Dipeptidyl Aminopeptidases in Health and Disease
Dipeptidyl Aminopeptidases in Health and Disease

Author: Martin Hildebrandt

Publisher: Springer Science & Business Media

Published: 2006-04-11

Total Pages: 360

ISBN-13: 0306479206

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Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.

Dipeptidyl Aminopeptidases
Dipeptidyl Aminopeptidases

Author: Uwe Lendeckel

Publisher: Springer Science & Business Media

Published: 2006-12-11

Total Pages: 228

ISBN-13: 0387328246

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This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. Leading experts in the field contribute to this state-of-the-art view on these enzymes. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent.

Dipeptidyl Aminopeptidases
Dipeptidyl Aminopeptidases

Author: Uwe Lendeckel

Publisher: Springer

Published: 2008-11-01

Total Pages: 0

ISBN-13: 9780387509754

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This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. Leading experts in the field contribute to this state-of-the-art view on these enzymes. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent.

Cellular Peptidases in Immune Functions and Diseases 2
Cellular Peptidases in Immune Functions and Diseases 2

Author: Jürgen Langner

Publisher: Springer Science & Business Media

Published: 2006-04-11

Total Pages: 510

ISBN-13: 0306468263

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Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a unique feature of this multifaceted work , which combines biochemical, immunological and clinical research reports with literary reviews of the field.

Cell Surface Peptidases in Health and Disease
Cell Surface Peptidases in Health and Disease

Author: A.J. Kenny

Publisher: Taylor & Francis

Published: 1997-07

Total Pages: 408

ISBN-13:

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Cells bristle with a battery of surface enzymes, of which the peptidases form the largest and best studied group. These ectopeptidases play crucial roles in many diverse biological functions, including the termination of peptide signals in the nervous system and at peripheral sites. Some of their key physiological roles, such as those of angiotensin- and endothelin-converting enzymes in generating vasoconstrictive agents and endopeptidase-24.11 in activating natriuretic peptides, enkephalins and tachykinins, have made them prime targets for the pharmaceutical industry. Interest among immunologists and haematologists was aroused when several were shown to be identical to cell-surface markers (CD antigens) on human leukocytes. Virologists have been excited to find that some double as receptors for certain viruses.

Immunity and Inflammation in Health and Disease
Immunity and Inflammation in Health and Disease

Author: Shampa Chatterjee

Publisher: Academic Press

Published: 2017-08-31

Total Pages: 477

ISBN-13: 0128054026

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Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here. - Conceptualizes the key features in natural products which can boost immune function and immune health - Explains the intricate mechanistic aspects and balance behind immune health - Presents the pathophysiology of several diseases associated with immune system disruption

Bioactive Food Peptides in Health and Disease
Bioactive Food Peptides in Health and Disease

Author: Blanca Hernández-Ledesma

Publisher: BoD – Books on Demand

Published: 2013-01-30

Total Pages: 279

ISBN-13: 9535109642

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"Bioactive Food Peptides in Health and Disease" highlights recent developments on bioactive food peptides for the promotion of human health and the prevention/management of chronic diseases. The book provides a comprehensive revision of bioactive peptides obtained from both animal and plant food sources. Aspects related to their bioactivity, mechanism of action, and bioavailability are extensively described along the different chapters. Also, the chapters describe the impact of bioactive peptides on the physiological absorption, regulation and disease prevention. The book also covers the recent technological advances for the production of food peptides. Bioactive Food Peptides in Health and Disease provides updated and interesting information, being a good reference book for nutritional and food scientists, biochemists, industry producers, and consumers.

Ectopeptidases
Ectopeptidases

Author: Jürgen Langner

Publisher: Springer Science & Business Media

Published: 2002-02-28

Total Pages: 336

ISBN-13: 9780306467882

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The idea to compile recent results on the ectoenzymes aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 arose from the great interest given by readers world-wide to the two proceedings volumes edited by us in 1997 and 2000 (Ansorge and Langner, 1997; Langner and Ansorge, 2000). These volumes contained the presentations at two symposia held in Magdeburg (Germany) in 1996 and 1999 under the title "Cellular peptidases in immune functions and diseases", which was also the name of the Sonderforschungsbereich in Magdeburg, sponsored by the Deutsche Forschungsgemeinschaft between 1995 and 2001. Our groups in Magdeburg and Halle during the last two decades have provided results on these two enzymes in cells of the hematopoietic system that justify a review in an edited monograph like the present one (see the reviews by Kahne et at. , 1999; Lendeckel et at. ,1999; Riemann et at. , 1999). There are, however, many other groups in Europe, US and Japan which made important contributions to this field and particularly in topics improving the understanding of physiological and pathophysiological roles ofAPN/CD13 and DPIV/CD26. Therefore we decided to invite some of them to contribute reviews of their results to this book. Having worked for about 40 years in the field of proteolysis, for both of us to see the development of activities and knowledge from protein chemistry and enzymology to physiology and pathophysiology and even to therapy is very stimulating and fascinating. Of course, this development also reflects the dramatic improvement and refinement of methods.

Aminopeptidases in Biology and Disease
Aminopeptidases in Biology and Disease

Author: Nigel M. Hooper

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 347

ISBN-13: 1441988696

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Aminopeptidases in Biology and Disease provides a comprehensive review of the emerging role of aminopeptidases in a range of biological processes and disease situations. Processes as diverse as angiogenesis, antigen presentation, neuropeptide and hormone processing, pregnancy and reproduction, protein turnover, memory, inflammation, tumour growth, cancer and metastasis, blood pressure and hypertension all critically involve one or more aminopeptidases. The individual chapters have been written by experts in the field who have provided detailed accounts of the central roles played by various aminopeptidases in biology and disease.

The Diabetic Kidney
The Diabetic Kidney

Author: Pedro Cortes

Publisher: Springer Science & Business Media

Published: 2007-11-06

Total Pages: 553

ISBN-13: 1597451533

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A comprehensive and authoritative survey of recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. The authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Highlights include an entire section devoted to novel approaches to studying diabetic nephropathy with the most advanced molecular techniques, and complete descriptions of the most up-to-date views on the diagnosis and treatment of the disease. The Diabetic Kidney offers both researchers and practicing clinicians a clear understanding of the of the progress that has been made regarding the pathogenesis of diabetic nephropathy and of the therapeutic interventions needed to prevent its development or treat it.