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Author: Gary P. Pisano
Publisher: Harvard Business Press
Published: 2006
Total Pages: 278
ISBN-13: 9781591398400
DOWNLOAD EBOOKWhy has the biotechnology industry failed to perform up to expectations? This book attempts to answer this question by providing a critique of the industry. It reveals the causes of biotech's problems and offers an analysis on how the industry works. It also provides prescriptions for companies, seeking ways to improve the industry's performance.
Author: Catherine Regnault-Roger
Publisher: Springer Nature
Published: 2024-01-01
Total Pages: 163
ISBN-13: 3031382374
DOWNLOAD EBOOKThe evolution of genome’s modification by genetic engineering was characterized by a major technological breakthrough with the discovery of CRISPR in 2012. A distinction is now made between first-generation biotechnologies developed in the 20th century and current second-generation biotechnologies, NGT or New Genomic Techniques, including genome editing. How do we consider these genomic modifications compared to those that occur spontaneously in nature? What are the applications of these techniques in the fields of plants, animals, and human health? What prospects in terms of development and independence for countries and at least what regulations are in force on the different continents? The book questions what GMOs are, genome editing products and the place of genomic transformations today and tomorrow in our societies. It tries to give some geostrategic and regulatory benchmarks on biotech products in order to better understand the current issues.
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Published: 2017-07-28
Total Pages: 231
ISBN-13: 0309452058
DOWNLOAD EBOOKBetween 1973 and 2016, the ways to manipulate DNA to endow new characteristics in an organism (that is, biotechnology) have advanced, enabling the development of products that were not previously possible. What will the likely future products of biotechnology be over the next 5â€"10 years? What scientific capabilities, tools, and/or expertise may be needed by the regulatory agencies to ensure they make efficient and sound evaluations of the likely future products of biotechnology? Preparing for Future Products of Biotechnology analyzes the future landscape of biotechnology products and seeks to inform forthcoming policy making. This report identifies potential new risks and frameworks for risk assessment and areas in which the risks or lack of risks relating to the products of biotechnology are well understood.
Author: National Research Council
Publisher: National Academies Press
Published: 2015-06-29
Total Pages: 158
ISBN-13: 0309316553
DOWNLOAD EBOOKThe tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.
Author: Chakravarthi Mohan
Publisher: Springer
Published: 2017-08-09
Total Pages: 184
ISBN-13: 3319589466
DOWNLOAD EBOOKThis book provides exhaustive information on several recent technologies that are employed for sugarcane improvement through biotechnology and will be of great interest to plant scientists, biotechnologists, molecular biologists and breeders who work on sugarcane crop. Topics discussed in this volume include genomics and transcriptomics, transgenic sugarcane for trait improvement, potential candidate promoters, new strategies for transformation, molecular farming, sugarcane as biofuel, chloroplast transformation, and genome editing.
Author: Donald L. Drakeman
Publisher: Oxford University Press
Published: 2022
Total Pages: 241
ISBN-13: 0195084004
DOWNLOAD EBOOK"Beginning in the 1970s, several scientific breakthroughs promised to transform the creation of new medicines. As investors sought to capitalize on these Nobel Prize-winning discoveries, the biotech industry grew to thousands of small companies around the world. Each sought to emulate what the major pharmaceutical companies had been doing for a century or more, but without the advantages of scale, scope, experience, and massive resources. How could a large collection of small companies, most with fewer than 50 employees, compete in one of the world's most breathtakingly expensive and highly regulated industries? This book shows how biotech companies have met the challenge by creating nearly 40% more of the most important treatments for unmet medical needs. Moreover, they have done so with much lower overall costs. The book focuses on both the companies themselves and the broader biotech ecosystem that supports them. Its portrait of the crucial roles played by academic research, venture capital, contract research organizations, the capital markets, and pharmaceutical companies shows how a supportive environment enabled the entrepreneurial biotech industry to create novel medicines with unprecedented efficiency. In doing so, it also offers insights for any industry seeking to innovate in uncertain and ambiguous conditions. Looking to the future, it concludes that biomedical research will continue to be most effective in the hands of a large group of small companies as long as national healthcare policies allow the rest of the ecosystem to continue to thrive"--
Author: Krishna R. Dronamraju
Publisher: World Scientific
Published: 2008
Total Pages: 485
ISBN-13: 9812775013
DOWNLOAD EBOOKThe principal message of this book is that thermodynamics and statistical mechanics will benefit from replacing the unfortunate, misleading and mysterious term "entropy" with a more familiar, meaningful and appropriate term such as information, missing information or uncertainty. This replacement would facilitate the interpretation of the "driving force" of many processes in terms of informational changes and dispel the mystery that has always enshrouded entropy. It has been 140 years since Clausius coined the term "entropy"; almost 50 years since Shannon developed the mathematical theory of "information"--Subsequently renamed "entropy." In this book, the author advocates replacing "entropy" by "information," a term that has become widely used in many branches of science. The author also takes a new and bold approach to thermodynamics and statistical mechanics. Information is used not only as a tool for predicting distributions but as the fundamental cornerstone concept of thermodynamics, held until now by the term "entropy." The topics covered include the fundamentals of probability and information theory; the general concept of information as well as the particular concept of information as applied in thermodynamics; the re-derivation of the Sackur-Tetrode equation for the entropy of an ideal gas from purely informational arguments; the fundamental formalism of statistical mechanics; and many examples of simple processes the "driving force" for which is analyzed in terms of information.
Author: Marcus Wohlsen
Publisher: Penguin
Published: 2012-07-31
Total Pages: 274
ISBN-13: 1617230073
DOWNLOAD EBOOKBill Gates recently told Wired that if he were a teenager today, he would be hacking biology. "If you want to change the world in some big way," he says, "that's where you should start-biological molecules." The most disruptive force on the planet resides in DNA. Biotech companies and academic researchers are just beginning to unlock the potential of piecing together life from scratch. Champions of synthetic biology believe that turning genetic code into Lego-like blocks to build never-before-seen organisms could solve the thorniest challenges in medicine, energy, and environmental protection. But as the hackers who cracked open the potential of the personal computer and the Internet proved, the most revolutionary discoveries often emerge from out-of-the-way places, forged by brilliant outsiders with few resources besides boundless energy and great ideas. In Biopunk, Marcus Wohlsen chronicles a growing community of DIY scientists working outside the walls of corporations and universities who are committed to democratizing DNA the way the Internet did information. The "biohacking" movement, now in its early, heady days, aims to unleash an outbreak of genetically modified innovation by making the tools and techniques of biotechnology accessible to everyone. Borrowing their idealism from the worlds of open-source software, artisinal food, Internet startups, and the Peace Corps, biopunks are devoted advocates for open-sourcing the basic code of life. They believe in the power of individuals with access to DNA to solve the world's biggest problems. You'll meet a new breed of hackers who aren't afraid to get their hands wet, from entrepreneurs who aim to bring DNA-based medical tools to the poorest of the poor to a curious tinkerer who believes a tub of yogurt and a jellyfish gene could protect the world's food supply. These biohackers include: -A duo who started a cancer drug company in their kitchen -A team who built an open-source DNA copy machine -A woman who developed a genetic test in her apartment for a deadly disease that had stricken her family Along with the potential of citizen science to bring about disruptive change, Wohlsen explores the risks of DIY bioterrorism, the possibility of genetic engineering experiments gone awry, and whether the ability to design life from scratch on a laptop might come sooner than we think.
Author: Richard Sherlock
Publisher: Rowman & Littlefield
Published: 2002
Total Pages: 668
ISBN-13: 9780742513778
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Author: M O'Neill
Publisher: Elsevier
Published: 2012-05-02
Total Pages: 414
ISBN-13: 1908818158
DOWNLOAD EBOOKA biotech manager's handbook lays out - in a simple, straightforward manner - for the manager or would-be entrepreneur the basic principles of running a biotech company. Most managers in biotechnology companies are working in their first company or in their first managerial role. Their expertise and experience in the scientific part of the work can be taken as a given but there is a whole range of other skills to be learned and areas of expertise to come to terms with. Small companies do not have big budgets to hire people or time to become an expert in so many areas. The book starts by outlining the state of the biopharmaceutical industry and goes on to explain the importance of planning (no matter what the size of the company). Succeeding chapters deal with the basics of intellectual property, perspectives from a university technology transfer office and how to raise some initial funding from an investor and entrepreneur. - No other 'how to' manual exists for this sector - Written by a range of expert professionals in each area, all in one book - Is the only 'bench to bedside' book covering the whole spectrum of development
