Regulation of Tissue Oxygenation, Second Edition
Regulation of Tissue Oxygenation, Second Edition

Author: Roland N. Pittman

Publisher: Biota Publishing

Published: 2016-08-18

Total Pages: 117

ISBN-13: 1615047212

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This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

The Cerebral Circulation
The Cerebral Circulation

Author: Marilyn J. Cipolla

Publisher: Biota Publishing

Published: 2016-07-28

Total Pages: 82

ISBN-13: 1615047239

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This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Protean Power
Protean Power

Author: Peter J. Katzenstein

Publisher: Cambridge University Press

Published: 2018-01-18

Total Pages: 383

ISBN-13: 1108425178

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Mainstream international relations continues to assume that the world is governed by calculable risk based on estimates of power, despite repeatedly being surprised by unexpected change. This ground breaking work departs from existing definitions of power that focus on the actors' evolving ability to exercise control in situations of calculable risk. It introduces the concept of 'protean power', which focuses on the actors' agility as they adapt to situations of uncertainty. Protean Power uses twelve real world case studies to examine how the dynamics of protean and control power can be tracked in the relations among different state and non-state actors, operating in diverse sites, stretching from local to global, in both times of relative normalcy and moments of crisis. Katzenstein and Seybert argue for a new approach to international relations, where the inclusion of protean power in our analytical models helps in accounting for unforeseen changes in world politics.

The Mind and Society
The Mind and Society

Author: Vilfredo Pareto

Publisher: Natal Publishing, LLC

Published: 2024-01-13

Total Pages: 0

ISBN-13:

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Dive into the profound insights of Vilfredo Pareto in The Mind and Society, a timeless exploration of human behavior and social dynamics. Pareto's keen observations and analytical brilliance illuminate the complex interplay of power, elites, and the intricate web that shapes the mind and structures of our societies.

Patterns in Circulation
Patterns in Circulation

Author: Nina Sylvanus

Publisher: University of Chicago Press

Published: 2016-12-07

Total Pages: 0

ISBN-13: 9780226397191

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In this book, Nina Sylvanus tells a captivating story of global trade and cross-cultural aesthetics in West Africa, showing how a group of Togolese women—through the making and circulation of wax cloth—became influential agents of taste and history. Traveling deep into the shifting terrain of textile manufacture, design, and trade, she follows wax cloth around the world and through time to unveil its critical role in colonial and postcolonial patterns of exchange and value production. Sylvanus brings wax cloth’s unique and complex history to light: born as a nineteenth-century Dutch colonial effort to copy Javanese batik cloth for Southeast Asian markets, it was reborn as a status marker that has dominated the visual economy of West African markets. Although most wax cloth is produced in China today, it continues to be central to the expression of West African women’s identity and power. As Sylvanus shows, wax cloth expresses more than this global motion of goods, capital, aesthetics, and labor—it is a form of archive where intimate and national memories are stored, always ready to be reanimated by human touch. By uncovering this crucial aspect of West African material culture, she enriches our understanding of global trade, the mutual negotiations that drive it, and the how these create different forms of agency and subjectivity.