Unlike other textbooks on this subject, which are more focused on end of life, the 4th edition of Principles and Practice of Palliative Care and Supportive Oncology focuses on supportive oncology. In fact, the goal of this textbook is to provide a source of both help and inspiration to all those who care for patients with cancer. Written in a more reader-friendly format, this textbook not only offers authoritative and up-to-date reviews of research and clinical care best practices, but also practical clinical applications to help readers put everything they learn to use.
This first edition of Principles and Practice of Pediatric Endocrinology brings together 30 authors from 4 countries to present an update on the molecular basis of endocrine disorders in infants, children and adolescents as well as the diagnosis and treatment of these conditions. It is intended for the use of practitioners, fellows and clinical and “bench-top” researchers in this field, and presents advances in each of 12 areas of the normal and abnormal endocrine state. The work is a tribute to all those past and present whose research and clinical efforts resulted in the rapidly increasing accumulation of knowledge in this field, and includes comprehensive, practical clinical presentations in the form of an Atlas following each chapter after the comprehensive introductory chapter by Drs. Root and Rogol. This publication owes a great debt to Lawson Wilkins, a Baltimore pediatrician who first formally established the separate discipline of pediatric endocrinology, to Edwards Park, Fuller Albright, Bob Blizzard, Claude Migeon, Harold and Helen Harrison, James Tanner and to so many others: giants upon whose shoulders pediatric endocrinologists stand. Disorders of growth and pubertal development are the cornerstones of pediatrics as they are present in many children with chronic illness as well as in children whose growth and pubertal development are influenced by genetics and family history. These may have identifiable causes in pituitary, thyroid, adrenal or gonadal function, and examples are well represented in this book. Obesity and diabetes (types I and 2) are, likewise, diseases of childhood that are becoming increasingly and significantly prevalent and are included in this work. Disorders of calcium/phosphorus (especially the often forgotten but not gone Vitamin D deficiency rickets) and water metabolism are presented, and errors of sexual differentiation (an increasingly controversial issue) are highlighted. It is the hope of the editors that this work will assist the practitioner and researcher in this field in his or her efforts to diagnose, treat and establish the etiology of endocrine disorders in infants, children and adolescents.
In the past two decades, there have been astonishing advances in our understanding of the neurobiological basis and nature of drug addiction. We now know the initial molecular sites of action, at identified receptors, of virtually all of the major drugs of abuse including cocaine, heroin, and amphetamine, as well as legal drugs such as nicotine and alcohol. We also understand the main components of a 'reward system' and its connections to major brain regions involved in motivation and emotion, such as the amygdala, hippocampus, and prefrontal cortex. The Neurobiology of Addiction describes the latest advances in our understanding of addiction. It brings together world class researchers to debate the nature and extent of addiction, as well as its causes, consequences, and treatment. The focus of the book is on the brain processes underlying addiction, in terms of neural systems, neurochemical basis, and molecular changes. Several types of addiction are discussed ranging from illicit drugs - cocaine, amphetamine, and heroin to legal drugs - alcohol and nicotine. In addition, it explores increasingly common behavioural addictions such as gambling and obesity. Included are chapters on vulnerability to addiction, genetic factors, opponent motivational processes, animal models, relapse, cognitive deficits associated with drug abuse, new pharmacological treatments, and current controversies concerning different neuropsychological theories of addiction. Throughout, it reports on cutting edge research using brain imaging, and state of the art molecular methodology. The book will make fascinating reading for students and teachers in the field of neuroscience, pharmacology and psychology, as well as experts in the field.
Quality of life is an important outcome when treating a cancer patient. Research is vast on the role of quality of life on patients' general wellbeing, responsiveness to treatment, and even mortality. On the other hand, there are several methodological considerations when planning to measure and assess quality of life in cancer patients. This handbook – with authorship that is diverse in terms of perspectives, countries, and fields – aims to fill a gap in the available literature and responds to a number of questions in its 26 chapters: What is quality of life and health-related quality of life and why are they important? How is quality of life assessed? What are the theoretical and methodological considerations when using quality of life outcomes in cancer research? How is quality of life useful in routine clinical care? How is quality of life impacting different cancer populations in terms of site of the cancer, age, gender, and context? Handbook of Quality of Life in Cancer is a learning and consulting tool that can be used by a diverse audience. It is an essential resource for researchers who wish to use quality of life assessment tools in clinical trials or other types of studies; clinicians who want to develop their understanding of how they can utilize quality of life and how it is important for the patients they care for; and commissioners who wish to see why quality of life may impact population health and health system costs. Students in diverse fields of study (medicine, nursing, psychology, social work, medical sociology, population health, epidemiology, and medical statistics, among others) also would benefit from using the handbook for their studies and for their continuing professional development.
Neuropeptides and Stress presents a comprehensive survey by leading pioneers in the field of the knowledge and concepts implicating neuropeptides in the regulations of responses to stress. Topics covered include: recent advances on the regulation and modulation of the behavioral, endocrine, autonomic, gastrointestinal, immune and analgesic responses to stress by neuropeptides. Neuroanatomical and biological data are considered. Special emphasis is given to corticotropin-releasing factor (CRF) and opioid peptides.
Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields. Comprehensive and updated coverage of a rapidly growing field of research Unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics Covers an unusual breadth of topics and subject fields, ranging from molecules to ecophysiology, and from basic science to clinical research Ideal resource for interdisciplinary learning and understanding in the fields of hormones and behavior
Fitness education is often overlooked for various reasons: no equipment, no weight room, large class size, or lack of professional development. Designing and Teaching Fitness Education Courses provides real solutions for all these issues. This book offers secondary-level physical educators innovative ideas, practical answers, and guidance in implementing fitness education programming that will meet the needs of all students. Designing and Teaching Fitness Education Courses is packed with highly useful tools and resources: 211 instructional photos showing exercises and stretches that require no equipment and are easily adapted for varying abilities 18 pacing guides that form a week-by-week blueprint for implementing a semester-long fitness education course A robust online resource with all 18 pacing guides, as well as a blank template for developing your own; 139 video demonstrations of all the book’s exercises and stretches; PowerPoint presentations to show in PE classes, including video demonstrations of the book’s exercises and stretches; and teacher aids and student handouts, including assignments, assessments, posters, and a 12-week personal fitness plan Teachers can use the pacing guides to develop a semester-long fitness education course that can be implemented in either a traditional or block schedule. These guides offer objectives, class discussion topics, activities, assessments, and teaching strategies for each week of an 18-week semester. All topics in the guides are aligned with SHAPE America’s National Standards and Grade-Level Outcomes for K–12 Physical Education. The authors guide teachers in addressing the following priorities within a fitness education course: social and emotional learning; behavior modification principles and adherence to fitness activities; social cognitive theory; classroom management; student safety; equity, diversity, and inclusion; and social justice. Designing and Teaching Fitness Education Courses also includes a detailed chapter on nutrition education written by internationally recognized sport nutritionist Lisa Dorfman, who provides teachers a wealth of information to integrate into fitness courses. Teachers will learn how to integrate a quality fitness education curriculum into any setting (rural, urban, or suburban) and any learning model (remote, hybrid, or in-person learning). Designing and Teaching Fitness Education Courses is organized into three sections: Part I presents both theoretical and practical knowledge of fitness education; its importance in a standards-based curriculum; pedagogical and content knowledge considerations; nutrition, wellness, and consumer issues; and the general components of fitness education. Part II focuses on various components of fitness education: flexibility, strength, and cardiorespiratory fitness. This part includes stretching and muscular strength and endurance workouts, illustrated with photos in the book and videos in the online resource. Part III guides readers in enabling students to participate in community fitness and activity events to support the development of lifelong fitness habits. Through Designing and Teaching Fitness Education Courses, teachers will be able to provide appropriate fitness activities that will lead to the elevated health and wellness of students and a greater appreciation for participating in lifelong activities. Note: A code for accessing HKPropel is included with all new print books.
Endocrinology is a field in which enormous advances have been made in the last decade; the rate of discovery of new hormones, hormone-like molecules, receptors, and mechanisms of action is continually advancing. The development of techniques in immunology and molecular biology has led to the possibility of describing in detail the gene structure of many of the compounds involved in hormonal systems. Remarkable homology has been shown between oncogene products and various components of the endocrine network, leading to the asser tion that deregulation of hormonal function is involved in the generation and/or development of cancer. We now know that the central nervous system is both a target and a production site of many hormonal products, and that hormones, neurotransmitters, growth factors and immunopeptides all act through similar mechanisms. The only second messenger known ten years ago was cAMP; today calcium, derivatives of membrane phospholipids, and protein kinases are also known to be mediators of hormone action. The very concept of hormonal systems has been expanded to include not only endocrine secretions but also para- and autohormones and their mechanisms of action; an understanding of their functions will be central to the immediate future of medicine. The discovery of hormonal molecules and endocrine interactions and the subsequent understanding of hormone related pathophysiology has led to the development of new strategies in medical treatment such as fertility control and the management of diabetes.
This powerful volume represents the broadest engagement with disability issues in South Africa yet. Themes include theoretical approaches to, and representations of, disability; governmental and civil society responses to disability issues; aspects of education as these pertain to the oppression/liberation of disabled people; social security for disabled people; the complex politics permeating service provision relationships; and a consideration of disability in relation to human spaces - physical, economic and philosophical. Firmly located within the social model of disability, this collection resonates powerfully with contemporary thinking and research in the disability field and sets a new benchmark for cutting-edge debates in a transforming South Africa.
