The Handbook of Biomarkers
The Handbook of Biomarkers

Author: Kewal K. Jain

Publisher: Springer Science & Business Media

Published: 2010-02-06

Total Pages: 509

ISBN-13: 1607616858

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Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain’s Handbook of Biomarkers thoroughly describes many different types of biomarkers and their discovery using various "-omics" technologies, such as proteomics and metabolomics, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important emerging trends in healthcare today.

Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease
Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2017-12-21

Total Pages: 335

ISBN-13: 0309462568

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Since 1938 and 1941, nutrient intake recommendations have been issued to the public in Canada and the United States, respectively. Currently defined as the Dietary Reference Intakes (DRIs), these values are a set of standards established by consensus committees under the National Academies of Sciences, Engineering, and Medicine and used for planning and assessing diets of apparently healthy individuals and groups. In 2015, a multidisciplinary working group sponsored by the Canadian and U.S. government DRI steering committees convened to identify key scientific challenges encountered in the use of chronic disease endpoints to establish DRI values. Their report, Options for Basing Dietary Reference Intakes (DRIs) on Chronic Disease: Report from a Joint US-/Canadian-Sponsored Working Group, outlined and proposed ways to address conceptual and methodological challenges related to the work of future DRI Committees. This report assesses the options presented in the previous report and determines guiding principles for including chronic disease endpoints for food substances that will be used by future National Academies committees in establishing DRIs.

Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease
Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2010-06-25

Total Pages: 335

ISBN-13: 0309157277

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Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.

Nutrition in the Prevention and Treatment of Disease
Nutrition in the Prevention and Treatment of Disease

Author: Ann M. Coulston

Publisher: Academic Press

Published: 2017-04-28

Total Pages: 1075

ISBN-13: 0128029471

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Nutrition in the Prevention and Treatment of Disease, Fourth Edition, is a compilation of current knowledge in clinical nutrition and an overview of the rationale and science base of its application to practice in the prevention and treatment of disease. In its fourth edition, this text continues the tradition of incorporating new discoveries and methods related to this important area of research Generating and analyzing data that summarize dietary intake and its association with disease are valuable tasks in treating disease and developing disease prevention strategies. Well-founded medical nutrition therapies can minimize disease development and related complications. Providing scientifically sound, creative, and effective nutrition interventions is both challenging and rewarding. - Two new chapters on metabolomics and translational research, which have come to be used in nutrition research in recent years. The new areas of study are discussed with the perspective that the application of the scientific method is by definition an evolutionary process. - A new chapter on Genetics and Diabetes which reviews the latest research on causal genetic variants and biological mechanisms responsible for the disease, and explores potential interactions with environmental factors such as diet and lifestyle. - Includes all major "omics" – the exposome, metabolomics, genomics, and the gut microbiome. - Expands the microbiota portions to reflect complexity of diet on gut microbial ecology, metabolism and health

Biomarkers in Nutrition
Biomarkers in Nutrition

Author: Vinood B. Patel

Publisher: Springer Nature

Published: 2022-10-14

Total Pages: 1173

ISBN-13: 3031073894

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This handbook provides an all-inclusive insight into biomarkers assessing the impact of nutrition on human health. The reader will gain insight into the area of circulating body fluid biomarkers, from cardiovascular related markers to liver functional tests. Various biomarkers related to the intake of micronutrient and macronutrients are presented, and the effects of different diets, pesticide exposure and dietary supplements are discussed, so are changes of genetic, cellular and histological variables. This systematic handbook is a must have for biomedical researchers as well as clinicians and pharmacologists, who wish to gain extensive understanding on the analysis of effects of various nutritional and dietary effects on human health, ageing and longevity.

Metabolomics as a Tool in Nutrition Research
Metabolomics as a Tool in Nutrition Research

Author: J-L Sebedio

Publisher: Elsevier

Published: 2014-11-28

Total Pages: 269

ISBN-13: 1782420924

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Metabolomics is a multidisciplinary science used to understand the ways in which nutrients from food are used in the body and how this can be optimised and targeted at specific nutritional needs. Metabolomics as a Tool in Nutrition Research provides a review of the uses of metabolomics in nutritional research. Chapters cover the most important aspects of the topic such as analysis techniques, bioinformatics and integration with other 'omic' sciences such as proteomics and genomics. The final chapters look at the impact of exercise on metabolomic profiles and future trends in metabolomics for nutrition research.

Molecular Basis of Nutrition and Aging
Molecular Basis of Nutrition and Aging

Author: Marco Malavolta

Publisher: Academic Press

Published: 2016-04-15

Total Pages: 786

ISBN-13: 0128018275

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Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. - Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging - Explores how nutritional factors are involved in the pathogenesis of aging across body systems - Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition

Food Fortification in a Globalized World
Food Fortification in a Globalized World

Author: M.G.Venkatesh Mannar

Publisher: Academic Press

Published: 2018-06-29

Total Pages: 415

ISBN-13: 0128028971

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Food Fortification in a Globalized World outlines experiences over the past 50 years—and future potential—for the application of food fortification across a variety of foods in the industrialized and developing world. The book captures recent science and applications trends in fortification, including emerging areas such as biofortification, nutraceuticals and new nutrient intake recommendations, standards, policy and regulation. The book proposes a balanced and effective food fortification strategy for nations to adopt. In covering the most technical scientific details in an approachable style, this work is accessible to a range of practitioners in industry, government, NGOs, academia and research. Food fortification has become an increasingly significant strategy to address gaps in micronutrient intakes in populations with measurable impact in both industrialized and developing countries. While the positive impacts are well recognized there are new concerns in some countries that excessive fortification of foods, outdated nutritional labeling rules and misleading marketing tactics used by food manufacturers may result in young children consuming harmful amounts of some vitamins and minerals. - Presents the latest science on fortification for the prevention of micronutrient deficiencies - Includes emerging areas such as biofortification, nutraceuticals and new nutrient intake recommendations, standards, regulations, practices and policies from around the world - Summarizes evidence of application of food fortification and measured impact on public health - Discusses how public policy impacts fortification of foods and nutritional deficiencies - Considers the complex economics of and market for fortified foods

Antioxidants in Sport Nutrition
Antioxidants in Sport Nutrition

Author: Manfred Lamprecht

Publisher: CRC Press

Published: 2014-09-17

Total Pages: 304

ISBN-13: 1466567570

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The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.

Prevention and Treatment of Cardiovascular Disease
Prevention and Treatment of Cardiovascular Disease

Author: Michael J. Wilkinson

Publisher: Springer Nature

Published: 2021-08-13

Total Pages: 279

ISBN-13: 3030781771

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This book discusses all aspects of non-pharmacologic approaches to primary and secondary CVD prevention. It highlights the strength of evidence for particular diet styles in CVD prevention, including plant-based diets, the Mediterranean diet, the DASH diet, and low-carbohydrate diets. Chapters present evidence and future directions for diet and nutrition in diseases related to CVD, such as dyslipidemia, cardiometabolic disease (pre-diabetes, the metabolic syndrome, type-2 diabetes mellitus), and obesity. Finally, the book reviews novel and emerging aspects of dietary intervention in CVD prevention, such as dietary approaches to inflammation and the role of the microbiome in CVD. Up-to-date, evidence-based, and clinically oriented, Prevention and Treatment of Cardiovascular Disease: Nutritional and Dietary Approaches is an essential resource for physicians, residents, fellows, and medical students in cardiology, clinical nutrition, family medicine, endocrinology, and lipidology.