This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation. Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interested in bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.
Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.
Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.
Regenerated Organs: Future Perspectives provides the translational-research aspects, currently lacking in existing literature, in this rapidly-moving field. The book is divided into six sections: Engineering Approaches, Cardiovascular System, Musculoskeletal Regeneration, Regenerative Neuroscience, Respiratory Research, a Future Outlook and Conclusions. Each chapter is multi-authored by international experts in each area. The book's primary audience is academic faculty and those in industry interested in translational research in regenerative medicine and tissue engineering. Additionally, this book is ideal for graduate students in the field. - Discusses recent advances in tissue and organ fabrication - Provides translational-research aspects that are often lacking in existing literature - Contains chapters that are multi-authored by international experts in the field
Advanced oral and maxillofacial surgery encompasses a vast array of diseases, disorders, defects, and deformities as well as injuries of the mouth, head, face, and jaws. It relates not only to treatment of impacted teeth, facial pain, misaligned jaws, facial trauma, oral cancers, jaw cysts, and tumors but also to facial cosmetic surgery and placement of dental and facial implants. This specialty is evolving alongside advancements in technology and instrumentation. Volume 1 has topped 132,000 chapter downloads so far, and Volume 2 is being downloaded at the same pace! Volume 3 is basically the sequel to Volumes 1 and 2; 93 specialists from nine countries contributed to 32 chapters providing comprehensive coverage of advanced topics in OMF surgery.
Periodontitis is a disease that affects more than half the adult population in the world. Treatment is often based on ancient recommendations consisting in mechanically removing material from damaged zones. However, novel therapeutic management strategies exist, from prevention to efficient treatment, and regeneration. The need of integrative approaches to circumvent this worldwide pledge can be achieved through: A better understanding of this complex disease by promoting scientific research and a comprehensive multidisciplinary approach, including epidemiology, microbiology, immunology, physiology, therapeutics, psychology, etc. A better outreach by promoting vulgarization and recommendations for health professionals. A better information of the empowered patients, leading them to consider prevention and to take part in their therapeutic course. The book “Periodontitis: Advances in Experimental Research” includes a timely collection of chapters covering all the fields of research about periodontitis, consisting in concise reviews by the best specialists themselves and with clinical perspectives for periodontitis. Recent technological advances have allowed to explore shadowed areas of periodontology. The book “Periodontitis: Advances in Experimental Research” is a unique occasion to set a milestone for a more integrated field of periodontitis, with a broad scientific, medical, and public audience thanks to dedicated sections in each chapter: Abstract and main body (scientific audience and expert clinicians) Highlights (scientific audience and clinicians) Impact for Practice (clinicians and economical/political decision makers) Summary for Patients (patients and economical/political decision makers)
In this issue of Dental Clinics, guest editors Alpdogan Kantarci, Andreas Stavropoulos, and Anton Sculean bring their considerable expertise to the topic of Biologics and Biology-based Regenerative Treatment Approaches in Periodontics. Provides in-depth, clinical reviews on the latest updates in Biologics and Biology-based Regenerative Treatment Approaches in Periodontics, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.
This book is an edited collection of all the achievements of the main members of the Dental Division of the Japanese Society for Regenerative Medicine, which derives from the Japanese Forum for Regenerative Dentistry established in 2003. Scientific meetings held by these organizations gleaned specific experiences of the academic community as well as clinical experiences of the most renowned experts in the field of dentistry. The editors are especially proud of bringing together leading biologists and dentists of all specialties. This unique collection of reports on the achievements and experiences of experts from all over the world represents the current spectrum of possibilities in tissue engineering of substitutes not only in dentistry but also in medicine. This book has been produced and distributed with the support from The Japanese Society for Regenerative Medicine.
