Chromatographic and Membrane Processes in Biotechnology

Chromatographic and Membrane Processes in Biotechnology

Author: C.A. Costa

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 465

ISBN-13: 9401134707

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Separation processes in biotechnology are of increasing industrial importance since they entail the major costs of bioprocessing especially when high purity is required. Chromatography and membranes are two of the most important technologies used for direct treatment of fermentation broths as well as for high resolution steps in product purification. The theoretical foundations of chromatographic and membrane processes are well understood for the case of small molecules. Nevertheless there is a need to adapt and further develop that knowledge to the processing of large biological molecules. This is being achieved with the contribution of other areas like molecular biology and materials science. The objective of this NATO Advanced Study Institute is to present an updated treatment of the fundamentals of chromatographic and membrane processes with special relevance in bioprocessing.This volume collects the lectures presented at this Institute. The lectures are arranged in five chapters. Chapter I deals with chromatographic processes covering topics like equilibrium, kinetics and contacting devices. Membrane processes and some applications in biotechnology are treated in chapter 2. Chapter 3 is devoted to affinity chromatographic and membrane processes. Chapter 4 considers the current developments on chromatographic supports and membranes both from the constitutive materials and form points of view. Scale-up, optimization and reaction/separation integration are the topics covered in chapter 5. We are very grateful to all lecturers and participants that made possible this Institute. Financial support from NATO Scientific Affairs Division, INIC, JNICT, FLAD, University of Ac;ores and DRT Ac;ores is gratefully acknowledged.


Membrane Processes in Biotechnology and Pharmaceutics

Membrane Processes in Biotechnology and Pharmaceutics

Author: Catherine Charcosset

Publisher: Elsevier

Published: 2012-01-25

Total Pages: 349

ISBN-13: 0444563377

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Membrane processes are increasingly used in pharmaceutical and biochemical engineering and biotechnology for concentration and purification, synthesis of molecules and drug delivery systems, and support for biochemical reactions. This book provides a state-of-the art overview of the classical membrane processes used in pharmaceutical and biochemical engineering and biotechnology, such as ultrafiltration, microfiltration, virus filtration, membrane chromatography, membrane emulsification, liquid membranes and membrane bioreactors. It describes the general rules (principles, choice of configurations, membranes, parameters, etc.), recent developments (fouling control, increase permeate flux and selectivity, etc.), applications, and theoretical descriptions. Further, it presents emerging processes such as solvent resistant nanofiltration and membrane crystallization. Presents classical membrane processes such as ultrafiltration, microfiltration, virus filtration, membrane chromatography, membrane emulsification, liquid membranes and membrane bioreactors Presents emerging processes such as solvent resistant nanofiltration and membrane crystallization Gives a complete description of each technique (principles, membrane materials and devices, fouling control, and theoretical description) Contains numerous examples of applications Includes a uniform notation throughout the book enhancing the presentation and understanding of the content Includes extensive list of references


Handbook of Membrane Separations

Handbook of Membrane Separations

Author: Anil Kumar Pabby

Publisher: CRC Press

Published: 2015-04-09

Total Pages: 868

ISBN-13: 1466555580

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The Handbook of Membrane Separations: Chemical, Pharmaceutical, Food, and Biotechnological Applications, Second Edition provides detailed information on membrane separation technologies from an international team of experts. The handbook fills an important gap in the current literature by providing a comprehensive discussion of membrane application


Membrane Separations in Biotechnology

Membrane Separations in Biotechnology

Author: William K. Wang

Publisher: CRC Press

Published: 2001-04-03

Total Pages: 432

ISBN-13: 1482289881

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This text details the relationship between membrane technology and bioprocesses, discussing applications. This second edition refines and optimizes key features of the first edition - and features new illustrative case studies. The book examines advantages and disadvantages of using standard and new membrane technologies; analyzes a wide range of a


Handbook of Membrane Separations

Handbook of Membrane Separations

Author: Anil K. Pabby

Publisher: CRC Press

Published: 2008-07-07

Total Pages: 1210

ISBN-13: 0849395496

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The Handbook of Membrane Separations: Chemical, Pharmaceutical, and Biotechnological Applications provides detailed information on membrane separation technologies as they have evolved over the past decades. To provide a basic understanding of membrane technology, this book documents the developments dealing with these technologies. It explores chemical, pharmaceutical, food processing and biotechnological applications of membrane processes ranging from selective separation to solvent and material recovery. This text also presents in-depth knowledge of membrane separation mechanisms, transport models, membrane permeability computations, membrane types and modules, as well as membrane reactors.


Separation Processes in Biotechnology

Separation Processes in Biotechnology

Author: Juan A. Asenjo

Publisher: CRC Press

Published: 2020-08-26

Total Pages: 824

ISBN-13: 100010432X

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Edited to avoid duplication and favor comprehensiveness, 20 contributors detail the recovery, separation, and purification operations of bioprocess technology. Individual chapters in this classic yet still highly relevant work emphasize concepts that are becoming more and more important when applied to the large scale versions of techniques that are considered well established. Aside from fully discussing processes, Separation Processes in Biotechnology includes sections on concentration separation and operation, purification operations, and product release and recovery. It also discusses plant operation and equipment and delves into economic considerations


Current Trends and Future Developments on (Bio-) Membranes

Current Trends and Future Developments on (Bio-) Membranes

Author: Angelo Basile

Publisher: Elsevier

Published: 2018-10-16

Total Pages: 368

ISBN-13: 0128136073

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Current Trends and Future Developments on (Bio-) Membranes: Membrane Processes in the Pharmaceutical and Biotechnological field presents the main membrane techniques along with their basic principles, mode of operations, and applications. It covers well-known techniques such as ultrafiltration and membrane chromatography, while also exploring emerging membrane technologies which are finding their way in pharmaceutical and biotechnology industries, including membrane emulsification, membrane bioreactors, and solvent-resistant nanofiltration. State-of-the-art applications of membrane systems in areas such as drug delivery and virus removal are also investigated by leading experts in the field. Current Trends and Future Developments on (Bio-) Membranes: Membrane Processes in the Pharmaceutical and Biotechnological field is a definitive reference for academics, post-graduates, and researchers in the subjects of biochemical engineering, pharmaceutics, and biotechnology. It is also useful to R&D companies and institutions in these areas, specifically those interested in bioseparations, biopurification, bioproduction, and drug delivery. Offers an overview of classical membrane-based separation techniques such as ultrafiltration, microfiltration and virus filtration Discusses emerging membrane-based separation techniques such as nofiltration in the presence of solvent, membrane emulsification and membrane crystallization Outlines their applications to bioseparation, biopurification and bioproduction Includes examples in the production of vaccines, antibiotics, biomolecules, drugs, DNA and cells Lists membranes systems for drug delivery like liposomes, nanocapsules and bilayer membranes


Highly Selective Separations in Biotechnology

Highly Selective Separations in Biotechnology

Author: G. Street

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 242

ISBN-13: 940111322X

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Success in meeting the challenge to produce the commercial products anticipated by the exploitation of biological processes depends upon provid ing effective separation protocols. Effectiveness can be measured in terms of selectivity, purity, resolution and validatory success. The major processing problems are associated with either the selective recovery of molecules which are present in low concentrations from complex mixtures or the selective removal of contaminants from the desired molecule. Central to the evolution of processes satisfying this demand are the regulatory requirements being imposed by governments on the purity of a product, especially in the health care market. Synthetic organic chemists are increasingly finding it advantageous to conduct one or more steps using either enzymic biotransformations where molecules with a single and consistent stereochemistry or chirality are required. The underlying princi ples behind the methods, techniques and processes currently being used and developed commercially rely upon the biospecific nature and properties of the desired molecule. When these factors are married to the more traditional techniques of precipitation, chromatography, liquid-liquid extraction and membrane processes, powerful tools emerge, allowing highly selective separations to be designed. The logical extension of these combinations is to apply genetic engineering techniques to influence the separations at a more fundamental and structural level by modifying the target protein at source, during its synthesis, to facilitate its separation in a given, selective manner, leading to the distinct possibility of producing 'designer' separation programmes.


Process Scale Bioseparations for the Biopharmaceutical Industry

Process Scale Bioseparations for the Biopharmaceutical Industry

Author: Abhinav A. Shukla

Publisher: CRC Press

Published: 2006-07-07

Total Pages: 600

ISBN-13: 1420016024

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The biopharmaceutical industry has become an increasingly important player in the global economy, and the success of these products depends on the development and implementation of cost-effective, robust and scaleable production processes. Bioseparations-also called downstream processing- can be a key source of competitive advantageto biopharmaceut


Bioseparation and Bioprocessing, Volume I: Biochromatography - Membrane Separations - Modeling - Validation. Volume II: Processing - Quality and Characterisation - Economics, Safety and Hygiene

Bioseparation and Bioprocessing, Volume I: Biochromatography - Membrane Separations - Modeling - Validation. Volume II: Processing - Quality and Characterisation - Economics, Safety and Hygiene

Author: G. Subramanian

Publisher: Wiley-VCH

Published: 1998

Total Pages: 568

ISBN-13:

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Rapid developments in biotechnology create a demand for practical, up-to-date reviews written by and for experts in industry. This compact handbook provides all relevant up-to-date information on important bioseparation and bioprocessing techniques that are actively applied in the biotechnology industries. The handbook presents an applications-orientated overview on - case studies and general strategies for quality control and characterization - detailed guidelines on developing economic and technically feasible bioseparation schemes - strategies and methods for intracellular bioproduct release - chromatographic and membrane downstream processes used in biotechnology - applications of modern non-invasive methods such as neural networks for on-line estimation and control of fermentation variables on an industrial scale - a practical, commercially-relevant guide to biosafety and many more aspects which are indispensible for present and future industrial success.