A free ebook version of this title is available through Luminos, University of California Press's Open Access publishing program. Visit www.luminosoa.org to learn more. Cancer Intersections is an ethnographic analysis of the complex and paradoxical efforts to access neoliberal, market-based oncological treatments in Colombia, a country where all patients are legally guaranteed access to medical services, including high-cost ones. Drawing on years of fieldwork in the city of Cali, Camilo Sanz explores the deep entanglements between medical, legal, and policy practices that share a common goal of treating and curing cancer but are hindered by bureaucratic procedures, pernicious financial interests, and class politics. Cancer Intersections shows how the interplay of these hurdles dictates the rhythm at which patients access treatment and how even in resource-rich settings, patients suffer because of market imperatives that shape how cancer treatments unfold. Through careful and measured observation, Sanz unveils how a neoliberal universal health care regime delays access to care for those reliant on public assistance, which means that some patients will start expensive treatments only after it is unlikely to change the course of the disease.
Kidney disease and cancer are frequent comorbidities that require specialized knowledge and expertise from both the nephrologist and the oncologist. Written by three pioneers in this growing subspecialty, Onco-Nephrology provides authoritative, definitive coverage of the mechanism and management of these two life-threatening diseases. This unique, single-volume resource covers current protocols and recommends management therapies to arrest kidney failure and allow oncologic treatments to continue and succeed. - Addresses acute and chronic kidney diseases that develop from a variety of cancers. This includes direct kidney injury from the malignancy, paraneoplastic effects of the cancer, and various cancer agents used to treat the malignancy. - Discusses key issues regarding kidney disease in patients with cancer, including conventional chemotherapeutic regimens and new novel therapies (targeted agents and immunotherapies) or the malignancies themselves that may promote kidney injury; patients with chronic kidney disease who acquire cancer unrelated to renal failure; and kidney transplantation, which has been shown to carry an increased risk of cancer. - Contains dedicated chapters for each class of the conventional chemotherapeutic agents, targeted cancer agents, and cancer immunotherapies including the basic science, pathogenic mechanisms of injury, clinical manifestations, and treatment. - Includes special chapters devoted to the individual classes of chemotherapies that relate to kidney disease for quick reference. Discusses increasingly complex problems due to more numerous and specialized anti-cancer drugs, as well as increased survival rates for both cancer and renal failure requiring long-term patient care. - Covers anti-VEGF (antivascular endothelial growth factor) agents and cancer immunotherapies – treatments that are being recognized for adverse kidney effects. - Utilizes a clear, logical format based on the ASN Core Curriculum for Onco-Nephrology, making this reference an excellent tool for board review, as well as a practical resource in daily practice. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
This issue of Dermatologic Clinics, guest edited by Dr. Lindsay C. Strowd of Wake Forest Baptist Health, is devoted to the Intersection of Dermatology and Oncology. This issue focuses on Melanoma, Nonmelanoma Skin Cancer, Cutaneous Lymphoma, Other Cutaneous Malignancies, Special Topics in Skin Cancer Diagnosis and Treatment, Dermatology in the Diagnosis of Non-cutaneous Malignancy, Dermatology in the Management of Non-cutaneous Malignancy, and Genodermatoses with Neoplastic Behavior. Articles in this issue include: Update on current treatment recommendations for primary cutaneous melanoma; Nonsurgical treatments for advanced melanoma; Update on current treatment recommendations for NMSC; Nonsurgical treatments for NMSC; Diagnosis and management of CBCL; Diagnosis and management of CTCL; Lymphomatoid papulosis and other lymphoma-like diseases (PLC, PLEVA, CD30+ disease); Dermatofibrosarcoma protuberans updates; Merkel cell carcinoma updates; Kaposi sarcoma updates; Skin cancer in skin of color patients; Skin cancer detection technology; Paraneoplastic diseases; Cutaneous metastases of internal tumors; Cutaneous side effects of chemotherapy agents; GVHD treatment updates; Phakomatoses (NF, TS); and Hereditary tumor syndromes with skin involvement (Gorlins, Lynch, XP, etc.).
Celebrity culture, health care, and travel attract attention in America’s media-saturated society. These worlds curiously intersect in the study of medical tourism. Although the US touts some of the finest and best-known medical facilities in the world, many jet-setting A-list celebrities, who can well afford the finest of health care, seek treatment far away from home, popularizing international sites, physicians, and procedures. These travelers, whose every move is chronicled by the media, both reflect and influence health care concerns in America. An analysis of these high-profile cases of celebrities with both life-threatening and non life-threatening conditions sheds light on the link between medical tourism and celebrity, showing how health care and entertainment intersect, and the American public responds. The Intersection of Star Culture in America and International Medical Tourism: Celebrity Treatment argues that celebrity cases and media content drive awareness of medical tourism among Americans at a time when the medical system is under intense scrutiny. By popularizing international sites for treatment, procedures not available in the US, and different approaches to patient care, media narratives present options for health care, triggering dialogue on one of America’s most important human welfare issues.
NETosis is a unique form of cell death that is characterized by the release of decondensed chromatin and granular contents to the extracellular space. The initial observation of NETosis placed the process within the context of the innate immune response to infections. Neutrophils, the most numerous leukocytes that arrive quickly at the site of an infection, were the first cell type shown to undergo extracellular trap formation. However, subsequent studies showed that other granulocytes are also capable of releasing nuclear chromatin following stimulation. The extracellular chromatin acts to immobilize microbes and prevent their dispersal in the host. Bacterial breakdown products and inflammatory stimuli induce NETosis and the release of NETs requires enzyme activities. Histones in NET chromatin become modified by peptidylarginine deiminase 4 (PAD4) and cleaved at specific sites by proteases. NETs serve for attachment of bactericidal enzymes including myeloperoxidase, leukocyte proteases, and the cathelicidin LL-37. While the benefit of NETs in an infection appears clear, NETs also figure prominently at the center of various pathologic states. Therefore, it is important for NETs to be efficiently cleared; else digestive enzymes may gain access to tissues where inflammation takes place. Persistent NET exposure at sites of inflammation may lead to a further complication: NET antigens may provoke acquired immune responses and, over time, could initiate autoimmune reactions. Recent studies identified aberrant NET synthesis and/or clearance in inflammatory/autoimmune conditions such as systemic lupus erythematosus (SLE), psoriasis, ANCA-positive vasculitis, gout and Felty’s syndrome. In the case of SLE, for example, it appears that LL-37 exposed in the NETs may be a significant trigger of type I Interferon responses in this disease. Recent evidence also implicates aberrant NET formation in the development of endothelial damage, atherosclerosis and thrombosis. NETosis is thus of interest to researchers who investigate innate immune responses, host-pathogen interactions, chronic inflammatory disorders, cell and vascular biology, biochemistry, and autoimmunity. As we approach the 10-year-anniversary of the initial discovery of NETosis, it is useful and timely to review the so far identified mechanisms and pathways of NET formation, their role in bacterial and fungal defense and their putative importance as inducers of autoimmune responses. We look forward to a rich and rigorous discussion of these and related issues that benefit from interdisciplinary approaches, collaborations and exciting discoveries.
The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.
Evidence from the public health sector demonstrates that health care is only one of the determinants of health, which also include genes, behavior, social factors, and the built environment. These contextual elements are key to understanding why health care organizations are motivated to focus beyond their walls and to consider and respond in unprecedented ways to the social needs of patients, including transportation needs. In June 2016 the National Academies of Sciences, Engineering, and Medicine held a joint workshop to explore partnerships, data, and measurement at the intersection of the health care and transportation sectors. This publication summarizes the presentations and discussions from the workshop.
Available Open Access under CC-BY-NC licence. With an increasingly diverse ageing population, we need to expand our understanding of how social divisions intersect to affect outcomes in later life. This edited collection examines ageing, gender, and sexualities from multidisciplinary and geographically diverse perspectives and looks at how these factors combine with other social divisions to affect experiences of ageing. It draws on theory and empirical data to provide both conceptual knowledge and clear ‘real-world’ illustrations. The book includes section introductions to guide the reader through the debates and ideas and a glossary offering clear definitions of key terms and concepts.
