Surface and Interfacial Aspects of Cell Adhesion

Surface and Interfacial Aspects of Cell Adhesion

Author: Alain Carré

Publisher: CRC Press

Published: 2011-01-19

Total Pages: 545

ISBN-13: 9004190783

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Cell adhesion comes into play in almost all domains of life. The range of situations in which it occurs, involving organisms, living tissues, microorganisms or single cells, is endless. Cell adhesion is involved in the binding of a cell to a surface, extracellular matrix, or another cell using cell adhesion molecules. It is crucial in the formation and maintenance of coherent multicellular structures. Cell surface adhesion molecules (integrins, for example) which transmit information from the extracellular matrix to the cell play vital roles in numerous cellular processes. Some of these include: cell growth, differentiation, embryogenesis, immune cell transmigration and response, and cancer metastasis. Also cell adhesion is involved in most of pathological situations. This book is divided into four parts as follows: Part 1: Fundamentals of Cell Adhesion; Part 2: Methods to Study Cell Adhesion; Part 3: Surface Treatments to Control Cell Adhesion and Behavior; and Part 4: Cell Adhesion in Medicine and Therapy. A bountiful information is covered in this book which represents the cumulative wisdom of many world-renowned researchers( physicists, materials scientists, chemists and biologists) engaged in unraveling the mechanisms of cell adhesion and how to mitigate or control it. It quite patent from the topics covered in this book that the subject of cell adhesion is truly interdisciplinary. This book should be of great interest and value to anyone interested in cell adhesion which is vitally important to human life.


Inflammation and the Microcirculation

Inflammation and the Microcirculation

Author: D. Neil Granger

Publisher: Morgan & Claypool Publishers

Published: 2010

Total Pages: 99

ISBN-13: 1615041656

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The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References


Bacterial Adhesion to Cells and Tissues

Bacterial Adhesion to Cells and Tissues

Author: Itzhak Ofek

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 585

ISBN-13: 1468464353

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Attachment to host cells or tissues is often the first step in the establishment of bacterial infections. A complex array of recognition, attachment, and virulence factors is involved in this process, which recent research has greatly illuminated. This comprehensive and authoritative volume discusses the specific cell and tissue-specific affinities of pathogenic microorganisms, including bioinorganic surfaces such as teeth, and is an essential reference for researchers and students of host-pathogen interactions.


Signaling Through Cell Adhesion Molecules

Signaling Through Cell Adhesion Molecules

Author: Jun-Lin Guan

Publisher: CRC Press

Published: 2019-04-30

Total Pages: 396

ISBN-13: 9781420049435

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The field of signal transduction research is one of the fastest growing in all of biomedical research in recent years. Signaling through cell adhesion molecules have long been of interest because of their importance in embryonic development, homeostasis, immune responses, wound healing , and malignant transformation. However, it is only recently re


Cell Adhesion Molecules

Cell Adhesion Molecules

Author: Vladimir Berezin

Publisher: Springer Science & Business Media

Published: 2013-11-18

Total Pages: 424

ISBN-13: 1461480906

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Cell Adhesion Molecules: Implications in Neurological Diseases contains review articles on recent developments in the field of neural cell adhesion molecules (CAMs). The main focus is on the role of cell adhesion molecules in various neurological and neurodegenerative diseases. This perspective has been essentially overlooked in recently published books on neural CAMs. In addition, the contributors cover many newly identified cell adhesion molecules and some that have not received much attention in recent years. This books fills an important gap in the currently available literature. ​


Cell Adhesion and Migration in the Development of Multicellular Organisms

Cell Adhesion and Migration in the Development of Multicellular Organisms

Author: Takaaki Matsui

Publisher: Frontiers Media SA

Published: 2019-01-24

Total Pages: 122

ISBN-13: 2889456943

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During development, cells are generated at specific locations within the embryo and then migrate into their destinations. At their destinations, they assemble together through cell adhesions, eventually leading to the formation of tissues and organs. In some cases, orchestration of cell adhesion and migration produces the global movement of cell groups, called collective cell migration, which is also required for the development of basic tissue structures such as spheres, clusters, and vesicles in the morphogenetic processes of development. Therefore, individual regulation and orchestration of cell adhesion and migration are quite important for appropriate tissue/organ formation during development. However, how cell adhesion and migration are regulated, and orchestrated during development? How cell adhesion and migration affects tissue formation during development? To answer these questions, we assembled several review and research articles in this eBook. By assembling these articles, we could explore the presence of core regulatory mechanisms and deepen the current understanding of cell adhesion and migration during the development of multicellular organisms.


Cell Adhesion in Bioprocessing and Biotechnology

Cell Adhesion in Bioprocessing and Biotechnology

Author: Martin Hjortso

Publisher: CRC Press

Published: 1994-10-20

Total Pages: 300

ISBN-13: 9780824789459

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Offers a detailed introduction to the fundamental phenomena that govern cell adhesion and describes bioengineering processes that employ cell adhesion, focusing on both biochemical and biomedical applications. All industrially relevant issues of cell adhesion - from basic concepts, quantitative experiments, and mathematical models to applications in bioreactors and other process equipment - are examined.


Physics of Bio-Molecules and Cells

Physics of Bio-Molecules and Cells

Author: Henrik Flyvbjerg

Publisher: Springer Science & Business Media

Published: 2003-07-01

Total Pages: 591

ISBN-13: 3540457011

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Aimed at those working to enter this rapidly developing field, this volume on biological physics is written in a pedagogical style by leading scientists giving explanations that take their starting point where any physicist can follow and end at the frontier of research in biological physics. These lectures describe the state-of-the-art physics of biomolecules and cells. In biological systems ranging from single biomolecules to entire cells and larger biological systems, it focuses on aspects that require concepts and methods from physics for their analysis and understanding, such as the mechanics of motor proteins; how the genetic code is physically read and managed; the machinery of protein--DNA interactions; force spectroscopy of biomolecules' velopes, cytoskeletons, and cytoplasms; polymerization forces; listeria propulsion; cell motility; lab-on-a-chip nanotechnology for single-molecule analysis of biomolecules; bioinformatics; and coding and computational strategies of the brain.


Cells: Molecules and Mechanisms

Cells: Molecules and Mechanisms

Author: Eric Wong

Publisher: Axolotl Academic Publishing

Published: 2009

Total Pages: 283

ISBN-13: 0985226110

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"Yet another cell and molecular biology book? At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? First, it's a course that I have enjoyed teaching for many years, so I am very familiar with what a student really needs to take away from this class within the time constraints of a semester. Second, because it is a course that many students take, there is a greater opportunity to make an impact on more students' pocketbooks than if I were to start off writing a book for a highly specialized upper- level course. And finally, it was fun to research and write, and can be revised easily for inclusion as part of our next textbook, High School Biology."--Open Textbook Library.