Cartilage Tissue Engineering and Regeneration Techniques
Cartilage Tissue Engineering and Regeneration Techniques

Author: Dimitrios D. Nikolopoulos

Publisher: BoD – Books on Demand

Published: 2019-06-05

Total Pages: 160

ISBN-13: 1789238498

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Osteochondral defects can be challenging to treat, first, because the damaged articular cartilage has a poor intrinsic reparative capability, and second, because these defects cause chronic pain and serious disability. That is why cartilage repair remains one of the most challenging issues of musculoskeletal medicine. Arthroscopic and open techniques that have been developed over the last two decades intend to promote the success of complete repair of the articular cartilage defects; nevertheless, these therapies cannot always offer 100% success. Nowadays, cartilage tissue engineering is an emerging technique for the regeneration of cartilage tissue. Taking into consideration these perspectives, this book aims to present a summary of cartilage tissue engineering, including development, recent progress, and major steps taken toward the regeneration of functional cartilage tissue. Special emphasis is placed on the role of stimulating factors, including growth factors, gene therapies, as well as scaffolds, including natural, synthetic, and nanostructured.

Cartilage Tissue Engineering and Regeneration Techniques
Cartilage Tissue Engineering and Regeneration Techniques

Author: Kalpaxis Dimitrios

Publisher:

Published: 2019

Total Pages: 158

ISBN-13: 9781789238501

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Osteochondral defects can be challenging to treat, first, because the damaged articular cartilage has a poor intrinsic reparative capability, and second, because these defects cause chronic pain and serious disability. That is why cartilage repair remains one of the most challenging issues of musculoskeletal medicine. Arthroscopic and open techniques that have been developed over the last two decades intend to promote the success of complete repair of the articular cartilage defects; nevertheless, these therapies cannot always offer 100% success. Nowadays, cartilage tissue engineering is an emerging technique for the regeneration of cartilage tissue. Taking into consideration these perspectives, this book aims to present a summary of cartilage tissue engineering, including development, recent progress, and major steps taken toward the regeneration of functional cartilage tissue. Special emphasis is placed on the role of stimulating factors, including growth factors, gene therapies, as well as scaffolds, including natural, synthetic, and nanostructured.

Cartilage Tissue Engineering
Cartilage Tissue Engineering

Author: Martin J. Stoddart

Publisher: Springer Nature

Published: 2022-11-10

Total Pages: 392

ISBN-13: 1071628399

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This detailed book brings together a collection of methodologies, from the most basic to the more complex, that provides researchers with a platform they can use to embark on a cartilage research career. To aid in the search for novel therapies for cartilage regeneration, this volume addresses 3D cartilage models, challenges associated with RNA and protein extraction, imaging, gene transfer, as well as stable differentiation and variations in cell phenotype from different tissue origins. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Cartilage Tissue Engineering serves as an ideal guide for researchers working to advance the vital study of cartilage biology and repair.

Tissue Engineering of Cartilage and Bone
Tissue Engineering of Cartilage and Bone

Author: Gregory R. Bock

Publisher: John Wiley & Sons

Published: 2003-07-22

Total Pages: 262

ISBN-13: 0470864230

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Tissue engineering takes advantages of the combined use of cultured living cells and three-dimensional scaffolds to reconstruct adult tissues that are absent or malfunctioning. This book brings together scientists and clinicians working on a variety of approaches for regenerating of damaged or lost cartilage and bone to assess the progress of this dynamic field. In its early days, tissue engineering was driven by material scientists who designed novel bio-resorbable scaffolds on which to seed cells and grow tissues. This ground-breaking work generated high expectations, but there have been significant stumbling blocks holding back the widespread use of these techniques in the clinic. These challenges, and potential ways of overcoming them, are given thorough coverage in the discussions that follow each chapter. The key questions addressed in this book include the following. How good must cartilage repair be for it to be worthwhile? What is the best source of cells for tissue engineering of both bone and cartilage? Which are the most effective cell scaffolds? What are the best preclinical models for these technologies? And when it comes to clinical trials, what sort of outcome measures should be used? With contributions from some of the leading experts in this field, this timely publication will prove essential reading for anyone with an interest in the field of tissue engineering.

Cartilage: From Biology to Biofabrication
Cartilage: From Biology to Biofabrication

Author: Mohamadreza Baghaban Eslaminejad

Publisher: Springer Nature

Published: 2023-07-11

Total Pages: 531

ISBN-13: 9819924529

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This book provides a comprehensive overview of cartilage structure, functions, and approaches for the regeneration of cartilage tissue. It reviews multiple signaling pathways that are involved in the growth and repair of cartilage tissue. The initial chapter of the book examines the etiology, diagnosis, and pathological features of various cartilage diseases. Subsequently, the book presents recent advances in biomaterial sciences, regenerative medicine, and fabrication technology for cartilage regeneration. It discusses hydrogels as a promising scaffold for cartilage tissue engineering, focusing on recapitulating microenvironments present during development or in adult tissue to induce the formation of cartilaginous constructs with biochemical and mechanical properties of native tissue. Lastly, it covers the applications of 3 D printing techniques for the fabrication of scaffolds for cartilage tissue regeneration for the production of biological implants capable of treating a range of conditions.

A Tissue Regeneration Approach to Bone and Cartilage Repair
A Tissue Regeneration Approach to Bone and Cartilage Repair

Author: Hala Zreiqat

Publisher: Springer

Published: 2014-12-05

Total Pages: 257

ISBN-13: 3319132660

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Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration. Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues. This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.

Cartilage Regeneration
Cartilage Regeneration

Author: Yunfeng Lin

Publisher: Humana Press

Published: 2017-02-21

Total Pages: 98

ISBN-13: 3319516175

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This book focuses on cartilage defects and new mesenchymal stem cell-based treatments for their repair and regeneration. Early chapters provide a review of current etiological findings and repair methods of cartilage defects. The next chapters discuss fundamental concepts and features of MSCs, including their proliferation, differentiation, migration and immunomodulatory effects. The discussion also includes clinical applications of MSCs in cartilage tissues, especially with regards to various animal models, biomaterials and transferring techniques. Cartilage Regeneration focuses on the biology of MSCs and their possible applications in cartilage reconstruction, with the goal of bringing new insights into regenerative medicine. It will be essential reading for researchers and clinicians in stem cells, regenerative medicine, biomedical engineering and orthopedic surgery.

Cartilage Repair and Regeneration
Cartilage Repair and Regeneration

Author: Alessandro Rozim Zorzi

Publisher: BoD – Books on Demand

Published: 2018-02-14

Total Pages: 230

ISBN-13: 9535137883

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This work is the result of a partnership that began in 2011, when I received for the first time the invitation to be the scientific editor of a book on bone grafting, by the still little publisher known as InTech. Now six years later, InTech has grown and thrived. My respect and warm approval for the quality of the publisher's work only increased. The hyaline cartilage is a tissue that challenges tissue engineering and regenerative medicine because of its avascular nature. In the 11 chapters of this book, the reader will find texts written by researchers working on advanced topics related to basic laboratory research, as well as excellent reviews on the clinical use of currently available therapies.

Techniques in Cartilage Repair Surgery
Techniques in Cartilage Repair Surgery

Author: A. Ananthram Shetty

Publisher: Springer Science & Business Media

Published: 2014-04-11

Total Pages: 379

ISBN-13: 3642419216

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Cartilage defects are common. Cartilage repair surgery is not only fascinating but also surgically challenging. There are books dealing with basic science and some surgical aspect. This book fills a gap in surgical techniques for cartilage repair. All of the surgical chapters are logically organised, covering patient selection, patient setup/positioning, surgical approach, potential complications and troubleshooting. An attempt is made to compare with various surgical techniques. This book also covers anaesthesia, postoperative follow-up, pain management and rehabilitation. Both the editors and the authors are renowned experts in the field. This book will be invaluable for orthopaedic and sports medicine surgeons (consultants and training doctors) and is also of potential interest to physiotherapists, medical students, general practitioners, physical medicine and rehabilitation specialists and rheumatology specialists.

Articular Cartilage Tissue Engineering
Articular Cartilage Tissue Engineering

Author: Kyriacos Athanasiou

Publisher: Springer Nature

Published: 2022-06-01

Total Pages: 174

ISBN-13: 3031025784

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Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions