Eliminating the Public Health Problem of Hepatitis B and C in the United States
Eliminating the Public Health Problem of Hepatitis B and C in the United States

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2016-06-01

Total Pages: 187

ISBN-13: 0309438020

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Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the first of two, examines the feasibility of hepatitis B and C elimination in the United States and identifies critical success factors. The phase two report will outline a strategy for meeting the elimination goals discussed in this report.

Guidelines on Hepatitis B and C Testing
Guidelines on Hepatitis B and C Testing

Author: World Health Organization

Publisher: World Health Organization

Published: 2017

Total Pages: 0

ISBN-13: 9789241549981

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Testing and diagnosis of hepatitis B (HBV) and C (HCV) infection is the gateway for access to both prevention and treatment services, and is a crucial component of an effective response to the hepatitis epidemic. Early identification of persons with chronic HBV or HCV infection enables them to receive the necessary care and treatment to prevent or delay progression of liver disease. Testing also provides an opportunity to link people to interventions to reduce transmission, through counselling on risk behaviors and provision of prevention commodities (such as sterile needles and syringes) and hepatitis B vaccination. These are the first WHO guidelines on testing for chronic HBV and HCV infection and complement published guidance by WHO on the prevention, care and treatment of chronic hepatitis C and hepatitis B infection. These guidelines outline the public health approach to strengthening and expanding current testing practices for HBV and HCV, and are intended for use across age groups and populations.

HCV: The Journey from Discovery to a Cure
HCV: The Journey from Discovery to a Cure

Author: Michael J. Sofia

Publisher: Springer Nature

Published: 2019-11-23

Total Pages: 457

ISBN-13: 3030282074

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Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide. It is also one of the major causes of liver cancer and liver transplants. The elucidation of the HCV genome, and the development of a whole cell system to study the virus spurred the search for novel direct acting antiviral drugs to cure this disease. This global effort culminated in the development of direct acting antiviral drugs that led to cure rates approaching 100% in all patient populations after only 8-12 weeks of therapy. These efforts resulted in one of the greatest achievements in public health and provides the potential for eliminating HCV as a major disease worldwide. This volume is aimed at a broad audience of academic and industrial scientists interested in the discovery and development of drugs to treat viral diseases and those interested in reading about one of the most unique accomplishments in biomedical research. The volume will provide a one of a kind reference work that highlights the many efforts, from the discovery of the HCV virus, to the invention of breakthrough medicines and their use in the real world to cure patients. It is the companion book to the volume "HCV: The Journey from Discovery to a Cure - Volume II".

Hepatitis C: Care and Treatment
Hepatitis C: Care and Treatment

Author: Angelos Hatzakis

Publisher: Springer Nature

Published: 2021-05-10

Total Pages: 219

ISBN-13: 3030677621

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This volume provides the reader with a detailed overview of the current state-of-the art approach of Hepatitis C management. It reviews the course of action in handling of chronic Hepatitis C patients with various HCV genotypes and treats special cases such as acute hepatitis, transplant and renal patients as well as people who inject drugs. The two volume work on Hepatitis C introduces to the topic by reviewing virology, diagnosis, epidemiology, prevention, management and elimination of HCV. The book provides a valuable source at full length for researchers and clinicians working on Hepatitis C.

Chronic Hepatitis C Virus
Chronic Hepatitis C Virus

Author: Mitchell L. Shiffman

Publisher: Springer Science & Business Media

Published: 2011-11-17

Total Pages: 333

ISBN-13: 1461411920

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Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.

Triumph Over Hepatitis C
Triumph Over Hepatitis C

Author: Lloyd Wright

Publisher: Unistar Books

Published: 2002

Total Pages: 306

ISBN-13:

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Eight Years Ago Lloyd Wright was diagnosed with Chronic Hepatitis C. If experience is the best teacher, then Lloyd Wright is truly an expert. As a Hepatitis C researcher and author. Lloyd has developed more substantial credentials than many doctors or scientists currently treating and researching the virus. Lloyd had Hepatitis C and beat it. Standing up against a legion of medical doctors who insist there is no cure, he researched this disease and he proved them wrong. Now he wants to share this cure with other Hepatitis C sufferers. Book jacket.

Curing Hepatitis C
Curing Hepatitis C

Author: Gregory T. Everson

Publisher: Hatherleigh Press

Published: 2012-08-21

Total Pages: 185

ISBN-13: 1578264405

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Hepatitis C Doesn't Have to Be a Lifelong Illness Curing Hepatitis C provides the latest information to guide you through the diagnosis and treatment of hepatitis C. If you or a loved one has been diagnosed with hepatitis C, this book provides an indispensable and comprehensive overview of everything you need to know to take the right steps toward a cure. For the nearly 160 million people worldwide and 4 million Americans diagnosed with hepatitis C, there is now hope. Although hepatitis C was once considered incurable, medical and technological innovations have made a cure possible. A new frontier of treatment options has improved upon previous methods by curbing side-effects more effectively and working to eradicate hepatitis C entirely. Curing Hepatitis C also includes: * Easy-to-understand explanations of the nature of hepatitis C * The revealing truth of misconceptions about hepatitis C * Tips to prevent, diagnose, cope with, and ultimately cure this disease * An overview of types of tests and how to understand your results * Breakthrough treatments and medications for hepatitis C, such as triple therapy * The next generation of treatments including interferon-free regimens, QUAD therapy, host-acting antivirals, and more * Personal anecdotes from those affected by hepatitis C

HCV: The Journey from Discovery to a Cure
HCV: The Journey from Discovery to a Cure

Author: Michael J. Sofia

Publisher: Springer Nature

Published: 2020-02-07

Total Pages: 493

ISBN-13: 303028400X

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​Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide. It is also one of the major causes of liver cancer and liver transplants. The elucidation of the HCV genome, and the development of a whole cell system to study the virus spurred the search for novel direct acting antiviral drugs to cure this disease. This global effort culminated in the development of direct acting antiviral drugs that led to cure rates approaching 100% in all patient populations after only 8-12 weeks of therapy. These efforts resulted in one of the greatest achievements in public health and provides the potential for eliminating HCV as a major disease worldwide. This volume is aimed at a broad audience of academic and industrial scientists interested in the discovery and development of drugs to treat viral diseases and those interested in reading about one of the most unique accomplishments in biomedical research. The volume will provide a one of a kind reference work that highlights the many efforts, from the discovery of the HCV virus, to the invention of breakthrough medicines and their use in the real world to cure patients. It is the companion book to the volume "HCV: The Journey from Discovery to a Cure - Volume I".

Hepatitis C Treatment One Step at a Time
Hepatitis C Treatment One Step at a Time

Author: Lucinda Porter RN

Publisher: Demos Medical Publishing

Published: 2013-09-19

Total Pages: 248

ISBN-13: 1936303523

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Hepatitis C Treatment One Step at a Time provides the practical advice and daily inspiration you need to help you successfully complete hepatitis C (HCV) treatment. Deciding to undergo HCV antiviral therapy is one of the bravest and most important steps toward health you'll ever make. As a nurse in the HCV field and a patient who underwent three courses of HCV therapy, Lucinda K. Porter understands how physically and emotionally challenging this experience can be. In Hepatitis C Treatment One Step at a Time, she provides entries for each day of treatment, offering you a daily dose of relief, encouragement, and tips to help you stay on track. From dealing with fatigue and nausea to nosy co-workers and lab results, Porter shows you how to: Prepare mentally, physically, and financially Manage side effects Set up a support system Keep your spirits up Celebrate your strength and acknowledge your milestones Find additional help and up-to-date information with an extensive resources section