Chronotherapeutics
Chronotherapeutics

Author: P. H. Redfern

Publisher: Pharmaceutical Press

Published: 2003

Total Pages: 456

ISBN-13: 9780853694885

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In nature, many physical processes are governed by the passage of time. The study of these processes - chronobiology - reveals rhythmic patterns which may be yearly, monthly, daily or more frequent. Novel drug delivery systems are currently being delivered that will release varying quantities of a drug at optimum times to coincide with these rhythmic patterns.Chronotherapeutics considers the pharmaceutical and therapeutic implications associated with biological clocks. The book presents a comprehensive discussion of specific diseases that are time dependent, and the drugs and new drug formulations that can be used as treatments.Written by leading international experts in the field, Chronotherapeutics provides up-to-date information on chronobiology for non-chronobiologists in pharmaceutical and medical sciences. Peter Redfern is Professor of Pharmacology at the University of Bath, UK.

Biological Rhythms
Biological Rhythms

Author: Jurgen Aschoff

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 565

ISBN-13: 1461565529

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Interest in biological rhythms has been traced back more than 2,500]ears to Archilochus, the Greek poet, who in one of his fragments suggests ",,(i,,(VWO'KE o'olos pv{}J.tos txv{}pW7rOVS ~XH" (recognize what rhythm governs man) (Aschoff, 1974). Reference can also be made to the French student of medicine J. J. Virey who, in his thesis of 1814, used for the first time the expression "horloge vivante" (living clock) to describe daily rhythms and to D. C. W. Hufeland (1779) who called the 24-hour period the unit of our natural chronology. However, it was not until the 1930s that real progress was made in the analysis of biological rhythms; and Erwin Bunning was encouraged to publish the first, and still not outdated, monograph in the field in 1958. Two years later, in the middle of exciting discoveries, we took a breather at the Cold Spring Harbor Symposium on Biological Clocks. Its survey on rules considered valid at that time, and Pittendrigh's anticipating view on the temporal organization of living systems, made it a milestone on our way from a more formalistic description of biological rhythms to the understanding of their structural and physiological basis.

Circadian Rhythm Sleep-Wake Disorders
Circadian Rhythm Sleep-Wake Disorders

Author: R. Robert Auger

Publisher: Springer Nature

Published: 2020-05-26

Total Pages: 251

ISBN-13: 3030438031

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This book resolves to bridge the communication gap between research and clinical practice for circadian rhythm sleep-wake disorders. Beginning with a scientific background on biological timekeeping, opening chapters describe the crucial nature of maintaining delicate temporal organization of physiological and molecular events within the body. Following this are discussions on circadian physiology and methods of circadian assessments. Subsequent chapters then relay comprehensive information regarding the International Classification of Sleep Disorders-defined circadian rhythm sleep-wake disorders (CRSWDs), specifically discussing etiology and epidemiology, but focusing on evidence-based treatment data. Concluding discussions provide guidance for the application of light therapy and discuss future roles for optimized lighting environments. Nuanced and market-demanded, Circadian Rhythm Sleep-Wake Disorders: An Evidence-Based Guide for Clinicians and Investigators is an invaluable resource for Sleep Medicine clinicians, circadian researchers, and other interested parties.

Sleep Disorders and Sleep Deprivation
Sleep Disorders and Sleep Deprivation

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2006-10-13

Total Pages: 425

ISBN-13: 0309101115

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Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.

Foundations of Psychiatric Sleep Medicine
Foundations of Psychiatric Sleep Medicine

Author: John W. Winkelman

Publisher: Cambridge University Press

Published: 2010-12-23

Total Pages: 435

ISBN-13: 1139494341

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Sleep-related complaints are extremely common across the spectrum of psychiatric illness. Accurate diagnosis and management of sleep disturbances requires an understanding of the neurobiological mechanisms underlying sleep and wakefulness, the characteristics of sleep disturbance inherent to psychiatric illness and primary sleep disorders, as well as the psychopharmacologic and behavioral treatments available. Foundations of Psychiatric Sleep Medicine provides a uniquely accessible, practical, and expert summary of current clinical concepts at the sleep-psychiatry interface. Topics covered include: basic principles in sleep science, clinical sleep history taking, primary sleep disorders in psychiatric contexts, and sleep disturbance across a range of mood, anxiety, psychotic, substance use, cognitive and developmental disorders. Written by outstanding experts in the field of sleep medicine and psychiatry, this academically rigorous and clinically useful text is an essential resource for psychiatrists, psychologists and other health professionals interested in the relationship between sleep and mental illness.

Functional Somatic Symptoms in Children and Adolescents
Functional Somatic Symptoms in Children and Adolescents

Author: Kasia Kozlowska

Publisher: Springer Nature

Published: 2020-09-30

Total Pages: 397

ISBN-13: 303046184X

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This open access book sets out the stress-system model for functional somatic symptoms in children and adolescents. The book begins by exploring the initial encounter between the paediatrician, child, and family, moves through the assessment process, including the formulation and the treatment contract, and then describes the various forms of treatment that are designed to settle the child’s dysregulated stress system. This approach both provides a new understanding of how such symptoms emerge – typically, through a history of recurrent or chronic stress, either physical or psychological – and points the way to effective assessment, management, and treatment that put the child (and family) back on the road to health and well-being.

The Study of Time II
The Study of Time II

Author: J. T. Fraser

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 492

ISBN-13: 3642501214

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The Second Conference of the International Society for the Study of Time was held at Hotel Mt. Fuji, near Lake Yamanaka, Japan, on July I to 7,1973. The present volume is the proceedings at that Con ference and constitutes the second volume in The Study of Time series. * At the closing session of our First Conference in Oberwolfach, Germany, in 1969, I was honored by being elected to the Presidency of the Society, following Dr. J. G. Whitrow, our fIrst President. My mandate was to organize a Second Conference, consistent with the aim of the Society, which is the holding of interdisciplinary conferences for the presentation and discussion of papers on various as pects of time. Several participants expressed to me their wish to have a second conference held in Japan so as to emphasize the international and intercultural dedication of this Society. Dr. Fraser carefully evaluated this and many other suggestions, weighed the possible conference sites and our chances of raising the necessary funds to convene a meeting at such sites, and concurred with my conclusions that we should go ahead with the plans for a Japanese meeting. For the difficult and complicated task of raising funds and organizing a conference in Japan, I had to select and rely heavily on somebody both capable and reliable and also living in Japan. Thus, I asked the Reverend Michael Mutsuo Yanase, S. J.

The Circadian Clock
The Circadian Clock

Author: Urs Albrecht

Publisher: Springer Science & Business Media

Published: 2010-01-23

Total Pages: 306

ISBN-13: 1441912622

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With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally.