Cancer Precursors is a groundbreaking, multidisciplinary text containing a comprehensive overview of methodological issues associated with the study of pre-cancerous conditions, as well as reviews of the contributions of descriptive, analytical, and molecular epidemiological research to knowledge about cancer precursors at specific anatomical locations. The research focuses on the early natural history of cancers, by helping to define the etiology of precursor lesions, improving the means of detecting them either directly or via testing of surrogate biomarkers, and by elucidating the role of remote causes leading to the early onset of such lesions.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
In this issue of Hematology/Oncology Clinics, guest editor Dr. Elizabeth K. O'Donnell brings her considerable expertise to the topic of Cancer Precursor Syndromes and Their Detection. Top experts focus on cancer precursors for different sites, with articles on the risk-benefit analysis of early interception; plasma cell precursors; early detection and interception of lung cancer, cervical cancer, GI cancers, skin cancer; and head and neck cancer; biomarkers and early detection; and more. - Contains 12 relevant, practice-oriented topics including clonal hematopoiesis of indeterminate potential (CHIP); prostate cancer: early detection and intervention; ductal carcinoma in situ; cancer prevention; and more. - Provides in-depth clinical reviews on cancer precursor syndromes and their detection, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Drawing widely from international sources, the new edition of this reference book on cancer causes, incidence, mortality and survival patterns, also includes chapters on social class, obesity, physical activity and chemoprevention plus other related topics in the field.
WHO Classification of Tumours of Female Reproductive Organs is the sixth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. The book, prepared by 91 authors from 19 countries, contains more than 400 colour images and tables, and more than 2100 references
Psychosocial Stress and Cancer Edited by Cary L. Cooper University of Manchester Institute of Science and Technology The importance of stress in the development of heart disease is well established, but its role in cancer is only just beginning to be investigated. Recent research in humans indicates that various life events, personality pre-dispositions, as well as immunological and central nervous system interactions, may trigger the cancer process, or at the very least accentuate its development. In this book, a number of recognized international authorities provide state-of-the-art statements on the key issues of the subject. Beginning with a review of the findings to date, there follows more in-depth analysis of potential social/psychological precursors to cancer, and the way in which they may influence the aetiology and development of the disease. The final section deals with the way in which psychosocial factors may be managed in cancer patients, and provides a comparative summary of the various methodological approaches utilized in studies exploring the field of psychological oncology. The book will provide a unique digest of current knowledge as well as a starting point for future research, and will be invaluable to all concerned with the study and management of the cancer process. Other Wiley titles on this subject include: Stress Research: Issues for the Eighties Edited by Cary L. Cooper 160 pages February 1983 Mind and Cancer Prognosis Basil A. Stoll, St Thomas’s Hospital and Royal Free Hospital, London 214 pages December 1979 All about Cancer Chris Williams, CRC Medical Oncology Unit, University of Southampton 404 pages April 1983
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Disorders of the ovary can lead to a wide range of endocrinologic and malignant conditions, many of which are linked with fertility. This comprehensive, yet succinct book presents a multidisciplinary approach to address the major issues in diagnosing and managing ovarian disorders. Beginning with the complex functioning of the normal ovary, the editors address many of the major issues in women's health. New chapters on ovarian cysts, menopause, the aging ovary, early detection and risk assessment of ovarian cancer, screening, stage I ovarian cancer and many other topics have been added to this third edition. Assisted reproductive techniques, diagnostic imaging modalities, minimally invasive surgery, and chemotherapy have advanced dramatically and the chapters have been updated accordingly. This well-documented volume has been fully updated with contemporary references and chapters written by current leaders in their field. A must-read for gynecologists, oncologists, obstetricians, pathologists and researchers in human reproductive sciences.
