Comparative studies between HTLV-1 and HTLV-2 function and pathobiology
Comparative studies between HTLV-1 and HTLV-2 function and pathobiology

Author: Umberto Bertazzoni

Publisher: Frontiers Media SA

Published: 2015-06-11

Total Pages: 95

ISBN-13: 2889194981

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Human T-cell leukemia viruses type 1 and 2 (HTLV-1 and HTLV-2) share a common genetic organization, expression strategy and ability to infect and immortalize T-cells in vitro; however, HTLV-1 and HTLV-2 are strikingly different in terms of clinical impact. HTLV-1 is recognized as the aetiological agent of adult T-cell leukemia/lymphoma (ATLL), and HTLV-associated myeolopathy/tropical spastic paraparesis (HAM/TSP), in contrast, HTLV-2 does not cause hematologic disorders and is only sporadically associated with cases of subacute myelopathy. HTLV-1 and HTLV-2 also exhibit distinct cellular tropisms in vivo: HTLV-1 is mainly found in CD4+T lymphocytes, whereas CD8+T-cells are the preferred target for HTLV-2. The articles contributed in this Research Topic are covering all the different aspects that characterize HTLV-1 and HTLV-2, by highlighting differences in their biology that might provide clues to their distinct pathogenic properties.

Molecular Pathology of HTLV-1
Molecular Pathology of HTLV-1

Author: Umberto Bertazzoni

Publisher: Frontiers Media SA

Published: 2019-03-25

Total Pages: 225

ISBN-13: 2889457508

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Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered, in 1980, by Gallo and co-workers. About 5-10% of HTLV-1-infected individuals are at risk of developing either a fatal malignancy, adult T-cell leukemia (ATL), or a chronic neuroinflammatory syndrome, HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Both diseases are incurable at present. Many issues concerning HTLV-1’s life cycle and pathobiology are still unsolved or controversial, and new approaches for prognostic stratification of patients and eradication of HTLV-1 infection are in high demand. In this Research Topic, the focus has been centered on discussing two main themes: the functional analysis and oncogenic potential of HTLV-1 regulatory proteins and the control of HTLV-1-associated diseases. The 22 articles in this eBook cover many different aspects of HTLV-1 infection and pathogenesis, providing new perspectives and groundwork for future studies.

Viral and Immunological Malignancies
Viral and Immunological Malignancies

Author: Paul Volberding

Publisher: PMPH-USA

Published: 2006

Total Pages: 440

ISBN-13: 9781550092561

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The precise relationship between viral infection and malignancy remains an epidemiologic association and the subject of active investigation. Nonmalignant hematologic disorders have a similarly complex relationship with cancer-associated viruses and may offer insight into the pathogenesis of oncogenesis. This book explores the relationships between viral infections, immune impairments and the hematologic and malignant diseases, particularly against the backdrop of the HIV epidemic. By extending the scope to all of viral oncology the editors provide an invaluable resource on tumors related to other viruses other than HIV, particularly carcinomas of the cervix and anus with HPV and tumors of the liver with the various hepatitis viruses.

Human Cancer Viruses
Human Cancer Viruses

Author: John Nicholas

Publisher: Karger Medical and Scientific Publishers

Published: 2008-01-01

Total Pages: 257

ISBN-13: 3805585764

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The first identification of a tumor-causing virus, Rous sarcoma virus, occurred almost 100 years ago, but it was not until the 1970s that the genetic basis for oncogenesis by this and other acutely transforming retroviruses was appreciated. Since then, numerous viral oncogenes and their corresponding cellular proto-oncogene counterparts have been identified, and these studies have contributed much to our understanding of crucially important aspects of cell biology and transformation.This book provides an up-to-date overview of the 6 major viruses that cause human cancers - HPV, HBV, HCV, EBV, KSHV and HTLV-1 - with respect to their molecular biology and epidemiology and to clinical aspects of disease, therapy and prevention. Contributed by over a dozen internationally renowned scientists, the chapters are comprehensively written and illustrated. The book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to understand the mechanisms leading to cellular transformation and oncogenesis by these viruses as a basis for the development of specific therapeutic and antiviral treatments.

Retroviral Proteases
Retroviral Proteases

Author: Lawrence C. Kuo

Publisher: Gulf Professional Publishing

Published: 1994-09-22

Total Pages: 494

ISBN-13: 9780121821425

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Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.

Disease Pathways
Disease Pathways

Author: Anastasia P. Nesterova

Publisher: Elsevier

Published: 2019-10-18

Total Pages: 734

ISBN-13: 0128170875

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Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. - Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. - Disease pathways are based on computational models from Elsevier's Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. - Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

Human T-Cell Lymphotropic Virus Type I
Human T-Cell Lymphotropic Virus Type I

Author: Per Höllsberg

Publisher: John Wiley & Sons

Published: 1996-12-02

Total Pages: 352

ISBN-13:

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HTLV is made up of any of several retroviruses including the retrovirus known as AIDS. Devoted to the rapidly growing field of HTLV, this book explores the many different aspects of the virus.