Computer Simulation Study of Collective Phenomena in Dense Suspensions of Red Blood Cells under Shear
Computer Simulation Study of Collective Phenomena in Dense Suspensions of Red Blood Cells under Shear

Author: Timm Krüger

Publisher: Springer Science & Business Media

Published: 2012-10-02

Total Pages: 169

ISBN-13: 3834823767

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The rheology of dense red blood cell suspensions is investigated via computer simulations based on the lattice Boltzmann, the immersed boundary, and the finite element methods. The red blood cells are treated as extended and deformable particles immersed in the ambient fluid. In the first part of the work, the numerical model and strategies for stress evaluation are discussed. In the second part, the behavior of the suspensions in simple shear flow is studied for different volume fractions, particle deformabilities, and shear rates. Shear thinning behavior is recovered. The existence of a shear-induced transition from a tumbling to a tank-treading motion is demonstrated. The transition can be parameterized by a single quantity, namely the effective capillary number. It is the ratio of the suspension stress and the characteristic particle membrane stress. At the transition point, a strong increase in the orientational order of the red blood cells and a significant decrease of the particle diffusivity are observed. However, the average cell deformation shows no signature of the transition.

Computational Blood Cell Mechanics
Computational Blood Cell Mechanics

Author: Ivan Cimrak

Publisher: CRC Press

Published: 2018-09-06

Total Pages: 191

ISBN-13: 135137866X

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Simulating blood cells for biomedical applications is a challenging goal. Whether you want to investigate blood flow behavior on the cell scale, or use a blood cell model for fast computational prototyping in microfluidics, Computational Blood Cell Mechanics will help you get started, and show you the path forward. The text presents a step-by-step approach to cell model building that can be adopted when developing and validating models for biomedical applications, such as filtering and sorting cells, or examining flow and deformations of individual cells under various conditions. It starts with basic building-blocks that, together, model the red blood cell membrane according to its physical properties, before moving on to discuss several issues that may pose problems along the way, and finally leads to suggestions on how to set up computational experiments. More details available at www.compbloodcell.eu

High Performance Computing in Science and Engineering ' 17
High Performance Computing in Science and Engineering ' 17

Author: Wolfgang E. Nagel

Publisher: Springer

Published: 2018-02-16

Total Pages: 522

ISBN-13: 3319683942

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This book presents the state-of-the-art in supercomputer simulation. It includes the latest findings from leading researchers using systems from the High Performance Computing Center Stuttgart (HLRS) in 2017. The reports cover all fields of computational science and engineering ranging from CFD to computational physics and from chemistry to computer science with a special emphasis on industrially relevant applications. Presenting findings of one of Europe’s leading systems, this volume covers a wide variety of applications that deliver a high level of sustained performance.The book covers the main methods in high-performance computing. Its outstanding results in achieving the best performance for production codes are of particular interest for both scientists and engineers. The book comes with a wealth of color illustrations and tables of results.

Multiscale Modeling of Vascular Dynamics of Micro- and Nano-particles
Multiscale Modeling of Vascular Dynamics of Micro- and Nano-particles

Author: Huilin Ye

Publisher: Morgan & Claypool Publishers

Published: 2020-01-02

Total Pages: 112

ISBN-13: 1643277928

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Recent advances witness the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance the efficacy and specificity, the control and guidance of drug carriers in vasculature has become crucial. Current bottlenecks in the optimal design of drug carrying particles are the lack of knowledge about the transport of particles, adhesion on endothelium wall and subsequent internalization into diseased cells. To study the transport and adhesion of particle in vasculature, the authors have made great efforts to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This book discusses the recent achievements from the establishment of fundamental physical problem to development of multiscale model, and finally large scale simulations for understanding transport of particle-based drug carriers in blood flow.

Computational Science – ICCS 2019
Computational Science – ICCS 2019

Author: João M. F. Rodrigues

Publisher: Springer

Published: 2019-06-07

Total Pages: 676

ISBN-13: 3030227340

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The five-volume set LNCS 11536, 11537, 11538, 11539, and 11540 constitutes the proceedings of the 19th International Conference on Computational Science, ICCS 2019, held in Faro, Portugal, in June 2019. The total of 65 full papers and 168 workshop papers presented in this book set were carefully reviewed and selected from 573 submissions (228 submissions to the main track and 345 submissions to the workshops). The papers were organized in topical sections named: Part I: ICCS Main Track Part II: ICCS Main Track; Track of Advances in High-Performance Computational Earth Sciences: Applications and Frameworks; Track of Agent-Based Simulations, Adaptive Algorithms and Solvers; Track of Applications of Matrix Methods in Artificial Intelligence and Machine Learning; Track of Architecture, Languages, Compilation and Hardware Support for Emerging and Heterogeneous Systems Part III: Track of Biomedical and Bioinformatics Challenges for Computer Science; Track of Classifier Learning from Difficult Data; Track of Computational Finance and Business Intelligence; Track of Computational Optimization, Modelling and Simulation; Track of Computational Science in IoT and Smart Systems Part IV: Track of Data-Driven Computational Sciences; Track of Machine Learning and Data Assimilation for Dynamical Systems; Track of Marine Computing in the Interconnected World for the Benefit of the Society; Track of Multiscale Modelling and Simulation; Track of Simulations of Flow and Transport: Modeling, Algorithms and Computation Part V: Track of Smart Systems: Computer Vision, Sensor Networks and Machine Learning; Track of Solving Problems with Uncertainties; Track of Teaching Computational Science; Poster Track ICCS 2019 Chapter “Comparing Domain-decomposition Methods for the Parallelization of Distributed Land Surface Models” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

The Lattice Boltzmann Method
The Lattice Boltzmann Method

Author: Timm Krüger

Publisher: Springer

Published: 2016-11-07

Total Pages: 705

ISBN-13: 3319446495

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This book is an introduction to the theory, practice, and implementation of the Lattice Boltzmann (LB) method, a powerful computational fluid dynamics method that is steadily gaining attention due to its simplicity, scalability, extensibility, and simple handling of complex geometries. The book contains chapters on the method's background, fundamental theory, advanced extensions, and implementation. To aid beginners, the most essential paragraphs in each chapter are highlighted, and the introductory chapters on various LB topics are front-loaded with special "in a nutshell" sections that condense the chapter's most important practical results. Together, these sections can be used to quickly get up and running with the method. Exercises are integrated throughout the text, and frequently asked questions about the method are dealt with in a special section at the beginning. In the book itself and through its web page, readers can find example codes showing how the LB method can be implemented efficiently on a variety of hardware platforms, including multi-core processors, clusters, and graphics processing units. Students and scientists learning and using the LB method will appreciate the wealth of clearly presented and structured information in this volume.

Red Blood Cell Aggregation
Red Blood Cell Aggregation

Author: Oguz Baskurt

Publisher: CRC Press

Published: 2011-09-28

Total Pages: 326

ISBN-13: 1439841802

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Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.

Micro/Nano Devices for Blood Analysis
Micro/Nano Devices for Blood Analysis

Author: Rui A. Lima

Publisher: MDPI

Published: 2019-12-03

Total Pages: 174

ISBN-13: 3039218247

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The development of micro- and nanodevices for blood analysis is an interdisciplinary subject that demands the integration of several research fields, such as biotechnology, medicine, chemistry, informatics, optics, electronics, mechanics, and micro/nanotechnologies. Over the last few decades, there has been a notably fast development in the miniaturization of mechanical microdevices, later known as microelectromechanical systems (MEMS), which combine electrical and mechanical components at a microscale level. The integration of microflow and optical components in MEMS microdevices, as well as the development of micropumps and microvalves, have promoted the interest of several research fields dealing with fluid flow and transport phenomena happening in microscale devices. Microfluidic systems have many advantages over their macroscale counterparts, offering the ability to work with small sample volumes, providing good manipulation and control of samples, decreasing reaction times, and allowing parallel operations in one single step. As a consequence, microdevices offer great potential for the development of portable and point-of-care diagnostic devices, particularly for blood analysis. Moreover, the recent progress in nanotechnology has contributed to its increasing popularity, and has expanded the areas of application of microfluidic devices, including in the manipulation and analysis of flows on the scale of DNA, proteins, and nanoparticles (nanoflows). In this Special Issue, we invited contributions (original research papers, review articles, and brief communications) that focus on the latest advances and challenges in micro- and nanodevices for diagnostics and blood analysis, micro- and nanofluidics, technologies for flow visualization, MEMS, biochips, and lab-on-a-chip devices and their application to research and industry. We hope to provide an opportunity to the engineering and biomedical community to exchange knowledge and information and to bring together researchers who are interested in the general field of MEMS and micro/nanofluidics and, especially, in its applications to biomedical areas.