Cancer Precursors
Cancer Precursors

Author: Eduardo L. Franco

Publisher: Springer Science & Business Media

Published: 2007-05-08

Total Pages: 439

ISBN-13: 0387216057

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Cancer Precursors is a groundbreaking, multidisciplinary text containing a comprehensive overview of methodological issues associated with the study of pre-cancerous conditions, as well as reviews of the contributions of descriptive, analytical, and molecular epidemiological research to knowledge about cancer precursors at specific anatomical locations. The research focuses on the early natural history of cancers, by helping to define the etiology of precursor lesions, improving the means of detecting them either directly or via testing of surrogate biomarkers, and by elucidating the role of remote causes leading to the early onset of such lesions.

How Tobacco Smoke Causes Disease
How Tobacco Smoke Causes Disease

Author: United States. Public Health Service. Office of the Surgeon General

Publisher:

Published: 2010

Total Pages: 728

ISBN-13:

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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

AIDS Pathogenesis
AIDS Pathogenesis

Author: H. Schuitemaker

Publisher: Springer Science & Business Media

Published: 2000-03-31

Total Pages: 300

ISBN-13: 9780792361961

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Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.

The Heterogeneity of Cancer Metabolism
The Heterogeneity of Cancer Metabolism

Author: Anne Le

Publisher: Springer

Published: 2018-06-26

Total Pages: 186

ISBN-13: 331977736X

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Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

WHO Classification of Tumours of Female Reproductive Organs
WHO Classification of Tumours of Female Reproductive Organs

Author: Robert J. Kurman

Publisher: World Health Organization

Published: 2014

Total Pages: 307

ISBN-13: 9789283224358

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WHO Classification of Tumours of Female Reproductive Organs is the sixth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. The book, prepared by 91 authors from 19 countries, contains more than 400 colour images and tables, and more than 2100 references

Psychosocial Stress and Cancer
Psychosocial Stress and Cancer

Author: Cary L. Cooper

Publisher: Ediciones Díaz de Santos

Published: 1984

Total Pages: 348

ISBN-13: 9780471904779

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Psychosocial Stress and Cancer Edited by Cary L. Cooper University of Manchester Institute of Science and Technology The importance of stress in the development of heart disease is well established, but its role in cancer is only just beginning to be investigated. Recent research in humans indicates that various life events, personality pre-dispositions, as well as immunological and central nervous system interactions, may trigger the cancer process, or at the very least accentuate its development. In this book, a number of recognized international authorities provide state-of-the-art statements on the key issues of the subject. Beginning with a review of the findings to date, there follows more in-depth analysis of potential social/psychological precursors to cancer, and the way in which they may influence the aetiology and development of the disease. The final section deals with the way in which psychosocial factors may be managed in cancer patients, and provides a comparative summary of the various methodological approaches utilized in studies exploring the field of psychological oncology. The book will provide a unique digest of current knowledge as well as a starting point for future research, and will be invaluable to all concerned with the study and management of the cancer process. Other Wiley titles on this subject include: Stress Research: Issues for the Eighties Edited by Cary L. Cooper 160 pages February 1983 Mind and Cancer Prognosis Basil A. Stoll, St Thomas’s Hospital and Royal Free Hospital, London 214 pages December 1979 All about Cancer Chris Williams, CRC Medical Oncology Unit, University of Southampton 404 pages April 1983

WHO Classification of Tumours of the Digestive System
WHO Classification of Tumours of the Digestive System

Author: F. T. Bosman

Publisher: International Agency for Research on Cancer

Published: 2010-10-15

Total Pages: 424

ISBN-13:

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"The WHO Classification of Tumours of the Digestive System presented in this book reflects the views of a Working Group that convened for an Editorial and Consensus Conference at the International Agency for Research on Cancer (IARC), Lyon, December 10-12, 2009"--P. [5].

Comprehensive Cervical Cancer Control
Comprehensive Cervical Cancer Control

Author: World Health Organization

Publisher: World Health Organization

Published: 2006

Total Pages: 284

ISBN-13: 9241547006

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Most women who die from cervical cancer, particularly in developing countries, are in the prime of their life. They may be raising children, caring for their family, and contributing to the social and economic life of their town or village. Their death is both a personal tragedy, and a sad and unnecessary loss to their family and their community. Unnecessary, because there is compelling evidence, as this Guide makes clear, that cervical cancer is one of the most preventable and treatable forms of cancer, as long as it is detected early and managed effectively. Unfortunately, the majority of women in developing countries still do not have access to cervical cancer prevention programmes. The consequence is that, often, cervical cancer is not detected until it is too late to be cured. An urgent effort is required if this situation is to be corrected. This Guide is intended to help those responsible for providing services aimed at reducing the burden posed by cervical cancer for women, communities and health systems. It focuses on the knowledge and skills needed by health care providers, at different levels of care.

Inflammation and Cancer
Inflammation and Cancer

Author: Bharat B. Aggarwal

Publisher: Springer

Published: 2014-05-12

Total Pages: 489

ISBN-13: 3034808372

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This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.