Clinical Approach to Sudden Cardiac Death Syndromes
Clinical Approach to Sudden Cardiac Death Syndromes

Author: Ramon Brugada

Publisher: Springer Science & Business Media

Published: 2010-01-18

Total Pages: 340

ISBN-13: 1848829272

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Clinical cardiologists are encountering an important challenge in the caring of families with inherited cardiac diseases. The majority of the inherited cardiac diseases causing sudden death express themselves at variable ages in the form of altered muscle function (i.e hypertrophic or dilated cardiomyopathy) or in the form of arrhythmias (i.e. Brugada syndrome, long QT syndrome). However, it is not uncommon that the first sign of the disease may actually be sudden cardiac death, even before the identification of clear clinical abnormalities. In this last decade, with more than 50 new disease-associated genes identified, the possibility of genetic testing has opened a new opportunity to disease diagnosis and prevention. Clinical and genetic research is continuously on-going not only to identify those at risk, but to better define their level or risk still with limited success.

The Brugada Syndrome
The Brugada Syndrome

Author: Charles Antzelevitch

Publisher: John Wiley & Sons

Published: 2008-04-15

Total Pages: 248

ISBN-13: 1405146818

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Until recently, the cellular basis for sudden death, the BrugadaSyndrome, has largely remained an unknown to modernarrhythmologists and cardiologists, particularly in the absence ofany structural heart disease. Detailed observations of age-groups,especially the young, families and populations where sudden deathfrequently occurs, and improved understanding of its contributoryfactors and mechanisms are, however, showing the way forward. This addition to the Clinical Approaches to Tachyarrhythmias(CATA) Series, written by the investigators who discovered andprobed the Brugada Syndrome, discusses the history, etiology,pathology and clinical manifestations of sudden death. Fromdiagnosis, prognosis, to therapeutic approaches using the latest incathater ablation techniques, electrophysiological surgery, andgenetic appraisal, the work is a testimony to the author'sinvestigation. Using clinical cases in Thailand and Laos, theyfurther unravel the syndrome's molecular mechanisms, studyingrelated syndromes, such as the long-QT syndrome, infant death, andarryhthmogenic right ventricular cardiomyopathy. By being informed of the electrophysiological abnormalities thatcontribute to familial and genetic diseases, physicians,cardiologists and all those who care for patients with cardiacarrhythmias will be better able to identify and treat patients inwhom the Brugada Syndrome may strike next.

J Wave Syndromes
J Wave Syndromes

Author: Charles Antzelevitch

Publisher: Springer

Published: 2016-06-27

Total Pages: 342

ISBN-13: 3319315781

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This book delineates the state of the art of the diagnosis and treatment of J wave syndromes, as well as where future research needs to be directed. It covers basic science, translational and clinical aspects of these syndromes. The authors are leading experts in their respective fields, who have contributed prominently to the literature concerning these topics. J wave syndromes are one of the hottest topics in cardiology today. Cardiac arrhythmias associated with Brugada syndrome (BrS) or an early repolarization (ER) pattern in the inferior or infero-lateral ECG leads are thought to be mechanistically linked to accentuation of transient outward current (Ito)-mediated J waves. Although BrS and ER syndrome (ERS) differ with respect to magnitude and lead location of abnormal J waves, they are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. ERS is divided into three subtypes with the most severe, Type 3, displaying an ER pattern globally in the inferior, lateral and right precordial leads. BrS has been linked to mutations in 19 different genes, whereas ERS has been associated with mutations in 7 different genes. There is a great deal of confusion as to how to properly diagnose and treat the J wave syndromes as well as confusion about the underlying mechanisms. The demonstration of successful epicardial ablation of BrS has provided new therapeutic options for the management of this syndrome for which treatment alternatives are currently very limited, particularly in the case of electrical storms caused by otherwise uncontrollable recurrent VT/VF. An early repolarization pattern is observed in 2-5% of the US population. While it is clear that the vast majority of individuals exhibiting an ER pattern are not at risk for sudden cardiac death, the challenge moving forward is to identify those individuals who truly are at risk and to design safe and effective treatments.

Sudden Cardiac Death
Sudden Cardiac Death

Author: Ivana Vranic

Publisher:

Published: 2017

Total Pages: 0

ISBN-13: 9781536119831

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This is a detailed clinical compilation on sudden cardiac death causes. From the various geographical regions of the world comes different clinical perspectives toward the SCD problem that shed light on the predictors and estimated prevalence in genetic inheritance worldwide. For many centuries, the mysterious deaths of prominent professional sportsmen have preoccupied the attention of the media and medical professionals. In some cases, it was possible to obtain the medical histories of the victims, data on the presence of some specific diseases, and conditions or potential symptoms preceding the fatal episode. Various rare inherited syndromes that are associated with congenital heart disease are focused on in this study, and the interrelationship between ventricular premature beats, sustained/non-sustained ventricular tachycardias and ventricular fibrillations are discussed. Cardio-oncology is an emerging field where more and more patients face consequences from radiotherapy and chemotherapy because these individuals become more prone to SCD. Among the most notable developments, three-dimensional echocardiography and myocardial strain imaging are worth noting and might inexpensively improve the current risk stratification process. Recently, a strain that reflects the change of length and thickness of myocardial fibres has been incorporated into the routine clinical practice. The risk of sudden cardiac death is not the same in patients with Chagas disease, and newly predicted factors are to blame. The prevalence of SCD, hypertrophic cardiomyopathy and the accurate risk are extremely challenging, so much so that they recently became a source of argument between European and American experts. This is a must-have book for those interested in a clinical approach to the SCD phenomenon.

Molecular Cardiology
Molecular Cardiology

Author: Zhongjie Sun

Publisher: Springer Science & Business Media

Published: 2008-02-01

Total Pages: 410

ISBN-13: 159259879X

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The aim of Molecular Cardiology: Methods and Protocols is to document state-of-the-art molecular and genetic techniques in the area of cardiology. These modern approaches enable researchers to readily study heart diseases at the molecular level and will promote the development of new therapeutic str- egies. Methods for genetic dissection, signal transduction, and microarray analysis are excellent tools for the study of the molecular mechanisms of cardiovascular diseases. Protocols for transgenesis take advantage of recent advances in many areas of molecular and cell biology. Transgenic models of heart diseases (cardiac hypertrophy, cardiac dysfunction, and so on. ) are powerful tools for the study of heart disease pathogenesis. Methods for gene transfer to heart tissue using viral and nonviral vectors form the basis of gene therapy for heart diseases. Heart-specific promoters containing a hypox- inducible cardioprotective gene switch are key for protection of the heart from ischemia. Gene and stem cell therapies open novel and exciting avenues for the prevention and treatment of heart diseases. Molecular Cardiology: Methods and Protocols consists of 26 chapters de- ing with various aspects of molecular cardiology, including gene transfer and gene therapy for cardiovascular disease, stem cell therapy for cardiovascular disease, gene analysis in the injured and hypertrophied heart, and transgenesis in cardiovascular research. This book provides step-by-step methods for the successful completion of experimental procedures, and would be useful for both experienced and new investigators in the field of molecular cardiology.

Brugada Phenocopy
Brugada Phenocopy

Author: Adrian Baranchuk

Publisher: Academic Press

Published: 2018-03-28

Total Pages: 158

ISBN-13: 0128111526

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Brugada Phenocopy: The Art of Recognizing the Brugada ECG Pattern details all aspects associated with alternative diagnosis to Brugada Syndrome (BrS). Coverage includes how to identify the proper ECG pattern, what to do to investigate for BrP, and how to avoid misinterpretations and the use of unnecessary and expensive treatments. Chapters are written by experienced professionals, many of whom are colleagues that initially described this condition. This easy to use volume is a must have reference for researchers of cardiology, cardiologists, electrocardiologists, internists, emergency care doctors and students, residents and fellows. - Assists in the proper recognition of the Brugada ECG patterns and how to distinguish true BrS from other conditions with identical ECG - Expands understanding on how to properly recognize the ECG of Brugada patterns - Contains access to a companion website with video to enhance understanding of proper measurement of the beta angle (Chevallier) and the base of the triangle (Serra)

Ventricular Arrhythmias
Ventricular Arrhythmias

Author: John M. Miller

Publisher:

Published: 2008

Total Pages: 0

ISBN-13: 9781416062752

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Ventricular arrhythmias cause most cases of sudden cardiac death, which is the leading cause of death in the US. This issue reviews the causes of arrhythmias and the promising new drugs and devices to treat arrhythmias.

Professor Hein J.J. Wellens: 33 Years of Cardiology and Arrhythmology
Professor Hein J.J. Wellens: 33 Years of Cardiology and Arrhythmology

Author: J. Smeets

Publisher: Springer Science & Business Media

Published: 2000-03-31

Total Pages: 702

ISBN-13: 9780792362098

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The first invasive evaluation of cardiac arrhythmias in humans was performed in 1967 in Paris (Prof. P. Coumel) and Amsterdam (Prof. D. Durrer). This was the start of a rapid increase in our knowledge of the diagnosis, mechanism and treatment of cardiac arrhythmias. In that same year Prof. Hein J.J. Wellens became cardiologist in the Wilhelmina Gasthuis in Amsterdam. Initially in Amsterdam (1967-1977) and later on in Maastricht (from 1977), he was the driving force for many breakthroughs in clinical cardiac electrophysiology. With an active interplay between the knowledge derived from the 12-lead electrocardiogram and the recordings made with invasive electrophysiology, he composed new ideas leading to major contributions in clinical cardiac electrophysiology and, more generally, in arrhythmology. He published over 650 scientific papers and 14 books, and had numerous functions within scientific boards of prestigious journals. In addition he trained more than 120 cardiologists in clinical cardiac electrophysiology. On the occasion of the congress `2000, Future of Arrhythmology: Lessons From the Past, Promises For Tomorrow', we highlight the scientific work of Prof. Hein J.J. Wellens. A selection of more than 60 articles over the whole time span has been selected. These articles are accompanied by comments from an expert, co-worker and/or former fellow in order to place the paper in a scientific time frame, including the relationship of the author with Prof. Hein J.J. Wellens.

Strategies to Improve Cardiac Arrest Survival
Strategies to Improve Cardiac Arrest Survival

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2015-09-29

Total Pages: 291

ISBN-13: 030937202X

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Cardiac arrest can strike a seemingly healthy individual of any age, race, ethnicity, or gender at any time in any location, often without warning. Cardiac arrest is the third leading cause of death in the United States, following cancer and heart disease. Four out of five cardiac arrests occur in the home, and more than 90 percent of individuals with cardiac arrest die before reaching the hospital. First and foremost, cardiac arrest treatment is a community issue - local resources and personnel must provide appropriate, high-quality care to save the life of a community member. Time between onset of arrest and provision of care is fundamental, and shortening this time is one of the best ways to reduce the risk of death and disability from cardiac arrest. Specific actions can be implemented now to decrease this time, and recent advances in science could lead to new discoveries in the causes of, and treatments for, cardiac arrest. However, specific barriers must first be addressed. Strategies to Improve Cardiac Arrest Survival examines the complete system of response to cardiac arrest in the United States and identifies opportunities within existing and new treatments, strategies, and research that promise to improve the survival and recovery of patients. The recommendations of Strategies to Improve Cardiac Arrest Survival provide high-priority actions to advance the field as a whole. This report will help citizens, government agencies, and private industry to improve health outcomes from sudden cardiac arrest across the United States.