Companion and Complementary Diagnostics

Companion and Complementary Diagnostics

Author: Jan Trøst Jørgensen

Publisher: Academic Press

Published: 2019-05-08

Total Pages: 508

ISBN-13: 0128135409

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Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation provides readers with in-depth insights into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase straight through to final regulatory approval. Further, the clinical implementation of companion diagnostic testing in the clinic is also discussed. As the development of predictive or selective biomarker assays linked to specific drugs is substantially increasing, this book offers comprehensive information on this quickly-evolving area of biomedicine. It is an essential resource for those in academic institutions, hospitals and pharma, and biotech and diagnostic commercial companies. Covers all aspects, from biomarker discovery, to development and regulatory approval Explains the "how to" aspects of companion diagnostics Incorporates information on the entire process, allowing for easier and deeper understanding of the topic


Precision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence

Author: Michael Mahler

Publisher: Academic Press

Published: 2021-03-12

Total Pages: 300

ISBN-13: 032385432X

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Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions Provides background, milestone and examples of precision medicine Outlines the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using AI Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine


Companion Diagnostics (CDx) in Precision Medicine

Companion Diagnostics (CDx) in Precision Medicine

Author: Il-Jin Kim

Publisher: CRC Press

Published: 2019-03-06

Total Pages: 256

ISBN-13: 1000007219

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There is a new trend in anti-cancer therapeutics development: a targeted therapy and precision medicine that targets a subgroup of patients with specific biomarkers. An in vitro diagnostic (IVD) assay is required to identify a subgroup of cancer patients who would benefit from the targeted therapy, or not likely benefit, or have a high risk of side effects from the specific drug treatment. This IVD or medical device is called a companion diagnostic (CDx) assay. It is key to have a robust CDx assay or device for the success of targeted therapy and precision medicine. This book covers the technical, historical, clinical, and regulatory aspects of CDx in precision medicine. Clearly, more and more newly developed oncology drugs will require accompanying CDx assays, and this book, with chapters contributed by renowned oncologists, provides a comprehensive foundation for the knowledge and application of CDx for precision medicine.


Diagnostic Measurement

Diagnostic Measurement

Author: Andr? A. Rupp

Publisher: Guilford Press

Published: 2010-04-09

Total Pages: 369

ISBN-13: 1606235281

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This book provides a comprehensive introduction to the theory and practice of diagnostic classification models (DCMs), which are useful for statistically driven diagnostic decision making. DCMs can be employed in a wide range of disciplines, including educational assessment and clinical psychology. For the first time in a single volume, the authors present the key conceptual underpinnings and methodological foundations for applying these models in practice. Specifically, they discuss a unified approach to DCMs, the mathematical structure of DCMs and their relationship to other latent variable models, and the implementation and estimation of DCMs using Mplus. The book's highly accessible language, real-world applications, numerous examples, and clearly annotated equations will encourage professionals and students to explore the utility and statistical properties of DCMs in their own projects. This book will appeal to professionals in the testing industry; professors and students in educational, school, clinical, and cognitive psychology. It will also serve as a useful text in doctoral-level courses in diagnostic testing, cognitive diagnostic assessment, test validity, diagnostic assessment, advanced educational measurement, psychometrics, and item response theory


DSM-5 Guidebook

DSM-5 Guidebook

Author: Donald W. Black, M.D.

Publisher: American Psychiatric Pub

Published: 2014-02-01

Total Pages: 570

ISBN-13: 1585624659

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As a companion to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5®), the DSM-5® Guidebook acts as a guide for busy clinicians on the use of diagnostic criteria and codes, documentation, and compensation. It also serves as an educational text and includes a structured curriculum that facilitates its use in courses.


Rickettsial Diseases

Rickettsial Diseases

Author: Didier Raoult

Publisher: CRC Press

Published: 2007-04-26

Total Pages: 400

ISBN-13: 142001997X

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The only available reference to comprehensively discuss the common and unusual types of rickettsiosis in over twenty years, this book will offer the reader a full review on the bacteriology, transmission, and pathophysiology of these conditions. Written from experts in the field from Europe, USA, Africa, and Asia, specialists analyze specific patho


Emergency Psychiatry

Emergency Psychiatry

Author: Rachel L. Glick

Publisher: Lippincott Williams & Wilkins

Published: 2008

Total Pages: 562

ISBN-13: 9780781768733

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Written and edited by leading emergency psychiatrists, this is the first comprehensive text devoted to emergency psychiatry. The book blends the authors' clinical experience with evidence-based information, expert opinions, and American Psychiatric Association guidelines for emergency psychiatry. Case studies are used throughout to reinforce key clinical points. This text brings together relevant principles from many psychiatric subspecialties—community, consultation/liaison, psychotherapy, substance abuse, psychopharmacology, disaster, child, geriatric, administrative, forensic—as well as from emergency medicine, psychology, law, medical ethics, and public health policy. The emerging field of disaster psychiatry is also addressed. A companion Website offers instant access to the fully searchable text. (www.glickemergencypsychiatry.com)


HER2-Positive Breast Cancer

HER2-Positive Breast Cancer

Author: Sara Hurvitz

Publisher: Elsevier Health Sciences

Published: 2018-07-26

Total Pages: 264

ISBN-13: 0323581234

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Get a quick, expert overview of clinically-focused topics and guidelines that are relevant to testing for HER2, which contributes to approximately 25% of breast cancers today. This concise resource by Drs. Sara Hurvitz, and Kelly McCann consolidates today’s available information on this growing topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee oncologists.


Macleod's Clinical Diagnosis E-Book

Macleod's Clinical Diagnosis E-Book

Author: Alan G Japp

Publisher: Elsevier Health Sciences

Published: 2012-10-18

Total Pages: 291

ISBN-13: 0702051225

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Macleod’s Clinical Diagnosis is an innovative new book complementing its companion sister textbook, the internationally-respected Macleod’s Clinical Examination. It is a practical manual of clinical assessment that describes how common presenting problems are evaluated and diagnosed in modern clinical practice. This book will be an invaluable resource for senior medical students and junior doctors as they attempt to make the difficult transition from mastering basic clinical skills to assessing patients in the real world of clinical medicine. The format of the book is as follows: Part 1: The principles of clinical assessment: in addition to defining the scope and remit of the book this initial group of chapters invites readers to reconsider the overall aims of clinical assessment, the contribution that each element of the assessment can make to these aims and how the approach must be adapted to fit the clinical context. It also touches on diagnostic theory and explains some different approaches to diagnosis. Part 2: How to assess common presenting problems: this section forms the core of the book and consists of a series of ‘diagnostic guides’ covering the major presenting problems in medicine and surgery; these provide the reader with a system for how to use the tools of history-taking, physical examination and routine tests to arrive at a logical differential diagnosis. The guides also cover some limited ‘post-diagnosis information’ in the form of severity/prognostic indicators. A unique book allowing a reader to apply the skills of clinical examination in the formulation of a differential diagnosis and placing a patient’s symptoms in context. Takes a problem-based approach to diagnostic reasoning, reflecting both modern medical and current educational practices. Builds on the clinical skills outlined in the companion Macleod’s Clinical Examination textbook.