Alphaherpesviruses
Alphaherpesviruses

Author: Sandra Knowles Weller

Publisher: Caister Academic Press Limited

Published: 2011

Total Pages: 0

ISBN-13: 9781904455769

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Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.

Yvain
Yvain

Author: Chretien de Troyes

Publisher: Yale University Press

Published: 1987-09-10

Total Pages: 242

ISBN-13: 0300187580

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The twelfth-century French poet Chrétien de Troyes is a major figure in European literature. His courtly romances fathered the Arthurian tradition and influenced countless other poets in England as well as on the continent. Yet because of the difficulty of capturing his swift-moving style in translation, English-speaking audiences are largely unfamiliar with the pleasures of reading his poems. Now, for the first time, an experienced translator of medieval verse who is himself a poet provides a translation of Chrétien’s major poem, Yvain, in verse that fully and satisfyingly captures the movement, the sense, and the spirit of the Old French original. Yvain is a courtly romance with a moral tenor; it is ironic and sometimes bawdy; the poetry is crisp and vivid. In addition, the psychological and the socio-historical perceptions of the poem are of profound literary and historical importance, for it evokes the emotions and the values of a flourishing, vibrant medieval past.

Space Biology and Medicine
Space Biology and Medicine

Author: Arnauld E. Nicogossian

Publisher: AIAA (American Institute of Aeronautics & Astronautics)

Published: 1993

Total Pages: 456

ISBN-13: 9781563470820

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Volume II in the Space Biology and Medicine series, Life Support and Habitability addresses major issues and requirements for safe habitability and work beyond the Earths atmosphere. It is composed of two parts: The Spacecraft Environment and Life Support Systems. As in the first volume, the authors are specialists in their fields in the United States and Russian Federation. The book is intended for a widespread audience. In particular, it will appeal to students majoring in biomedical and technical subjects who intend to specialize in space science, engineers developing life support systems, and physicians and scientists formulating medical specifications for habitability conditions onboard spacecraft and monitoring compliance with them. There are more than 285 figures and tables and 1100 references.

Making Rounds with Oscar
Making Rounds with Oscar

Author: David Dosa

Publisher: Hachette UK

Published: 2010-02-02

Total Pages: 240

ISBN-13: 1401394965

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A remarkable cat. A special gift. A life-changing journey. They thought he was just a cat. When Oscar arrived at the Steere House Nursing and Rehabilitation Center in Rhode Island he was a cute little guy with attitude. He loved to stretch out in a puddle of sunlight and chase his tail until he was dizzy. Occasionally he consented to a scratch behind the ears, but only when it suited him. In other words, he was a typical cat. Or so it seemed. It wasn't long before Oscar had created something of a stir. Apparently, this ordinary cat possesses an extraordinary gift: he knows instinctively when the end of life is near. Oscar is a welcome distraction for the residents of Steere House, many of whom are living with Alzheimer's. But he never spends much time with them -- until they are in their last hours. Then, as if this were his job, Oscar strides purposely into a patient's room, curls up on the bed, and begins his vigil. Oscar provides comfort and companionship when people need him most. And his presence lets caregivers and loved ones know that it's time to say good-bye. Oscar's gift is a tender mercy. He teaches by example: embracing moments of life that so many of us shy away from. Making Rounds with Oscar is the story of an unusual cat, the patients he serves, their caregivers, and of one doctor who learned how to listen. Heartfelt, inspiring, and full of humor and pathos, this book allows readers to take a walk into a world rarely seen from the outside, a world we often misunderstand.