Cephalosporins and Penicillins
Cephalosporins and Penicillins

Author: Edwin H. Flynn

Publisher: Elsevier

Published: 2013-10-22

Total Pages: 769

ISBN-13: 1483270173

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Cephalosporins and Penicillins: Chemistry and Biology describes the studies made on cephalosporin in relation to the scientific and medicinal benefits that can be derived from cephalosporin C. This collection discusses how cephalosporin C is produced through modern isolation methods. One paper discusses its structure through chemical means, its degradation products, its derivative and other metabolic products such as penicillin N and cephalosporin P. Another paper explains the preparation method for 7-aminocephalosporanic acid and 6-aminopenicillanic acid through biological or chemical means. Another paper explains the alteration of the dihydrothiazine ring of the cephalosporins as the functionalities of these rings are chemically difficult to obtain. One paper also explains the rearrangements of cephalosporins and penicillins; cephalosporin can be synthesized from penicillin through an intermediacy of penicillin sulfoxide. Other papers discuss the pharmacology and toxicology of cephalosporins, as well as the practical tests and methods of assay that can be used in most cephalosporins, and in some cases, in penicillins. This book can prove useful for pharmacologists, microchemists, research workers, and technologists dealing with toxicology.

Drug-Induced Liver Injury
Drug-Induced Liver Injury

Author:

Publisher: Academic Press

Published: 2019-07-13

Total Pages: 290

ISBN-13: 0128173173

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Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Oral Cephalosporins
Oral Cephalosporins

Author: Robert C. Moellering

Publisher: S Karger Ag

Published: 1995

Total Pages: 0

ISBN-13: 9783805561631

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This volume provides an excellent survey of the chemistry, microbiology, pharmacology and clinical use of the oral cephalosporins in general and the newer agents in particular. The cephalosporins have long provided satisfactory treatment for many disorders without causing serious side effects; and over the past fifty years forms with different antimicrobial, pharmacologic and toxicologic properties have been developed. Despite the broad spectrum of their activity against a large variety of gram-positive and gram-negative bacteria, the third-generation oral cephalosporins including the prodrug esters do not work against Pseudomonas aeruginosa, methicillin-resistant staphylococci, enterococci or Bacteroides species. Many, however, are suitable for treating infections of the respiratory and urinary tracts and of the skin and its structure, as well as certain sexually-transmitted diseases. Authors consider other possible uses, against multi-resistant Enterobacteriaceae for instance, but also point out the limitations of the oral cephalosporins. For those working in the fields of infectious disease, bacteriology, chemotherapy, pharmaceutics and pharmacokinetics, this book is a valuable source of authoritative information.

Introduction to Basics of Pharmacology and Toxicology
Introduction to Basics of Pharmacology and Toxicology

Author: Abialbon Paul

Publisher: Springer Nature

Published: 2021-03-13

Total Pages: 1156

ISBN-13: 9813360097

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This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

Penicillins and Cephalosporins
Penicillins and Cephalosporins

Author: Robert B. Morin

Publisher: Academic Press

Published: 2014-05-10

Total Pages: 594

ISBN-13: 1483277194

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Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.

Hepatotoxicity
Hepatotoxicity

Author: Hyman J. Zimmerman

Publisher: Lippincott Williams & Wilkins

Published: 1999

Total Pages: 848

ISBN-13: 9780781719520

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Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Antibiotic Drug Resistance
Antibiotic Drug Resistance

Author: José-Luis Capelo-Martínez

Publisher: John Wiley & Sons

Published: 2019-09-24

Total Pages: 730

ISBN-13: 1119282527

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This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies

Clinical Infectious Diseases Study Guide
Clinical Infectious Diseases Study Guide

Author: Joseph Domachowske

Publisher: Springer Nature

Published: 2020-08-05

Total Pages: 357

ISBN-13: 3030508730

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This book is meticulously designed for the busy student, trainee, or seasoned physician looking to enhance or refresh skills in infectious diseases. It is intended to provide a solid resource for students and physicians in need of a concise yet comprehensive background of the material. Each chapter begins with a summary of the topic, a brief case description, definitions, critical teaching points, and tables, figures, photos, and other visual materials to reinforce learning. The chapters take a systems based approach to infections before concluding with the essentials of diagnostic microbiology to leave users with a practical toolkit for real-world clinics. Authored by two expert educators and dual infectious diseases and pediatrics specialists, Clinical Infectious Diseases Study Guide is the only updated study guide designed for medical students, fellows, residents, and trainees who need a strong foundation in infectious diseases. This includes infectious disease specialists in both adult and pediatric care, various internal medicine subspecialists, and hospitalists.

Drug Allergy Testing
Drug Allergy Testing

Author: David Khan

Publisher: Elsevier Health Sciences

Published: 2017-07-05

Total Pages: 289

ISBN-13: 0323497071

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With a focus on improving diagnosis and treatment, Drug Allergy Testing is your new go-to resource for understanding various drug allergies and testing methods, the epidemiology of and economic impact of drug allergies, and new drug and allergy developments. - Features a wealth of up-to-date information for allergists, immunologists, and primary care physicians who diagnose and treat patients with drug allergies and hypersensitivity. - Covers the basics of drug allergy evaluation and management as well as specific drugs including antibiotics, ASA/NSAIDs, chemotherapeutic agents and monoclonal antibodies.