Challenges and Channels
Challenges and Channels

Author: Ikram Ahmed Ibrahim Elsherif

Publisher: Cambridge Scholars Publishing

Published: 2016-06-22

Total Pages: 190

ISBN-13: 1443895466

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This book deals with the “challenges of teaching the English language and literature” in the Middle East and North Africa region, with a special focus on the Gulf countries. It consists of different articles by an international group of educators and scholars who have first-hand experience in teaching the English language and its literatures in this region. The contributors not only investigate student attitudes, cultural, political and administrative obstacles and challenges, but they also embark upon soul-searching journeys in which they examine their own attitudes, teaching strategies, cultural prejudices and preconceptions, and personal responses to their teaching environments. They also explore, from their own personal experiences, the ‘crisis in the humanities’, cultural hegemony, ethics in translation, cross-cultural encounters, pedagogical challenges, textuality, and second language acquisition, among other issues and concerns. As such, the book represents both a scholarly investigation and a colorful palette of personal experience and response to human encounters in the classroom.

Targeting Ion Channels for Drug Discovery: Emerging Challenges for High Throughput Screening Technologies
Targeting Ion Channels for Drug Discovery: Emerging Challenges for High Throughput Screening Technologies

Author: Ciria Hernandez

Publisher: Frontiers Media SA

Published: 2024-06-07

Total Pages: 153

ISBN-13: 2832550169

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Ligand and voltage-gated ion channels are highly regulated protein molecules that cross the cell membrane allowing ion flow from one side of the membrane to the other. They are ubiquitously expressed in human tissues and consist of one of the largest and best understood functional groups of proteins, with more than 400 members spanning nearly 1% of the human genome. They are involved in a variety of fundamental physiological processes, and their malfunction causes numerous diseases. In terms of the challenges faced in the effort to discover specific drugs in ancient and emerging diseases, ion channels are the third-largest class of target proteins after G-protein-coupled receptors (GPCRs) and kinases. 15% of small molecule drug targets have been reported to be voltage- or ligand-gated ion channels, resulting in approximately 150 new drug candidates in preclinical and clinical studies. Of the ion channel targeting drugs found on the market, these were identified more than a decade ago, and many of the current studies are at various stages of scientific approval. Overcoming these challenges has led the field of ion channel drug discovery to transform over the past 15 years through major advancements in genetic target detection, validation, structure-based drug design, and drug modeling of cell-based diseases.

Real-Time Phoenix
Real-Time Phoenix

Author: Stephen Bussey

Publisher: Pragmatic Bookshelf

Published: 2020-03-25

Total Pages: 422

ISBN-13: 1680507753

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Give users the real-time experience they expect, by using Elixir and Phoenix Channels to build applications that instantly react to changes and reflect the application's true state. Learn how Elixir and Phoenix make it easy and enjoyable to create real-time applications that scale to a large number of users. Apply system design and development best practices to create applications that are easy to maintain. Gain confidence by learning how to break your applications before your users do. Deploy applications with minimized resource use and maximized performance. Real-time applications come with real challenges - persistent connections, multi-server deployment, and strict performance requirements are just a few. Don't try to solve these challenges by yourself - use a framework that handles them for you. Elixir and Phoenix Channels provide a solid foundation on which to build stable and scalable real-time applications. Build applications that thrive for years to come with the best-practices found in this book. Understand the magic of real-time communication by inspecting the WebSocket protocol in action. Avoid performance pitfalls early in the development lifecycle with a catalog of common problems and their solutions. Leverage GenStage to build a data pipeline that improves scalability. Break your application before your users do and confidently deploy them. Build a real-world project using solid application design and testing practices that help make future changes a breeze. Create distributed apps that can scale to many users with tools like Phoenix Tracker. Deploy and monitor your application with confidence and reduce outages. Deliver an exceptional real-time experience to your users, with easy maintenance, reduced operational costs, and maximized performance, using Elixir and Phoenix Channels. What You Need: You'll need Elixir 1.9+ and Erlang/OTP 22+ installed on a Mac OS X, Linux, or Windows machine.

Changing Minds or Changing Channels?
Changing Minds or Changing Channels?

Author: Kevin Arceneaux

Publisher: University of Chicago Press

Published: 2013-08-27

Total Pages: 255

ISBN-13: 022604744X

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We live in an age of media saturation, where with a few clicks of the remote—or mouse—we can tune in to programming where the facts fit our ideological predispositions. But what are the political consequences of this vast landscape of media choice? Partisan news has been roundly castigated for reinforcing prior beliefs and contributing to the highly polarized political environment we have today, but there is little evidence to support this claim, and much of what we know about the impact of news media come from studies that were conducted at a time when viewers chose from among six channels rather than scores. Through a series of innovative experiments, Kevin Arceneaux and Martin Johnson show that such criticism is unfounded. Americans who watch cable news are already polarized, and their exposure to partisan programming of their choice has little influence on their political positions. In fact, the opposite is true: viewers become more polarized when forced to watch programming that opposes their beliefs. A much more troubling consequence of the ever-expanding media environment, the authors show, is that it has allowed people to tune out the news: the four top-rated partisan news programs draw a mere three percent of the total number of people watching television. Overturning much of the conventional wisdom, Changing Minds or Changing Channels? demonstrate that the strong effects of media exposure found in past research are simply not applicable in today’s more saturated media landscape.

Discovery Channel Young Scientist Challenge
Discovery Channel Young Scientist Challenge

Author: Rosanna Hansen

Publisher: John Wiley & Sons

Published: 2006-10-27

Total Pages: 54

ISBN-13: 0787984930

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Science projects have never been so exciting! Every year, 6,000 middle schoolstudents are nominated for the Discovery Channel Young Scientist Challenge, the only competition of its kind for students in grades 5 to 8. Of those 6,000 students, 40 finalists are chosen and brought to Washington, D.C., for a week of intense science "challenges" in various science disciplines. The challenges are televised on the Discovery Channel, and the winning teams and individuals are presented with science awards and prizes. This book follows some of the students selected for the Discovery Channel Young Scientist Challenge and includes colorful descriptions of how the teams solved the challenges, inspiring profiles of the winners, tips on preparing science projects, and dozens of winning project ideas that kids can use to inspire their own awesome science projects! Taking Science to the Extreme! shows kids how they can be part of the Discovery Channel Young Scientist Challenge and learn to think and have fun like a real scientist. Rosanna Hansen is the author of many books for children and young adults and a former publisher at Troll and Reader’s Digest.

Fully Awake 365: 365 Days That Will Challenge Your Mind, Channel Your Power and Change Your Life
Fully Awake 365: 365 Days That Will Challenge Your Mind, Channel Your Power and Change Your Life

Author: D.E. Paulk

Publisher: Spirit and Truth Sanctuary

Published: 2023-01-01

Total Pages: 477

ISBN-13: 1737045176

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You are about to embark on 365 days of a transformational journey that will radically shift your consciousness, awaken your creative capacity and summon your God-given power. Here is the beauty of vibration: D.E. & LaDonna think so much alike that we challenge you to see if you can decipher which one of them wrote which devotionals. These 365 Affirmations will Challenge Your Mind, Channel Your Power and Change Your Life. Each affirmation, teaching and affirmative prayer is designed to purposefully turn you within so you can powerfully create without. I am honored you would join us on the journey of becoming Fully Awake.

Virtual Reality
Virtual Reality

Author: National Research Council

Publisher: National Academies Press

Published: 1995-01-13

Total Pages: 557

ISBN-13: 0309051355

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Despite widespread interest in virtual reality, research and development efforts in synthetic environments (SE)â€"the field encompassing virtual environments, teleoperation, and hybridsâ€"have remained fragmented. Virtual Reality is the first integrated treatment of the topic, presenting current knowledge along with thought-provoking vignettes about a future where SE is commonplace. This volume discusses all aspects of creating a system that will allow human operators to see, hear, smell, taste, move about, give commands, respond to conditions, and manipulate objects effectively in a real or virtual environment. The committee of computer scientists, engineers, and psychologists on the leading edge of SE development explores the potential applications of SE in the areas of manufacturing, medicine, education, training, scientific visualization, and teleoperation in hazardous environments. The committee also offers recommendations for development of improved SE technology, needed studies of human behavior and evaluation of SE systems, and government policy and infrastructure.

Ion Channels
Ion Channels

Author: James N. C. Kew

Publisher:

Published: 2010

Total Pages: 586

ISBN-13: 0199296758

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Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.

Feasibility Studies: New Product Development and Launch
Feasibility Studies: New Product Development and Launch

Author: Abisha Kampira

Publisher: Afregarde Strategies

Published: 2023-02-21

Total Pages: 53

ISBN-13:

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This book was prepared as a general guide to feasibility studies for the development and launch of new products. These products could be new to a company or new to a particular market. The document was prepared for management and operational teams that are involved in feasibility analysis. It assumes that the targeted document users are familiar with basic and intermediary strategic management tools.