Bones and Cartilage
Bones and Cartilage

Author: Brian K. Hall

Publisher: Academic Press

Published: 2014-12-23

Total Pages: 911

ISBN-13: 0124166857

DOWNLOAD EBOOK

Bones and Cartilage provides the most in-depth review and synthesis assembled on the topic, across all vertebrates. It examines the function, development and evolution of bone and cartilage as tissues, organs and skeletal systems. It describes how bone and cartilage develop in embryos and are maintained in adults, how bone is repaired when we break a leg, or regenerates when a newt grows a new limb, or a lizard a new tail. The second edition of Bones and Cartilage includes the most recent knowledge of molecular, cellular, developmental and evolutionary processes, which are integrated to outline a unified discipline of developmental and evolutionary skeletal biology. Additionally, coverage includes how the molecular and cellular aspects of bones and cartilage differ in different skeletal systems and across species, along with the latest studies and hypotheses of relationships between skeletal cells and the most recent information on coupling between osteocytes and osteoclasts All chapters have been revised and updated to include the latest research. - Offers complete coverage of every aspect of bone and cartilage, with updated references and extensive illustrations - Integrates development and evolution of the skeleton, as well a synthesis of differentiation, growth and patterning - Treats all levels from molecular to clinical, embryos to evolution, and covers all vertebrates as well as invertebrate cartilages - Includes new chapters on evolutionary skeletal biology that highlight normal variation and variability, and variation outside the norm (neomorphs, atavisms) - Updates hypotheses on the origination of cartilage using new phylogenetic, cellular and genetic data - Covers stem cells in embryos and adults, including mesenchymal stem cells and their use in genetic engineering of cartilage, and the concept of the stem cell niche

Developmental Biology and Musculoskeletal Tissue Engineering
Developmental Biology and Musculoskeletal Tissue Engineering

Author: Martin J. Stoddart

Publisher: Academic Press

Published: 2018-04-24

Total Pages: 272

ISBN-13: 0128115386

DOWNLOAD EBOOK

Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells. - Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes - Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues - Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering - Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering - Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair

Developmental and Cellular Skeletal Biology
Developmental and Cellular Skeletal Biology

Author: Brian K. Hall

Publisher: Academic Press

Published: 2013-10-22

Total Pages: 315

ISBN-13: 1483267210

DOWNLOAD EBOOK

Developmental and Cellular Skeletal Biology reviews the development, growth, and cell biology of the skeleton. The monograph provides a comprehensive overview of the aspects of skeletal biology, focusing mainly on the cellular level. It covers topics on the types of skeletal tissues, its evolution, and origin; location of the skeleton within the embryo; initiation of centers of skeletogenesis; and the initiation of skeletal growth. The book will be of great use to physiologists, cell biologists, hematologists, pathologists, orthopedic surgeons, and others whose professions are concerned with the study of the skeletal system.

The Skeletal System
The Skeletal System

Author: Olivier Pourquié

Publisher:

Published: 2009

Total Pages: 0

ISBN-13: 9780879698256

DOWNLOAD EBOOK

With additional chapters covering the evolution of the vertebrate skeleton and the genetics of human skeletal disease, The Skeletal System is a vital reference for developmental biologists and clinicians wishing to learn how the skeleton is built and works.

Genetics of Bone Biology and Skeletal Disease
Genetics of Bone Biology and Skeletal Disease

Author: Rajesh V. Thakker

Publisher: Academic Press

Published: 2017-10-31

Total Pages: 880

ISBN-13: 0128041986

DOWNLOAD EBOOK

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. - Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments - Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders - Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

Principles of Bone Biology
Principles of Bone Biology

Author: John P. Bilezikian

Publisher: Academic Press

Published: 2008-09-29

Total Pages: 2074

ISBN-13: 0080568750

DOWNLOAD EBOOK

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. - Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field - The essential resource for anyone involved in the study of bones and bone diseases - Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics - Readers can easily search and locate information quickly as it will be online with this new edition

Designing Foods
Designing Foods

Author: National Research Council

Publisher: National Academies Press

Published: 1988-02-01

Total Pages: 384

ISBN-13: 0309037956

DOWNLOAD EBOOK

This lively book examines recent trends in animal product consumption and diet; reviews industry efforts, policies, and programs aimed at improving the nutritional attributes of animal products; and offers suggestions for further research. In addition, the volume reviews dietary and health recommendations from major health organizations and notes specific target levels for nutrients.

The Growth Plate
The Growth Plate

Author: Irving M. Shapiro

Publisher: IOS Press

Published: 2002

Total Pages: 312

ISBN-13: 9781586032401

DOWNLOAD EBOOK

Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.

Bone and Development
Bone and Development

Author: Felix Bronner

Publisher: Springer Science & Business Media

Published: 2010-03-10

Total Pages: 321

ISBN-13: 1848828225

DOWNLOAD EBOOK

This, the sixth volume in a series of reviews centered on a single major topic in osteopathy, examines pediatric bone development. It covers problematic aspects from basic skeletal growth to tooth mineralization, and synthesizes theory and practice.