A review of recent research on strategies and applications of the C-13 chemical shift, a method for determining configuration of organic compounds. Introduces C-13 NMR spectroscopy, and describes conditions for collecting the FID, for data handling, and for obtaining a well- resolved C-13 NMR spectrum, as well as various substituent effect correlations, their derivations, and the origin of the effects. Also discusses the use of multidimensional NMR methods. For organic, physical, and natural products chemists. Includes bandw diagrams. Annotation copyright by Book News, Inc., Portland, OR
Through numerous conversations with other synthetic chemists it became apparent that the great power of carbon nuclear magnetic resonance was being significantly underutilized. In our own work we have found that 13C spectroscopy is a more powerful tool than IH NMR spectroscopy, especially for probing subtle stereochemical questions in complicated systems. This is especially true in five membered ring compounds where IH NMR is at a particular disadvantage. The two techniques can be used independently to solve the same question-that of stereochemistry - but they do so in different ways. Advantage can be taken in IH NMR of a relatively consistent relationship between stereochemical orientation and coupling constants between vicinal protons, while in 13C NMR it is the correlation between spatial relationships of non-hydrogen, y substituents and their effect on chemical shift that can be used to assign stereochemistry. It was also clear that the use of 13C NMR required a different approach to problem solving than that typically used with IH NMR. While the latter technique could be employed with a very general approach (e.g., the Karplus equation), 13C NMR would, at least for the immediate future, require a relatively extensive set of model systems from which the consequences of stereochemical changes could be derived for any given carbon framework.
Researchers in chemistry, chemical engineering, pharmaceutical science, forensics, and environmental science make routine use of chemical analysis, but the information these researchers need is often scattered in different sources and difficult to access. The CRC Handbook of Basic Tables for Chemical Analysis: Data-Driven Methods and Interpretation, Fourth Edition is a one-stop reference that presents updated data in a handy format specifically designed for use when reaching a decision point in designing an analysis or interpreting results. This new edition offers expanded coverage of calibration and uncertainty, and continues to include the critical information scientists rely on to perform accurate analysis. Enhancements to the Fourth Edition: Compiles a huge array of useful and important data into a single, convenient source Explanatory text provides context for data and guidelines on applications Coalesces information from several different fields Provides information on the most useful "wet" chemistry methods as well as instrumental techniques, with an expanded discussion of laboratory safety Contains information of historical importance necessary to interpret the literature and understand current methodology. Unmatched in its coverage of the range of information scientists need in the lab, this resource will be referred to again and again by practitioners who need quick, easy access to the data that forms the basis for experimentation and analysis.
Through numerous conversations with other synthetic chemists it became apparent that the great power of carbon nuclear magnetic resonance was being significantly underutilized. In our own work we have found that 13C spectroscopy is a more powerful tool than IH NMR spectroscopy, especially for probing subtle stereochemical questions in complicated systems. This is especially true in five membered ring compounds where IH NMR is at a particular disadvantage. The two techniques can be used independently to solve the same question-that of stereochemistry - but they do so in different ways. Advantage can be taken in IH NMR of a relatively consistent relationship between stereochemical orientation and coupling constants between vicinal protons, while in 13C NMR it is the correlation between spatial relationships of non-hydrogen, y substituents and their effect on chemical shift that can be used to assign stereochemistry. It was also clear that the use of 13C NMR required a different approach to problem solving than that typically used with IH NMR. While the latter technique could be employed with a very general approach (e.g., the Karplus equation), 13C NMR would, at least for the immediate future, require a relatively extensive set of model systems from which the consequences of stereochemical changes could be derived for any given carbon framework.
The second volume of NMR Spectroscopy in the Undergraduate Curriculum continues the work started in the first volume in providing effective approaches for using nuclear magnetic resonance spectrometers as powerful tools for investigating a wide variety of phenomena at the undergraduate level. This volume focuses on first year and organic chemistry courses. The applications and strategies in this volume will be helpful to those who are looking to transform their curriculum by integrating more NMR spectroscopy, to those who might not have considered NMR spectroscopy as a tool for solving certain types of problems, or for those seeking funding for a new or replacement NMR spectrometer.
From forensics and security to pharmaceuticals and environmental applications, spectroscopic detection is one of the most cost-effective methods for identifying chemical compounds in a wide range of disciplines. For spectroscopic information, correlation charts are far more easily used than tables, especially for scientists and students whose own a
Unter Zirkulardichroismus (CD) versteht man die spezifisch unterschiedliche Absorption von links- und rechtszirkular polarisiertem Licht durch bestimmte Moleküle. CD-Effekte lassen sich in Abhängigkeit von der Wellenlänge messen und spektroskopisch auswerten; sie geben beispielsweise Auskunft über die Konformation organischer Verbindungen. Dieses Buch richtet sich an den organischen Chemiker, der mit den Grundprinzipien der Stereochemie vertraut ist, und erläutert die Anwendung der CD-Spektroskopie zur Konformationsanalyse ausführlich und verständlich. (06/00)
Anhand verschiedener Beispiele zeigen die Autoren die Bedeutung der Kristallographie für Chemie und Biochemie auf und bieten somit eine gute Zusammenfassung der allgemeinen Prinzipien der Kristallstrukturanalyse. Zum einen sollen Interessierte, die diese Methode nicht selbst durchführen, in die Lage versetzt werden, deren Ergebnisse zu interpretieren. Zum anderen wird dem Leser deutlich gemacht, welche Bedeutung die ungeheure Datenmenge, die sich aus dieser Methode ergibt, einerseits für die Chemie sowie andererseits für die Biochemie hat. Das Buch ist verständlich geschrieben und mit zahlreichen Abbildungen versehen. Durch die Darstellung der Kristallstrukturanalyse im Vergleich zu anderen Methoden ist das Werk auch besonders für fortgeschrittene Studenten geeignet, die sich mit der Kristallographie vertraut machen wollen.
Mirroring the growth and direction of science for a century, the Handbook, now in its 93rd edition, continues to be the most accessed and respected scientific reference in the world. An authoritative resource consisting tables of data, its usefulness spans every discipline. This edition includes 17 new tables in the Analytical Chemistry section, a major update of the CODATA Recommended Values of the Fundamental Physical Constants and updates to many other tables. The book puts physical formulas and mathematical tables used in labs every day within easy reach. The 93rd edition is the first edition to be available as an eBook.
Celebrating the 100th anniversary of the CRC Handbook of Chemistry and Physics, this 94th edition is an update of a classic reference, mirroring the growth and direction of science for a century. The Handbook continues to be the most accessed and respected scientific reference in the science, technical, and medical communities. An authoritative resource consisting of tables of data, its usefulness spans every discipline. Originally a 116-page pocket-sized book, known as the Rubber Handbook, the CRC Handbook of Chemistry and Physics comprises 2,600 pages of critically evaluated data. An essential resource for scientists around the world, the Handbook is now available in print, eBook, and online formats. New tables: Section 7: Biochemistry Properties of Fatty Acid Methyl and Ethyl Esters Related to Biofuels Section 8: Analytical Chemistry Gas Chromatographic Retention Indices Detectors for Liquid Chromatography Organic Analytical Reagents for the Determination of Inorganic Ions Section 12: Properties of Solids Properties of Selected Materials at Cryogenic Temperatures Significantly updated and expanded tables: Section 3: Physical Constants of Organic Compounds Expansion of Diamagnetic Susceptibility of Selected Organic Compounds Section 5: Thermochemistry, Electrochemistry, and Solution Chemistry Update of Electrochemical Series Section 6: Fluid Properties Expansion of Thermophysical Properties of Selected Fluids at Saturation Major expansion and update of Viscosity of Liquid Metals Section 7: Biochemistry Update of Properties of Fatty Acids and Their Methyl Esters Section 8: Analytical Chemistry Major expansion of Abbreviations and Symbols Used in Analytical Chemistry Section 9: Molecular Structure and Spectroscopy Update of Bond Dissociation Energies Section 11: Nuclear and Particle Physics Update of Summary Tables of Particle Properties Section 14: Geophysics, Astronomy, and Acoustics Update of Atmospheric Concentration of Carbon Dioxide, 1958-2012 Update of Global Temperature Trend, 1880-2012 Major update of Speed of Sound in Various Media Section 15: Practical Laboratory Data Update of Laboratory Solvents and Other Liquid Reagents Major update of Density of Solvents as a Function of Temperature Major update of Dependence of Boiling Point on Pressure Section 16: Health and Safety Information Major update of Threshold Limits for Airborne Contaminants Appendix A: Major update of Mathematical Tables Appendix B: Update of Sources of Physical and Chemical Data
