Combinatorial Chemistry on Solid Supports
Author: Stefan Braese
Publisher: Springer
Published: 2007-06-23
Total Pages: 370
ISBN-13: 3540725105
DOWNLOAD EBOOKWith contributions by numerous experts
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Combinatorial Chemistry
Author: Stephen R. Wilson
Publisher: John Wiley & Sons
Published: 1997-03-28
Total Pages: 288
ISBN-13: 9780471126874
DOWNLOAD EBOOKThe new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.
Solid-supported Combinatorial and Parallel Synthesis of Small-molecular-weight Compound Libraries
Author: D. Obrecht
Publisher: Elsevier
Published: 1998-10-16
Total Pages: 366
ISBN-13: 9780080432571
DOWNLOAD EBOOKThis book gives an overview of the current state of the art of combinatorial organic synthesis. While the main focus is on multicomponent and multigeneration strategies using polymeric supports, there is also a Chapter on solution strategies using polymer-grafted reagents which allow minimisation of work-up procedures. Some of the most important strategies and tools are presented and summarised, with an explanation of the pivotal role of organic synthesis in the creation of diversity.
Combinatorial Chemistry, Part B
Author:
Publisher: Elsevier
Published: 2004-01-26
Total Pages: 607
ISBN-13: 0080497101
DOWNLOAD EBOOKCombinatorial Chemistry encompasses both the design of compounds for specific pharmacological use and the screening of molecules in high throughput automated tests to find active agents with specific functions. *Analytical techniques*Direct sorting split and pool combinatorial synthesis*Linkers and their applications*Microwave assisted synthesis*Oligosaccharide chemistry*Peptide Synthesis and Screening*Polymer assisted approaches*Small molecule and heterocycle synthesis
Optimization of Solid-Phase Combinatorial Synthesis
Author: Bing Yan
Publisher: CRC Press
Published: 2001-12-04
Total Pages: 408
ISBN-13: 1482271052
DOWNLOAD EBOOK"Addresses the key topic in combinatorial synthesis--how to optimize the quality of a combinatorial library--by determining the usefulness of synthesized compunds, the reliability of biological assay results, and analyzing acadmic and industrial applications, real-world examples, and case studies of successful and unsuccessful technologies."
Combinatorial Chemistry
Author: Guillermo A. Morales
Publisher: Academic Press
Published: 2003
Total Pages: 608
ISBN-13: 0121822729
DOWNLOAD EBOOKCombinatorial Chemistry encompasses both the design of compounds for specific pharmacological use and the screening of molecules in high throughput automated tests to find active agents with specific functions. *Analytical techniques *Direct sorting split and pool combinatorial synthesis *Linkers and their applications *Microwave assisted synthesis *Oligosaccharide chemistry *Peptide Synthesis and Screening *Polymer assisted approaches *Small molecule and heterocycle synthesis.
Combinatorial Chemistry
Author: Willi Bannwarth
Publisher: John Wiley & Sons
Published: 2006-05-12
Total Pages: 694
ISBN-13: 3527607382
DOWNLOAD EBOOKThe new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. "Experimental details and complete reaction data [...] are a constant theme running through this work" (Angewandte Chemie) "Recommended to newcomers in the field of combinatorial chemical synthesis because of its broad scope" (Journal of the American Chemical Society)
Combinatorial Chemistry
Author: Willi Bannwarth
Publisher: John Wiley & Sons
Published: 2009-08-14
Total Pages: 450
ISBN-13: 352761415X
DOWNLOAD EBOOKAs we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. Combinatorial chemistry has rapidly become the rising star among research methods, allowing scientists to efficiently test the feasibility of a multitude of new compounds. The pursuit of new drugs is but one challenging field in which these combinatorial methods are particularly advantageous, helping researchers meet the modern-day demands of a highly competitive environment. This book emphasises that modern combinatorial synthesis is possible not only in the solid phase, but also in solutions. Moreover, it discusses computer-assisted methods as well as the apparatus and instrumentation required for the combinatorial method. Successful and experienced researchers in the leading pharmaceutical companies and most renowned research institutes offer a solid insight and perspective into this diverse field. A 'must' for every scientist in the area of pharmaceutical research
Combinatorial Chemistry and Technology
Author: Stanislav Miertus
Publisher: CRC Press
Published: 1999-07-01
Total Pages: 456
ISBN-13: 9781420000566
DOWNLOAD EBOOK"Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."
Combinatorial Chemistry and Technologies
Author: Stanislav Miertus
Publisher: CRC Press
Published: 2005-04-12
Total Pages: 616
ISBN-13: 0824758374
DOWNLOAD EBOOKSeveral books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the methodologies used in the design, synthesis, and screening of molecular libraries. Now in its second edition, this volume updates prior content and explores new areas such as catalysis, applications in biotechnology, and current ICS-UNIDO activities. Topics include the generation of molecular diversity by chemical methods using solution- and solid-phase chemistries, biological approaches for the production and screening of peptides, antibody and oligonucleotide libraries, and the application of computer-assisted approaches to guide library synthesis. The book establishes the link between combinatorial chemistry and molecular modeling and illustrates the importance of economics and patenting in combinatorial technologies. Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new materials, and catalysis.
