Dilated Cardiomyopathy - ECAB
Dilated Cardiomyopathy - ECAB

Author: Ashok Seth

Publisher: Elsevier Health Sciences

Published: 2008-12-08

Total Pages: 121

ISBN-13: 8131231755

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Dilated cardiomyopathy (DCM) is traditionally referred to as idiopathic dilated cardiomyopathy (IDC), which includes genetic forms of DCM. The patients present with a wide range of symptoms like dyspnea, orthopnea, paroxysmal nocturnal dyspnea, arrhythmias or complications associated with DCM. The diagnosis is based on exclusion of the various identifiable causes of systolic left ventricular dysfunction, such as ischemic cardiomyopathy, hypertensive cardiomyopathy, alcoholic cardiomyopathy, myocarditis secondary to viral or other causes, peripartum cardiomyopathy and cardiomyopathies secondary to amyloidosis, hemochromatosis, sarcoidosis, and due to drug toxicity. The sophisticated and expensive diagnostic tests might not be feasible for a typical Indian patient. This prompts us to emphasize the need for corroborating the clinical clues with the available affordable investigative tests that also offer reasonably valid results. The medical management of congestive heart failure is vital to the management protocol of DCM. The roles of heart transplant, cardiomyoplasty and surgical devices have to be weighed from patient to patient with a clear understanding of the etiology of the disease. The recent improvement in the prognosis of DCM presents an encouraging picture to the researchers and practitioners dedicated to the development of drugs and devices to improve the life expectancy of patients of DCM. This clinical update module has been formulated to update the readers on the existing and emerging treatment strategies widely followed and recommended by practitioners of international repute. The essential features of the medical and surgical management have been discussed in detail. Moreover, a comprehensive discussion on the occurrence and management of DCM in pediatric patients has also been incorporated in this book. The book is an honest attempt to provide the medical practitioner with a wide knowledge platform about DCM and its clinical implications.

Dilated Cardiomyopathy
Dilated Cardiomyopathy

Author: Gianfranco Sinagra

Publisher: Springer

Published: 2019-05-17

Total Pages: 241

ISBN-13: 303013864X

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This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.

Idiopathic Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy

Author: Hans-Reiner Figulla

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 407

ISBN-13: 3642778917

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The latest developments in molecular biology have broadened our understanding of the pathogenesis of idiopathic dilated cardiomyopathy (IDC). In this book, written by well-known experts, a comprehensive overviewof IDC is given, including basic cellular and molecular concepts, virology, immunology, cardiac receptors and ionic channels, contractility abnormalities, microcirculation, and oxygen supply in cardiac hypertrophy. Details on basic research are supplemented by results of new clinical trials in IDC and the latest data on the epidemiology of the disease. For those who are interested in the disease, the book summarizes progress in all major fields.

Acute Coronary Syndrome - ECAB
Acute Coronary Syndrome - ECAB

Author: R R Kasliwal

Publisher: Elsevier Health Sciences

Published: 2012-07-26

Total Pages: 176

ISBN-13: 8131231771

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Acute coronary syndrome (ACS) is the term for the clinical signs and symptoms of myocardial ischemia: unstable angina, non–ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI). Unstable angina and NSTEMI normally result from a partially or intermittently occluded coronary artery, whereas STEMI results from a fully occluded coronary artery. The patients present with a wide arena of signs and symptoms like chest pain, nausea/vomiting, exertional pain, palpitation, shortness of breath, fatigue, etc. Angina, or chest pain, continues to be recognized as the classic symptom of ACS. In unstable angina, chest pain normally occurs either at rest or with exertion and results in limited activity. Chest pain associated with NSTEMI is usually longer in duration and more severe than chest pain associated with unstable angina. The diagnosis of ACS is based on triad of clinical presentation, electrocardiography and cardiac biomarkers. Electrocardiography is the most important initial diagnostic procedure when doctors suspect an acute coronary syndrome. Findings on a 12-lead ECG help the practitioner to differentiate between myocardial ischemia, injury, and infarction, locate the affected area and assess related conduction abnormalities. But at the same front, the definition of unstable angina, NSTEMI and STEMI is based on the levels of cardiac biomarkers too. Acute coronary syndromes are medical emergencies that need prompt action. Half of deaths due to a heart attack occur in the first 3–4 hours after symptoms begin. The sooner treatment begins, the better the chances of survival. Anyone having symptoms that might indicate an acute coronary syndrome should obtain prompt medical attention. Management of ACS involves a spectrum of interventions. It encompasses cardiac monitoring, thrombolysis, antiplatelet therapy, anticoagulant therapy, reperfusion therapy and invasive investigation and revascularization therapy. Reperfusion therapy (percutaneous coronary intervention) mainly holds for the ST-elevation myocardial infarction. Prognosis of the ACS patients depends on the post-myocardial risk stratification. The main highlights of risk stratification are risk stratification scores, assessment of cardiac function and stress testing, and management.

High-Risk Labor and Delivery - ECAB
High-Risk Labor and Delivery - ECAB

Author: Shirish N Daftary

Publisher: Elsevier Health Sciences

Published: 2012-06-19

Total Pages: 272

ISBN-13: 813123231X

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The high-risk pregnant patient can present to the labor and delivery setup with significant complications that can result in morbidity and mortality. The goal of the obstetricians is always to have a safe outcome for both the mother and the baby, irrespective of the severity of the illness. Therefore, a thorough understanding of the underlying problems and expert management by the obstetrician are extremely important. Further, these parturient can be critically ill, requiring intensive care management. So, good communication among the various teams and the latest information on the management of such patients are critical in order to provide the highest possible level of care. The information in this text will hopefully give the reader the best and most up-to-date knowledge with regard to management of problems and challenges in dealing with a high-risk parturient. This book brings together an outstanding group of authors from the discipline of Obstetrics and Gynaecology in an attempt to present a comprehensive and current summary of high-risk labor and delivery and will be useful to both the practitioner in academic medicine and in private practice.

Medical Disorders in Pregnancy - ECAB
Medical Disorders in Pregnancy - ECAB

Author: Hema Divakar

Publisher: Elsevier Health Sciences

Published: 2009-11-15

Total Pages: 194

ISBN-13: 8131232271

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The management of medical disorders in pregnancy has undergone significant changes in the recent years. The pattern of disease has changed with improvements in socio-economic conditions. For example, the incidence of antenatal anemia has decreased progressively in the past few decades, and pulmonary tuberculosis (which used to be prevalent) is now seen only rarely. Chronic rheumatic heart disease has also become less common. On the other hand, gestational diabetes has become more common. This may be due partly to the setting up of screening services for gestational diabetes in many hospitals. The four most common medical disorders complicating pregnancy are anemia, diabetes mellitus, cardiac disease, and thyroid disorders. In addition, because of the improvements in the medical, obstetric, and anesthetic management of pregnancy, many women with medical disorders can go through a pregnancy without major problems. There has also been a progressive decrease in the perinatal mortality associated with some medical disorders, such as diabetes. It is important for all healthcare professionals involved in the management of pregnant women with medical disorders to be conversant with the latest developments in order to provide the best care to these women. The chapters in this issue are certainly helpful in this respect. The eminent authors for the various chapters have discussed the various options available describing in detail their experiences regarding the various aspects of the condition.

Left to Right Shunts - ECAB
Left to Right Shunts - ECAB

Author: Nagaraj Desai

Publisher: Elsevier Health Sciences

Published: 2012-07-05

Total Pages: 97

ISBN-13: 8131231747

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Patients born with cardiac defects need to be identified early and the severity of symptoms also needs to be identified. In children with larger defects or with more symptoms, early institution of treatment is warranted, since in absence of treatment, the disease progresses to pulmonary hypertension and a simple pathology gets complicated. Presence of congestive cardiac failure in infancy or of pulmonary artery hypertension is indication for early surgical treatment (prior to 6 months of age). Untreated ASD may at times allow the child to grow and reach adulthood, but can cause complications in adulthood also. These issues related to understanding of natural history of the shunts and its implications in management decisions need to be addressed in clear terms. Also the role and timing of surgical therapy need to be emphasized. This book is designed to address such questions with supportive clinical scenarios. Thus, it provides an excellent opportunity to widen one’s perspective in this area.

Pulmonary Hypertension - ECAB
Pulmonary Hypertension - ECAB

Author: Sheila Glennis Haworth

Publisher: Elsevier Health Sciences

Published: 2008-12-26

Total Pages: 182

ISBN-13: 8131231763

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Pulmonary hypertension is defined as a mean pulmonary artery pressure (mPAP) ≥25 mmHg, with Pulmonary Capillary Wedge Pressure ≤ 15 mmHg, measured by cardiac catheterization. The etiology of PH has a varied spectrum extending right from Drugs, toxins and portal hypertension to HIV, Collagen Vascular Diseases and Persistent Pulmonary Hypertension of Newborn, etc. The estimation of disease prevalence has been nearly impossible owing to the geographic distribution and economic diversity, along with significant regional variations in human development and healthcare infrastructure. A large number of patients with PH never reach the health centers capable of diagnosing the disease condition correctly. Advance pulmonary vascular disease as a result of uncorrected CHD is a major health challenge in the developing world. PH exists as a major component of many forms of cardiac and pulmonary disease. While breathlessness is the most common feature of PH, patients often also present with chest pain, syncope, fatigue, weakness and abdominal distension. The precordial signs include a right ventricular lift, accentuated pulmonary component of S2, a pansystolic murmur of Tricuspid regurgitation, a diastolic murmur of pulmonary regurgitation and a right ventricular S3. The standard diagnostic workup in developed countries includes a series of investigations to rule out the secondary causes. Additional tests are required to estimate the disease severity and plan the appropriate treatment. These include the cardiac catheterization, selective pulmonary angiography by direct injection of pulmonary arteries, high resolution CT scan, cardiac magnetic resonance, ABGs, nocturnal O2 saturation, etc. While most of the basic management is feasible in the Indian conditions, most of the newly introduced drugs are either not available or are available at costs that far exceed the paying capacity of an average citizen of a developing economy. An underdeveloped health insurance system adds further to the financial burden of the treatment. Measures like formulation of guidelines for diagnosis and treatment of PAH, educating clinicians and scientists and making medications affordable to poor patients might ensue a breakthrough in the overall management of pulmonary hypertension.