Fundamentals of Clinical Data Science
Fundamentals of Clinical Data Science

Author: Pieter Kubben

Publisher: Springer

Published: 2018-12-21

Total Pages: 219

ISBN-13: 3319997130

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This open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare. Fundamentals of Clinical Data Science is an essential resource for healthcare professionals and IT consultants intending to develop and refine their skills in personalized medicine, using solutions based on large datasets from electronic health records or telemonitoring programmes. The book’s promise is “no math, no code”and will explain the topics in a style that is optimized for a healthcare audience.

Pathology: A Modern Case Study
Pathology: A Modern Case Study

Author: Howard Reisner

Publisher: McGraw Hill Professional

Published: 2014-09-22

Total Pages: 622

ISBN-13: 0071821236

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A unique case-based molecular approach to understanding pathology Pathology: A Modern Case Study is a concise, focused text that emphasizes the molecular and cellular biology essential to understanding the concepts of disease causation. The book includes numerous case studies designed to highlight the role of the pathologist in the team that provides patient care. Pathology: A Modern Case Study examines the role of anatomic, clinical, and molecular pathologists in dedicated chapters and in descriptions of the pathology of specific organ systems. Features Coverage of pathology focuses on modern approaches to common and important diseases Each chapter delivers the most up-to-date advances in pathology Learning aids include chapter summaries and overviews, bolded terms, and a glossary Common clinically relevant disease are highlighted Disease discussion is based on organ compartment and etiology Coverage includes: Disease and the Genome: Genetic, Developmental and Neoplastic Disease Cell Injury, Death and Aging and the Body's Response Environmental Injury Clinical Practice: Anatomic Pathology Clinical Practice: Molecular Pathology Clinical Practice: Molecular Pathology Organ-specific pathology covering all major body systems Molecular pathology Essential for undergraduate medical students and clinicians who wish to expand their knowledge pathology, Pathology: A Modern Case Study delivers valuable coverage that is directly related to a patient’s condition and the clinical practice of pathology.

Endogenous Interferences in Clinical Laboratory Tests
Endogenous Interferences in Clinical Laboratory Tests

Author: Martin H. Kroll

Publisher: Walter de Gruyter

Published: 2012-12-19

Total Pages: 155

ISBN-13: 3110266229

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The goal of clinical laboratories is to produce accurate information for clinical decision making in medicine. More than half of the medical decisions made depend on clinical laboratory tests. Patient safety represents an important and critical problem for laboratories. They need to assure that the information they deliver to physicians is accurate, and therefore safe for clinicians to use. Endogenous compounds can interfere with laboratory tests, decreasing accuracy and threatening patient safety. Elevated bilirubin (bilirubinemia) and elevated lipids (lipemia) are common conditions that cause significant interferences with laboratory results. Clinicians depend on laboratories to detect these endogenous interferences. Laboratories must have a means to detect these endogenous interferences, make decisions about reporting results, and evaluate their impact. Most clinical pathology books provide only an abbreviated introduction to the subject, or provide a long list of references, without the necessary foundation for evaluating their significance. Package inserts typically provide scant information. This book provides the empirical and theoretical foundation for these interferences, describes the clinical settings where they occur, and explains their evaluation and detection, allowing the laboratory to interpret the available data on interferences and make the appropriate decision to effectively report test results while protecting patient safety.

Evolution of Translational Omics
Evolution of Translational Omics

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2012-09-13

Total Pages: 354

ISBN-13: 0309224187

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Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Clinical Laboratory Medicine
Clinical Laboratory Medicine

Author: Kenneth D. McClatchey

Publisher: Lippincott Williams & Wilkins

Published: 2002

Total Pages: 1732

ISBN-13: 9780683307511

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This thoroughly updated Second Edition of Clinical Laboratory Medicine provides the most complete, current, and clinically oriented information in the field. The text features over 70 chapters--seven new to this edition, including medical laboratory ethics, point-of-care testing, bone marrow transplantation, and specimen testing--providing comprehensive coverage of contemporary laboratory medicine. Sections on molecular diagnostics, cytogenetics, and laboratory management plus the emphasis on interpretation and clinical significance of laboratory tests (why a test or series of tests is being done and what the results mean for the patient) make this a valuable resource for practicing pathologists, residents, fellows, and laboratorians. Includes over 800 illustrations, 353 in full color and 270 new to this edition. Includes a Self-Assessment and Review book.