Bioorganic Marine Chemistry
Bioorganic Marine Chemistry

Author:

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 192

ISBN-13: 3642727263

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The present series, "Bio-organic Marine Chemistry," is being launched at a time when we have the fundamental knowledge and the requisite instrumentation to probe the molecular basis of many biological phenomena. The final volume of "Marine Natural Products-Chemical and Biological Perspectives" (Academic Press), which may be con sidered the precursor of this series, was published in 1983. In that series, which I edited, primary emphasis was placed on molecular structure and phyletic relationships. This focus was compatible with the major concerns of a growing research community in the field of marine natural products. Moreover, a need existed for timely reviews of a rapidly expanding and widely scattered primary literature. As I read again the Preface to Volume 1 (1978), I am amazed at the changes in direction and emphasis which have taken place during these few intervening years. Sufficient basic data are now at hand to gauge the breadth of the marine natural product spectrum and to raise questions of functions, both within and outside the marine ecosystem. Although we have few answers, the questions have become meaningful and pointed. Furthermore, the task of tracking and cataloguing the steady stream of fascinating new structures has been assumed by Faulkner's periodic surveys in Natural Product Reports, a bimonthly publication of the Royal Society of Chemistry. The study of marine natural products remains firmly anchored in chemistry, i. e. in molecular integrity, yet continues to seek greater involvement in functional biology.

Bioorganic Marine Chemistry
Bioorganic Marine Chemistry

Author:

Publisher: Springer Science & Business Media

Published: 2013-03-08

Total Pages: 148

ISBN-13: 3642483461

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Burgeoning research into marine natural products during the past two decades has in no small measure been due to an heightened and world-wide interest in the ocean, to the development of new sophisticated computer-driven instrumentation, and to major advances in separation science. Organic chemists have been fully aware that processes in living systems occur in an aqueous medium. Nevertheless, the chemists who have specialized in the study of small molecules have found it expedient to use organic rather than aqueous solvents for the isolation and manipulation of secondary metabolites. The emergence of new chromatographic techniques, the promise of rewarding results, not to mention the relevance of polar molecules to life itself, have contributed to a new awareness of the importance of organic chemistry in an aqueous medium. The first chapter in Volume 2 of Bioorganic Marine Chemistry reflects the growing interest and concern with water-soluble com pounds. Quinn, who pioneered the separation of such molecules, has contributed a review which closely links techniques with results and is based on practical experience. The second chapter, by Stonik and Elyakov, examines the vast chemical literature of the phylum Echinodermata - over one fourth of it in difficulty accessible Russian language publications. The Soviet authors evaluate the data for their suitability as chemotaxonomic markers.

Bioorganic Chemistry
Bioorganic Chemistry

Author: Ulf Diederichsen

Publisher: John Wiley & Sons

Published: 1999-12-16

Total Pages: 487

ISBN-13: 3527296654

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The understanding of (patho)physiological processes - the biosynthesis of biomolecules such as enzymes, nucleic acids, and secondary metabolites; the pathways of signaltransduction; or the function of pharmaceutical agents - is of increasing importance not only for drug research but also for the development of new synthetic methods in organic chemistry and biochemistry. In a truly interdisciplinary way bioorganic chemistry unites the central questions of biochemistry, medicinal chemistry, organic chemistry, and spectroscopy. This book fills a void in this rapidly growing field of chemistry and gives a thorough yet understandable introduction for advanced students and researchers alike. Contributions of more than sixty scientists provide a topical overview of recent advances in: drug development based on natural products; the biosynthesis, activity, and application of enzymes; carbohydrates; peptides; nucleic acids; analytical methods in bioorganic chemistry. This book will be an appetizer for all - students and researchers alike - seeking orientation in this fascinating field of chemistry.

Marine Chemical Ecology
Marine Chemical Ecology

Author: James B. McClintock

Publisher: CRC Press

Published: 2001-06-13

Total Pages: 626

ISBN-13: 1420036602

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The interdisciplinary field of marine chemical ecology is an expanding and dynamic science. It is no surprise that the breadth of marine organisms studied expanded in concert with developments in underwater technology. With its up-to-date subject reviews by experts, Marine Chemical Ecology is the most current, comprehensive book on the subject. The

Bioorganic Marine Chemistry
Bioorganic Marine Chemistry

Author: A.R. Davis

Publisher: Springer

Published: 1989-10-06

Total Pages: 192

ISBN-13:

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The first three chapters of Vol. 3 of Bio-organic Marine Chemistry deal with the chemistry and function of peptides. Chapter 1 by Ireland and coworkers serves as an introduction to marine-derived peptides. It is arranged phyletically and encompasses the entire range from dipeptides to a compound with 95 amino acid residues. Peptides involved in primary metabolism and hence belonging to the realm of macromolecular biochemistry are excluded. However, it might be mentioned in passing that the dividing line between large and small molecule chemistry is continually becoming less distinct. Not only are more compounds of intermediate size, from 1,000 to 10,000 dalton, being discovered, but instruments and techniques, particularly in mass spectrometry and nuclear magnetic resonance have been developed for their structural elucidation by what is considered small molecule methodology. Two groups of peptides are discussed in separate chapters. Biologists who have observed and described the mating behavior of diverse species of marine invertebrates have long surmised that a chemical mechanism might be operating in many cases of individual as well as mass fertilization. The chemical activators of sea urchin sperm prove to be a series of peptides, whose structures and activity are discussed by Suzuki.

Cyclic Peptides
Cyclic Peptides

Author: Jesko Koehnke

Publisher: Royal Society of Chemistry

Published: 2017-12-14

Total Pages: 392

ISBN-13: 1788013778

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Cyclic peptides are increasingly employed as chemical tools in biology and drug discovery. They have gained a lot of interest as alternative sources of new drugs to traditional small molecules. This book introduces cyclic peptides and provides a thorough overview of biosynthetic and fully synthetic approaches to their preparation. Following an introduction to cyclic peptides, biosynthetic and traditional chemical routes to cyclic peptides are reviewed. Due to their size, their synthesis is not trivial. Recent advances in the incorporation of novel structural units are presented in addition to how synthesis and biological methods can be combined. The chemical analysis of this molecular class is also discussed. Furthermore, chapters detail the progression of cyclic peptides as tools in biology and as potential drugs, providing a future vision of their importance. In total, this book provides the reader with a comprehensive view of the state-of-the-art of cyclic peptides, from construction to possible clinical utility. This book will be an essential resource for students, researchers and scientists within industry in medicinal, bioorganic, natural product and analytical chemistry fields.