Angiogenesis Assays
Angiogenesis Assays

Author: Carolyn A. Staton

Publisher: John Wiley & Sons

Published: 2007-01-11

Total Pages: 410

ISBN-13: 047002934X

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Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

Methods of Seawater Analysis
Methods of Seawater Analysis

Author: Klaus Grasshoff

Publisher: John Wiley & Sons

Published: 2009-07-30

Total Pages: 632

ISBN-13: 3527613994

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Since the book first appeared in 1976, Methods of Seawater Analysis has found widespread acceptance as a reliable and detailed source of information. Its second extended and revised edition published in 1983 reflected the rapid pace of instrumental and methodological evolution in the preceding years. The development has lost nothing of its momentum, and many methods and procedures still suffering their teething troubles then have now matured into dependable tools for the analyst. This is especially evident for trace and ultra-trace analyses of organic and inorganic seawater constituents which have diversified considerably and now require more space for their description than before. Methods to determine volatile halocarbons, dimethyl sulphide, photosynthetic pigments and natural radioactive tracers have been added as well as applications of X-ray fluorescence spectroscopy and various electrochemical methods for trace metal analysis. Another method not previously described deals with the determination of the partial pressure of carbon dioxide as part of standardised procedures to describe the marine CO2 system.

College Life in the Old South
College Life in the Old South

Author: E. Merton Coulter

Publisher: University of Georgia Press

Published: 2009-01-01

Total Pages: 342

ISBN-13: 0820331996

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Relates the early history of the University of Georgia from its founding in 1785 through the Reconstruction era. In this history of America's first chartered state university, the author recounts, among other things, how Athens was chosen as the university's location; how the state tried to close the university and refused to give it a fixed allowance until long after the Civil War; the early rules and how students invariably broke them; the days when the Phi Kappa and Demosthenian literary societies ruled the campus; and the vast commencement crowds that overwhelmed Athens to feast on oratory and watermelons.

Sustainable Horticultural Systems
Sustainable Horticultural Systems

Author: Dilip Nandwani

Publisher: Springer

Published: 2014-10-14

Total Pages: 400

ISBN-13: 3319069047

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Sustainable horticulture is gaining increasing attention in the field of agriculture as demand for the food production rises to the world community. Sustainable horticultural systems are based on ecological principles to farm, optimizes pest and disease management approaches through environmentally friendly and renewable strategies in production agriculture. It is a discipline that addresses current issues such as food security, water pollution, soil health, pest control, and biodiversity depletion. Novel, environmentally-friendly solutions are proposed based on integrated knowledge from sciences as diverse as agronomy, soil science, entomology, ecology, chemistry and food sciences. Sustainable horticulture interprets methods and processes in the farming system to the global level. For that, horticulturists use the system approach that involves studying components and interactions of a whole system to address scientific, economic and social issues. In that respect, sustainable horticulture is not a classical, narrow science. Instead of solving problems using the classical painkiller approach that treats only negative impacts, sustainable horticulture treats problem sources.

Experimental Approaches of NMR Spectroscopy
Experimental Approaches of NMR Spectroscopy

Author: The Nuclear Magnetic Resonance Society of Japan

Publisher: Springer

Published: 2017-11-23

Total Pages: 634

ISBN-13: 9811059667

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This book describes the advanced developments in methodology and applications of NMR spectroscopy to life science and materials science. Experts who are leaders in the development of new methods and applications of life and material sciences have contributed an exciting range of topics that cover recent advances in structural determination of biological and material molecules, dynamic aspects of biological and material molecules, and development of novel NMR techniques, including resolution and sensitivity enhancement. First, this book particularly emphasizes the experimental details for new researchers to use NMR spectroscopy and pick up the potentials of NMR spectroscopy. Second, the book is designed for those who are involved in either developing the technique or expanding the NMR application fields by applying them to specific samples. Third, the Nuclear Magnetic Resonance Society of Japan has organized this book not only for NMR members of Japan but also for readers worldwide who are interested in using NMR spectroscopy extensively.

Animal Manure
Animal Manure

Author: Heidi M. Waldrip

Publisher: John Wiley & Sons

Published: 2020-05-05

Total Pages: 448

ISBN-13: 0891183701

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The majority of meat, milk, and eggs consumed in the United States are produced in concentrated animal feeding operations (CAFO). With concentrated animal operations, in turn comes concentrated manure accumulation, which can pose a threat of contamination of air, soil, and water if improperly managed. Animal Manure: Production, Characteristics, Environmental Concerns, and Management navigates these important environmental concerns while detailing opportunities for environmentally and economically beneficial utilization.

Cancer Chemotherapy and Biotherapy
Cancer Chemotherapy and Biotherapy

Author: Bruce A. Chabner

Publisher: Lippincott Williams & Wilkins

Published: 2011-12-07

Total Pages: 836

ISBN-13: 1451148208

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Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.