Biomedical Applications of Polarimetry
Biomedical Applications of Polarimetry

Author: Nathaniel Owen King

Publisher:

Published: 2020

Total Pages: 0

ISBN-13:

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Non- or minimally-invasive data collection is highly desirable for gathering the broad base of information that facilitates moving technology to the point of care. Polarimetry has been making this transition for years. Early forms of polarization-sensitive optics involved custom multiplexing a series of images to generate a single image, but today's snapshot polarimeters are readily commercially available.The research presented in this dissertation advances three areas of polarimetric imaging: First, this research develops a reflectance-based measurement for tracking changes in the alignment of dynamically loaded soft tissue, specifically tendon. This work highlights a range of mounting angles across which signal strength is agnostic to sensor location. Second, it compares a high dynamic range division-of-focal-plane (DoFP) polarimeter with a standard DoFP polarimeter, highlighting both the current limitations of polarimetry and future areas for sensor improvement. The incorporation of a DoFP polarization filter with a high dynamic range sensor represents an important advance in DoFP polarimetry, in that the high-dynamic range pixels can compensate for the reduced photon flux at the photosensor caused by the nano-wire filters. Finally, this research identifies a polarization-based neural signal, with major implications for non-invasively tracking neural activity, including the first tandem recording of optical and electrical activity from a single region. In conclusion, this work makes important advances across a range of polarimetric applications.

Optical Polarization in Biomedical Applications
Optical Polarization in Biomedical Applications

Author: Valery V. Tuchin

Publisher: Springer Science & Business Media

Published: 2006-10-12

Total Pages: 281

ISBN-13: 3540453210

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Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues. This theory uses the modified transfer equation for Stokes parameters and predicts the polarization structure of multiple scattered optical fields. The backscattering polarization matrices (Jones matrix and Mueller matrix) important for noninvasive medical diagnostic are introduced. The text also describes a number of diagnostic techniques such as CW polarization imaging and spectroscopy, polarization microscopy and cytometry. As a new tool for medical diagnosis, optical coherent polarization tomography is analyzed. The monograph also covers a range of biomedical applications, among them cataract and glaucoma diagnostics, glucose sensing, and the detection of bacteria.

Optical Polarimetric Modalities for Biomedical Research
Optical Polarimetric Modalities for Biomedical Research

Author: Nirmal Mazumder

Publisher: Springer Nature

Published: 2023-07-25

Total Pages: 455

ISBN-13: 3031318528

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This book focuses on polarization microscopy, a powerful optical tool used to study anisotropic properties in biomolecules, and its enormous potential to improve diagnostic tools for various biomedical research. The interaction of polarized light with normal and abnormal regions of tissue reveals structural information associated with its pathological condition. Diagnosis using conventional microscopy can be time-consuming, as pathologists require an hour to freeze and stain tissue slices from suspected patients. In comparison, polarization microscopy more quickly distinguishes abnormal tissue and provides better microstructural information of samples, even in the absence of staining. This book provides a basic understanding of the properties of polarized light, a description of the polarization microscope, and a mathematical formalism of Mueller matrix polarimetry. The authors discuss various advanced linear and nonlinear optical techniques such as optical coherence tomography (OCT), reflectance and transmission spectroscopy, fluorescence, multiphoton excitation, second harmonic generation, Raman microscopy, and more. They explore the exciting potential of integrating polarimetry with these techniques for possible applications in different areas of biomedical research, as well as the associated challenges. Including the most recent developments on the topic, this book serves as a modern guide to polarization microscopy and advancements in its use in biomedical research.

Liquid Crystals: Frontiers In Biomedical Applications
Liquid Crystals: Frontiers In Biomedical Applications

Author: Gregory P Crawford

Publisher: World Scientific

Published: 2007-08-13

Total Pages: 514

ISBN-13: 981447603X

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The confluence of the fields of liquid crystals and biomedical engineering is resulting in remarkable interdisciplinary research. This book focuses on the potential for inherently translational research in one field of engineering to radically alter the scope of another. The text reviews the exciting advances being made in displays, spectroscopy, sensors and diagnostics, biomimicking, actuators and lasers with regards to liquid crystalline materials, and biomedicine. The liquid crystal field — which has delivered revolutionary devices in the display, optics, and telecommunications industries — is now poised to make significant inroads into biology, medicine, and biomedical engineering.

Polarized Light in Biomedical Imaging and Sensing
Polarized Light in Biomedical Imaging and Sensing

Author: Jessica C. Ramella-Roman

Publisher: Springer Nature

Published: 2022-11-14

Total Pages: 362

ISBN-13: 3031047419

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This book focuses on biomedical applications of polarized light, covering instrumentation and modeling specific to the field. This will be the first book, written by leading researchers in the field, to tackle this important topic. Readers will learn the fundamentals of polarized light transport and how to develop instrumentation for clinical and preclinical studies. They will also become familiar with the latest advancement in data analysis and image processing for a variety of medical applications. The book is dedicated specifically to the biomedical community, including scientists, engineers, and physicians working on the development of instrumentation for clinical and preclinical use. Emphasizes biomedical imaging and sensing; Describes new computational approaches with examples; Provides detailed descriptions of novel instrumentation.

Advanced Photonics Methods for Biomedical Applications
Advanced Photonics Methods for Biomedical Applications

Author: Edik Rafailov

Publisher: CRC Press

Published: 2023-07-31

Total Pages: 186

ISBN-13: 1000880095

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Advanced photonics methods for biomedical applications give researchers in universities and industries, and clinicians an overview of the novel tools for cancer diagnostics and treatment. This book provides researchers and professionals in the area of biomedical photonics with a toolbox of novel methodologies for biomedical applications, including health diagnostics, cancer detection, and treatment. It covers the theory, modeling, and design of each method, alongside their applications, fabrication, characterization, and measurements in clinical practice. A wide scope of concepts concerning innovative science and technologies of medicine will be covered, providing the readers with the latest research, developments, and technologies. It will also be a valuable resource for students and early-career researchers, alongside those involved in the design of the novel photonics-based techniques for health diagnostics and cancer detection and treatment. Key features • Discusses novel methods of cancer diagnostics and cancer treatment. • Details non and minimally invasive photonics techniques. • Explores the applications of machine learning and artificial intelligence to these novel techniques.

The Use of Polarized Light for Biomedical Applications
The Use of Polarized Light for Biomedical Applications

Author: Justin Shekwoga Baba

Publisher:

Published: 2003

Total Pages:

ISBN-13:

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Polarized light has the ability to increase the specificity of the investigation of biomedical samples and is finding greater utilization in the fields of medical diagnostics, sensing, and measurement. In particular, this dissertation focuses on the application of polarized light to address a major obstacle in the development of an optical based polarimetric non-invasive glucose detector that has the potential to improve the quality of life and prolong the life expectancy of the millions of people afflicted with the disease diabetes mellitus. By achieving the mapping of the relative variations in rabbit corneal birefringence, it is hoped that the understanding of the results contained herein will facilitate the development of techniques to eliminate the effects of changing corneal birefringence on polarimetric glucose measurement through the aqueous humor of the eye. This dissertation also focuses on the application of polarized light to address a major downside of cardiovascular biomechanics research, which is the utilization of toxic chemicals to prepare samples for histological examination. To this end, a polarization microscopy image processing technique is applied to non-stained cardiovascular samples as a means to eliminate, for certain cardiac samples, the necessity for staining using toxic chemicals. The results from this work have the potential to encourage more investigators to join the field of cardiac biomechanics, which studies the remodeling processes responsible for cardiovascular diseases such as myocardial infarct (heart attacks) and congestive heart failure. Cardiovascular disease is epidemic, particularly amongst the population group older than 65 years, and the number of people affected by this disease is expected to increase appreciably as the baby boomer generation transitions into this older, high risk population group. A better understanding of the responsible mechanisms for cardiac tissue remodeling will facilitate the development of better prevention and treatment regimens by improving the early detection and diagnosis of this disease.

Tissue Optics
Tissue Optics

Author: Valery Tuchin

Publisher:

Published: 2015

Total Pages: 988

ISBN-13: 9781628415162

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This third edition of the biomedical optics classic Tissue Optics covers the continued intensive growth in tissue optics—in particular, the field of tissue diagnostics and imaging—that has occurred since 2007. As in the first two editions, Part I describes fundamentals and basic research, and Part II presents instrumentation and medical applications. However, for the reader’s convenience, this third edition has been reorganized into 14 chapters instead of 9. The chapters covering optical coherence tomography, digital holography and interferometry, controlling optical properties of tissues, nonlinear spectroscopy, and imaging have all been substantially updated. The book is intended for researchers, teachers, and graduate and undergraduate students specializing in the physics of living systems, biomedical optics and biophotonics, laser biophysics, and applications of lasers in biomedicine. It can also be used as a textbook for courses in medical physics, medical engineering, and medical biology.