Cell Apoptosis Research Trends
Cell Apoptosis Research Trends

Author:

Publisher: Nova Publishers

Published: 2007

Total Pages: 312

ISBN-13: 9781600214240

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Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer's disease and cancer. A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. This book presents exciting research in this related field.

Human Cytomegalovirus
Human Cytomegalovirus

Author: Thomas E. Shenk

Publisher: Springer Science & Business Media

Published: 2008-05-09

Total Pages: 477

ISBN-13: 3540773495

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This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.

Trends in Stem Cell Proliferation and Cancer Research
Trends in Stem Cell Proliferation and Cancer Research

Author: Rodrigo R. Resende

Publisher: Springer Science & Business Media

Published: 2013-08-13

Total Pages: 663

ISBN-13: 9400762119

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The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance

Apoptosis Methods and Protocols
Apoptosis Methods and Protocols

Author: Hugh J. M. Brady

Publisher: Springer Science & Business Media

Published: 2008-02-05

Total Pages: 306

ISBN-13: 1592598129

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The most fundamental question facing each and every cell within an org- ism is to survive or to die. Cell death is required for normal function; some estimates suggest that as many as one million cells undergo cell death every second in the adult human body. Almost all cells undergoing physiological, or programmed, cell death, independent of cell type, manifest a stereotypic p- tern of morphological changes termed apoptosis. Typically, apoptotic cells d- play shrinkage, membrane blebbing, chromatin condensation, and nuclear fragmentation. The integrity of the cell membrane is not lost during apoptosis and so avoids eliciting the inflammatory response that would have been caused by the spillage of the cell’s contents. This is quite in contrast to the loss of cell contents typical of necrosis. The caspases, the family of intracellular cysteine proteases associated with apoptosis, are responsible for the stereotypical m- phological changes. Caspases cleave various substrate proteins that act on DNA fragmentation, nuclear envelope integrity, the cytoskeleton, and cell volume regulation. Apoptotic cells are cleared in vivo by the process of phagocytosis, in which specific “phagocytes” move to the site of apoptosis, engulf the dying cells and digest them. Apoptosis has a central role in many physiological processes, for example, in the immune system. Autoreactive cells are deleted via apoptosis to prevent autoimmunity. At the end of an immune response, activated lymphocytes are removed to maintain homeostasis within the immune system.

Mechanisms of Cell Death
Mechanisms of Cell Death

Author: Zahra Zakeri

Publisher:

Published: 1999

Total Pages: 236

ISBN-13:

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Contains papers from a July 1998 conference held at the Queens College Campus of the City University of New York. Papers are arranged in sections on mechanisms and general considerations, programmed (developmental) cell death, and cell death and pathological and clinical situations. Specific topics

Self and Nonself
Self and Nonself

Author: Carlos López-Larrea

Publisher: Springer Science & Business Media

Published: 2012-03-07

Total Pages: 338

ISBN-13: 1461416809

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In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.

Sensory Hair Cell Death and Regeneration
Sensory Hair Cell Death and Regeneration

Author: Michael E. Smith

Publisher: Frontiers Media SA

Published: 2016-12-13

Total Pages: 268

ISBN-13: 2889450007

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Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as aging, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of these hair cells lead to deficits in hearing and balance, and in mammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells. Researchers have been examining the process of hair cell death and regeneration in animal models in an attempt to find ways of either preventing hair cell loss or stimulating the production of new hair cells in mammals, with the ultimate goal of finding new therapeutics for human sensorineural hearing and balance deficits. This has led to a wide array of research on sensory hair cells- such as understanding the factors that cause hair cell loss and finding agents that protect them from damage, elucidating the cell signaling pathways activated during hair cell death, examining the genes and cellular pathways that are regulated during the process of hair cell death and regeneration, and characterizing the functional sensory loss and recovery following acoustic or ototoxic insults to the inner ear. This research has involved cell and developmental biologists, physiologists, geneticists, bioinformaticians, and otolaryngologists. In this Research Topic, we have collated reviews of the past progress of hair cell death and regeneration studies and original research articles advancing sensory hair cell death and regeneration research into the future.

The Warburg Effect Regulation Under Siege: The Intertwined Pathways in Health and Disease
The Warburg Effect Regulation Under Siege: The Intertwined Pathways in Health and Disease

Author: Concetta Bubici

Publisher: Frontiers Media SA

Published: 2019-10-17

Total Pages: 128

ISBN-13: 2889630013

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Many cells, including immune, neuronal, cancer and stem cells, become dependent on aerobic glycolysis to escape apoptosis and accommodate their bioenergetics needs. How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where it was first observed with the aim of decoding the molecular networks controlling its activation for therapeutic purposes. This Research Topic aimed to discuss and review all the intracellular signaling regulating the Warburg effect in cancerous and normal non-cancerous cells though original research articles, mini reviews and reviews.