but the pagination was no longer page distinguished from the regular research articles published by the journal. During the time between the invitation and the submission, the A-page section was integrated into the rest of the journal and the article appeared as (2006) Anal Chem (78):2093–2099.

Encyclopedia of Spectroscopy and Spectrometry
Encyclopedia of Spectroscopy and Spectrometry

Author:

Publisher: Academic Press

Published: 2016-09-22

Total Pages: 3716

ISBN-13: 0128032251

DOWNLOAD EBOOK

This third edition of the Encyclopedia of Spectroscopy and Spectrometry, Three Volume Set provides authoritative and comprehensive coverage of all aspects of spectroscopy and closely related subjects that use the same fundamental principles, including mass spectrometry, imaging techniques and applications. It includes the history, theoretical background, details of instrumentation and technology, and current applications of the key areas of spectroscopy. The new edition will include over 80 new articles across the field. These will complement those from the previous edition, which have been brought up-to-date to reflect the latest trends in the field. Coverage in the third edition includes: Atomic spectroscopy Electronic spectroscopy Fundamentals in spectroscopy High-Energy spectroscopy Magnetic resonance Mass spectrometry Spatially-resolved spectroscopic analysis Vibrational, rotational and Raman spectroscopies The new edition is aimed at professional scientists seeking to familiarize themselves with particular topics quickly and easily. This major reference work continues to be clear and accessible and focus on the fundamental principles, techniques and applications of spectroscopy and spectrometry. Incorporates more than 150 color figures, 5,000 references, and 300 articles for a thorough examination of the field Highlights new research and promotes innovation in applied areas ranging from food science and forensics to biomedicine and health Presents a one-stop resource for quick access to answers and an in-depth examination of topics in the spectroscopy and spectrometry arenas

Chiroptical Spectroscopy
Chiroptical Spectroscopy

Author: Prasad L. Polavarapu

Publisher: CRC Press

Published: 2016-10-03

Total Pages: 298

ISBN-13: 1315357194

DOWNLOAD EBOOK

This book details chiroptical spectroscopic methods: electronic circular dichroism (ECD), optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and vibrational Raman optical activity (VROA). For each technique, the text presents experimental methods for measurements and theoretical methods for analyzing the experimental data. It also includes a set of experiments that can be adopted for undergraduate teaching laboratories. Each chapter is written in an easy-to-follow format for novice readers, with necessary theoretical formalism in appendices for advanced readers.