Research to Develop Biomedical Applications of Free Electron Laser Technology

Research to Develop Biomedical Applications of Free Electron Laser Technology

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Published: 2004

Total Pages: 0

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Specific Aim 1: Develop and test plaque characterization criteria based on bireftingence. Coronary artenes were obtained at autopsy and imaged with the existing OCT system in our laboratory. The specimens were opened and imaged at normal body temperature (37-C) in saline. To ensure proper registration of OCT images with histolog the image location was marked with ink viewable on the OCT image and in the histology section. Routine histologic processing was performed using H & E, Elastic and Movat's pentachrome stains. Trichrome was used for fibrous tissue identification. Individual images were oriented and scaled to match histology. In the OCT images, the axial periodicity of the birefringence banding was measured using image processing software. A set of 20 correlated OCT and histology pairs were used to identify characterization criteria basal on birefringence. Our results indicated that fibrous plaque provides a strong birefringence as measured by OCT while lipid rich and calcific plaques can be identified by a complete loss of birefringenee.


Biomedical Studies Using Free Electron Laser and Other Laser Systems

Biomedical Studies Using Free Electron Laser and Other Laser Systems

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Published: 1995

Total Pages: 40

ISBN-13:

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Baylor Research Institute, in collaboration with the Dept. of Biomedical Engineering at U.T. Austin and the Dept. of Laser Science at UT-M.D. Anderson hospital in Houston evaluated potential uses for high peak power pulsed and continuous wave lasers and the free-electron lasers at Duke, Stanford, and Vanderbilt for medical use. Resulting developments for potential medical use include eradication of viruses in blood banking, development of photoproducts for use in treatment of AIDS and cancer, photochemicals for non-thermal tissue welding, devices to augment thermal welding, systems for cartilage repair, combined wavelength lasers for tissue hemostasis and ablation, and a new family of photochemicals for use in tracking tumors and with potential as bonding agents in material science. Basic knowledge of laser-tissue interactions was developed.


Development and Applications of Free Electron Lasers

Development and Applications of Free Electron Lasers

Author: Jia Chen

Publisher: CRC Press

Published: 1997-05-22

Total Pages: 176

ISBN-13: 9789056995027

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Provides a comprehensive overview of the field of free electron lasers. Each chapter is based on a graduate-level lecture given by an internationally-known expert in the field, and is self-contained, beginning with introductory background material and culminating in an in-depth discussion of the author's current research. Written with both the student physicist and the active researcher in mind, this book is sure to be an invaluable reference for graduate students and professionals alike.


Free Electron Lasers 2000

Free Electron Lasers 2000

Author: V.N. Litvinenko

Publisher: Gulf Professional Publishing

Published: 2005-12-27

Total Pages: 790

ISBN-13: 9780444509390

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The 22nd International Free Electron Laser Conference and 7th FEL User Workshop were held August 13-18, 2000 at Washington Duke Inn and Golf Club in Durham, North Carolina, USA. The conference and the workshop were hosted by Duke University's Free Electron laser (FEL) Laboratory. Following tradition, the FEL prize award was announced at the banquet. The year 2000 FEL prize was awarded to three scientists propelling the limits of high power FELs: Steven Benson, Eisuke Minehara and George Neill. The conference program was comprised of traditional oral sessions on First Lasing, FEL theory, storage ring FELs, linac and high power FELs, long wavelength FELs, SASE FELs, accelerator and FEL physics and technology, and new developments and proposals. Two sessions on accelerator and FEL physics and technology reflected the emphasis on the high quality of accelerators and components for modern FELs. The breadth of the applications was presented in the workshop oral sessions on materials processing, biomedical and surgical applications, physics and chemistry as well as on instrumentation and methods for FEL applications. A special oral session was dedicated to FEL center status reports for users to learn more about the opportunities with FELs. As usual, the oral sessions were supplemented by poster sessions with in-depth discussions and communications. The FEL physicists and FEL users had excellent opportunities to interact throughout the duration of the event, culminating a Joint Sessions. The year 2000 was very successful being marked by lasing with two SASE and one storage ring short-wavelength FELs, and by the first human surgery with the use of FEL, to mention but a few. The International Program Committee and chairs of the sessions had the challenging and exciting problem of selecting invived and contributed talks for the conferences and the workshop from the influx of abstracts mentioning new results and ideas. The success of the conference was determined by these contributions. Scientists from 15 countries gave 70 talks, presented 176 posters and submitted 146 papers, which are published in the present volume of proceedings.


Lasers

Lasers

Author: Charles Blain

Publisher: Nova Publishers

Published: 2002

Total Pages: 214

ISBN-13: 9781590332252

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Developments in lasers continue to enable progress in many areas such as eye surgery, the recording industry and dozens of others. This book presents citations from the book literature for the last 25 years and groups them for ease of access which is also provided by subject, author and titles indexes.


Free Electron Lasers 1998. Proceedings of the Twentieth International Free Electron Laser Conference Held in Williamsburg, Virginia, USA, on August 16-21, 1998

Free Electron Lasers 1998. Proceedings of the Twentieth International Free Electron Laser Conference Held in Williamsburg, Virginia, USA, on August 16-21, 1998

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Published: 1999

Total Pages: 636

ISBN-13:

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This is a compilation of reviewed papers presented at the 20th International Free Electron Laser Conference covering the present state of the art of FEL technology. The approach to the scientific program utilized a select group of international scientists from the program committee to choose general topics for the various sessions. They appointed session chairs for each of those areas to choose contributed and invited talks in the field from the most current research activities in progress. Sessions highlighting research in the following topics were: New Lasing, FEL Theory, SASE FELs, Accelerator Technology, FEL Technology, Linac-Based FELS, Storage-Ring-Based FELs, UV and X-ray Sources, and New Concepts. In addition, the breadth of interest in applying FELs is evident from the session topics held at the Users Workshop: Physics and Chemistry Research, Applications Research, Industrial Applications, Biomedical, Biophysical, Biochemical, and Photochemical Applications, Applications in Condensed Matter, Materials, Plasmas, Semiconductors, and Surface Physics.


Biomedical Aspects of the Laser

Biomedical Aspects of the Laser

Author: Leon Goldman

Publisher: Springer Science & Business Media

Published: 2013-11-09

Total Pages: 241

ISBN-13: 3642857973

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This book is a review of past and current studies and future plans of the Laser Laboratory in Cincinnati and some of the contributions of laser research groups in other medical centers. Special thanks are due to the Directing Physicist of the Laser Labora tory, R. James Rockwell. Without his advice, constant supervision and corrections, this enthusiastic investigator would continue to upset even many more people than he has done already. The excuse, of course, is to stimulate much needed interest and controlled research and development of the laser for biology and medicine. The Associate Research Physicist, Ralph Schooley, has worked with many phases of laser research but especially in Q spoiling, Raman spectroscopy, and the almost alchemy of holography. Holography, as of now, provides many opportunities for Gumperson's Law, "If anything can go wrong, it will. " Sincere appreciation is expressed to the Surgeons in the Laser Labora tory, who have supplied clinical and investigative surgical supervision often under great difficulties, Dr. V. E. Siler and Dr. Bruce Henderson. We are grateful for help from the Directing Biologist of the Laser Labo ratory, Edmond Ritter, the Director of Laser Neurosurgery, Dr. Thomas Brown and the Professor of Neurosurgery, Dr. Robert McLaurin, for important and basic work in laser neurosurgery. Special thanks are given to Robert Meyer, who has given most of the treatments in careful and skillful fashion, and his associate, Robert Otten.


Medical/Materials Research and Applications of Free Electron Laser and Related Technologies

Medical/Materials Research and Applications of Free Electron Laser and Related Technologies

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Published: 1991

Total Pages: 18

ISBN-13:

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To investigate biomedical and materials laser-optical systems that have potential clinical and industrial applications. To develop clinical and industrial applications of Free-Electron laser technology and related broadly wavelength tunable, short pulse, ultrafast, high peak power, high average power laser systems that are efficient, compact, reliable and clinically and commercially practical systems. To carry out actual FEL experiments with collaborators at existing FEL facilities at Duke, Vanderbilt and Stanford Universities.