Fundamentals of Inflammation
Fundamentals of Inflammation

Author: Charles N. Serhan

Publisher: Cambridge University Press

Published: 2010-04-26

Total Pages: 489

ISBN-13: 1139936670

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The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.

Chemokines and Skin
Chemokines and Skin

Author: Eckhard Kownatzki

Publisher: Nelson Thornes

Published: 1998

Total Pages: 160

ISBN-13: 9783764358181

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Chemokines: Attraction of dendritic cells and role in tumor immunobiology.- Chemokine receptors.- Regulation of gene expression of chemokines and their receptors.- Chemokines and T lymphocytes.- Chemokines and mast cells.- Chemokines and eosinophils.- CXC-chemokines - autocrine growth factors for melanoma and epidermoid carcinoma cells.- Expression of chemokines in dermatoses.

Chemokine Receptors as Drug Targets
Chemokine Receptors as Drug Targets

Author: Martine J. Smit

Publisher: John Wiley & Sons

Published: 2010-12-07

Total Pages: 598

ISBN-13: 3527632344

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Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities. Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.

Chemokines in Disease
Chemokines in Disease

Author: Caroline A. Hébert

Publisher: Springer Science & Business Media

Published: 1999-06-01

Total Pages: 337

ISBN-13: 1592597068

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Caroline Hébert and a panel of key experimentalists and clinical investigators comprehensively review the state-of-the-art in the chemokine field, ranging from the effects of chemokines and their receptors in retroviral infections, to their role in inflammation, angiogenesis/angiostasis, and tumor cell biology. The book examines in detail fifteen recently identified chemokines and elucidates the role of chemokine function in vivo from animal experiments. Animal models are also used to explore how chemokines operate in a variety of chronic and acute inflammatory diseases and in noninflammatory processes. A detailed review of the emerging role of chemokines in viral biology is also presented, with emphasis on HIV biology and novel therapeutic possibilities. Chemokines in Disease: Biology and Clinical Research summarizes the rapidly expanding knowledge of a dazzling array of chemokines and provides fresh insights into the development of powerful new drugs for treating a wide spectrum of diseases.

Chemokines, Chemokine Receptors and Disease
Chemokines, Chemokine Receptors and Disease

Author: Lisa M. Schwiebert

Publisher: Gulf Professional Publishing

Published: 2005-09-02

Total Pages: 418

ISBN-13: 9780121533557

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This volume in the Current Topics in Membranes series discusses the biology of chemokines and their binding partners, chemokine receptors, in normal and disease-related states. Chemokines are small proteins that are important in normal immune responses. Recent research demonstrates a role for these proteins in a variety of diseases such as heart disease, allergy, asthma, and cancer. As a result of the discovery of this link to disease, the topic of chemokines and drugs that block their actions has become an intense are of study. This book presents the topics of chemokines, chemokine receptors, and related pathologies in an integrated manner that provides the reader with a comprehensive and up-to-date knowledge of these topics. Provides a comprehensive overview of the history, molecular biology, cell biology, pharmacology, physiology, and pathophysiology of chemokines and their receptors Each chapter discusses "future directions and unanswered questions" of chemokine biology Serves as a road map for future research

Chemokines in Viral Infections
Chemokines in Viral Infections

Author: Surendran Mahalingam

Publisher: Springer Science & Business Media

Published: 2004-10-14

Total Pages: 140

ISBN-13: 9780306482342

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In the past five years, a large number of new chemokines and chemokine receptors have been identified. Alarming progress in the areas of bioinformatics and expressed sequence tag (EST) databases attributed to this development. Recent discoveries provide compelling evidences supporting the roles of these messengers and their receptors in the control of viral infection as well as in aiding virus survival. Chemokines in Viral Infections is the first to provide a comprehensive write up on the various evidences available to date on the interactions between host chemokine system and viral chemokines. This book intends to unravel the chemokine constellation in the context of viral infections, a versatility that was not fully understood five years ago. This book is excellent reading material and will be of interest to research scientists, clinicians and postgraduate students.

Chemokines and Cancer
Chemokines and Cancer

Author: Barrett Rollins

Publisher: Springer Science & Business Media

Published: 1999-04-09

Total Pages: 314

ISBN-13: 1592597017

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Chemokines and Cancer synthesizes a state-of-the-art understanding of the role that chemokines and their receptors play in the pathophysiology of malignancy. It examines the influence of chemokines on a broad array of malignant cells, including their effects on such intrinsic properties as growth and movement, as well as exploring their influence on the host's response to a growing tumor. The authors also demonstrate the physiological consequences of chemokine expression and suggest how chemokines can be used to regulate tumor growth in vivo, including their direct effects on tumor growth, on tumor destruction by host inflammatory cells, and on tumor angiogenesis. The only book available that relates chemokines to cancer, Chemokines and Cancer holds out the promise of novel therapeutic approaches to malignancy through the manipulation of chemokines and/or their receptors.

Cytokines and Chemokines in Infectious Diseases Handbook
Cytokines and Chemokines in Infectious Diseases Handbook

Author: Malak Kotb

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 425

ISBN-13: 1592593097

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A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.