England and the Discovery of America, 1481-1620
England and the Discovery of America, 1481-1620

Author: David B. Quinn

Publisher: Taylor & Francis

Published: 2023-08-18

Total Pages: 559

ISBN-13: 1000963802

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First published in 1974, England and the Discovery of America places the early explorations of the English in North America in the broad context of 15th and 16th century history. Marshalling evidence that cannot be pushed aside and sifting a mass of fascinating detail (including problems of cartography and the Vinland Map controversy), Professor Quinn presents circumstantial indications pointing to 1481 as the date or the discovery of America by Bristol voyagers – fishermen seeking new sources of cod, and merchant sailors with maps carrying promise of unexploited Atlantic islands. Whereas England did little to follow up her early lead, Quinn demonstrates that English initiatives from the 1580s onward, though slow, were of great importance. He brings to life the men involved in a variety of rash and heroic experiments in colonization and casts new light on their fates. He makes it clear that it was this very profusion of trial and error and trail again, as well as the conviction that settlement in temperate latitudes in North America could be effective if tenaciously enough sought, that enabled the English to strike and maintain routes in their new American world. This book will be of interest to students of English history, American history, colonial history and naval history.

Disease and Discovery
Disease and Discovery

Author: Elizabeth Fee

Publisher: Johns Hopkins University Press+ORM

Published: 2016-06-12

Total Pages: 480

ISBN-13: 1421421127

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The story of a world-renowned institution and “a broad investigation of early twentieth-century public health ideology in America” (Journal of the American Medical Association). At the end of the nineteenth century, public health was the province of part-time political appointees and volunteer groups of every variety. Public health officers were usually physicians, but they could also be sanitary engineers, lawyers, or chemists—there was little agreement about the skills and knowledge necessary for practice. In Disease and Discovery, Elizabeth Fee examines the conflicting ideas about public health’s proper subject and scope and its search for a coherent professional unity and identity. She draws on the debates and decisions surrounding the establishment of what was initially known as the Johns Hopkins School of Hygiene and Public Health, the first independent institution for public health research and education, to crystallize the fundamental questions of the field. Many of the issues of public health education in the early twentieth century are still debated today. What is the proper relationship of public health to medicine? What is the relative importance of biomedical, environmental, and sociopolitical approaches to public health? Should schools of public health emphasize research skills over practical training? Should they provide advanced training and credentials for the few or simpler educational courses for the many? Fee explores the many dimensions of these issues in the context of the founding of the Johns Hopkins school. She details the efforts to define the school’s structure and purpose, select faculty and students, and organize the curriculum, and she follows the school’s growth and adaptation to the changing social environment through the beginning of World War II. As Fee demonstrates, not simply in its formation but throughout its history, the School of Hygiene served as a crucible for the forces shaping the public health profession as a whole.

Privileged Scaffolds in Drug Discovery
Privileged Scaffolds in Drug Discovery

Author: Bin Yu

Publisher: Elsevier

Published: 2023-07-19

Total Pages: 988

ISBN-13: 044318612X

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Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years. Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable. - Provides wide coverage of privileged scaffolds in new drug discovery - Includes complex and diverse natural product scaffolds - Covers applications to peptides and peptide-based drugs