Biochemistry of Antibodies

Biochemistry of Antibodies

Author: R. Nezlin

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 395

ISBN-13: 1468417916

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When the history of immunology in the twentieth century is written, the decade of the 1960's will, in all probability, stand out as the period of greatest advance in the development of molecular immunology. It is appropriate and useful, therefore, that a schol arly and integrated presentation of this progress should be made available in English. The translation of Dr. Nezlin's "Biochem istry of Antibodies" from Russian admirably fulfills this need in the form of a scientific monograph directed to medical and biolog ical scientists. The appearance of this monograph also serves to emphasize the conceptual unification of diverse immunological phenomena which has emerged from progress in molecular immunology. This unity is a consequence of the key role played by the antibody mol ecule (either in solution or cell-bound) in every biological process properly described as immunological. Indeed, immunology as an independent natural science can be described as the study of the structure, interactions, and biosynthes is of the antibody molecule.


Antigen Binding Molecules: Antibodies and T-Cell Receptors

Antigen Binding Molecules: Antibodies and T-Cell Receptors

Author:

Publisher: Academic Press

Published: 1996-12-13

Total Pages: 561

ISBN-13: 0080582222

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Topics Covered Include: X-ray crystallography of ligands. Catalytic antibodies. Nature of the antigen. Antibody binding sites. Maturation of the immune response. Computational biochemistry of antibodies and T-cell receptors. Antigen-specific T-cell receptors and their reactions. Key Features* X-Ray Crystallography of Ligands* Catalytic Antibodies* Nature of the Antigen* Antibody Binding Sites* Maturtion of the Immune Response* Computational Biochemistry of Antibodies and * T-Cell Receptors* Antigen-Specific T-Cell Receptors and Their Reactions


Enzyme Immunoassays

Enzyme Immunoassays

Author: S.S. Deshpande

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 473

ISBN-13: 1461311691

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This unique reference provides a pragmatic approach to the development of successful commercial immunodiagnostic products based on enzyme immunoessay technology. Presenting both the basic and applied principles, Enzyme Immunoassays gathers information on all aspects of this process, from the initial conceptualization to the introduction of the product to the market.


Catalytic Antibodies

Catalytic Antibodies

Author: Derek J. Chadwick

Publisher: John Wiley & Sons

Published: 2008-04-30

Total Pages: 270

ISBN-13: 0470514116

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Contains the presentations and discussions that took place during a symposium at the CIBA Foundation on October 1-3, 1990 on the subject of catalytic antibodies. The recognition that monoclonal antibodies can possess catalytic activity is a recent advance with profound ramifications for chemistry. In addition to their potential commercial applications as catalysts for reactions, for which there are no known enzymes, antibodies promise to provide valuable insight into the detailed mechanisms of biological catalysis and organic chemistry.


Monoclonal Antibodies

Monoclonal Antibodies

Author: James W. Goding

Publisher:

Published: 1986

Total Pages: 344

ISBN-13:

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This book represents the distillation and critical evaluation of many hundreds of publications relating to the production and use of antibodies. Therefore it is restricted to the "core" techniques of production and handling of antibodies, and their use in studies of antigen analysis, purification and localization.


Applied Immunology and Biochemistry

Applied Immunology and Biochemistry

Author: Taylor Barker

Publisher: Scientific e-Resources

Published: 2019-09-07

Total Pages: 344

ISBN-13: 1839471700

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Immunology is a fast evolving subject, and attempt has been made in this work to keep it as much up-to-date as possible according to the requirement of the students and researchers in the field. Immunology is the study of how the body defends itself against disease. It helps us understand how the immune system is tricked into attacking its own tissue, leading to diseases like rheumatoid arthritis, diabetes or allergy. Immunodeficiency disorders involve malfunction of the immune system, resulting in infections that develop and recur more frequently, are more severe, and last longer than usual. Biochemistry is the study of how cells work at molecular level. Biochemistry, and the related field of molecular biology, are important in understanding the molecular basis of life and its role in the disease process. Biochemistry is the investigation of the molecular basis of life. Throughout the history of this scientific discipline, biochemists have worked to reveal the fundamental chemical and physical principles that underlie living processes, their success is demonstrated in the enormous impact that the biochemical approach has had on the life sciences. This book reviews the principles of immunology and biochemistry, provides basic concepts of it by extracting the important information on immunology and peasants it in a concise, uncluttered fashion to prepare students for their courses.


Basic Methods in Antibody Production and Characterization

Basic Methods in Antibody Production and Characterization

Author: Gary C. Howard

Publisher: CRC Press

Published: 2000-09-21

Total Pages: 286

ISBN-13: 142003653X

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Written for researchers and professionals in the fields of biomedical research, immunology, biochemistry, molecular biology, pathology, and biotechnology, Basic Methods in Antibody Production and Characterization uses a cookbook approach to presenting the methods for the production, characterization, and use of antibodies. Antibodies described


The Antigens

The Antigens

Author: Michael Sela

Publisher: Academic Press

Published: 2014-05-10

Total Pages: 588

ISBN-13: 1483269892

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The Antigens, Volume I is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology, structure and function, their initiation of the immune response, and the nature of the products of this response. The nature of the reaction of antigens with antibodies and with sensitized cells is also explored. Comprised of seven chapters, this volume begins with a discussion on the antigenic functions of nucleic acids as well as their immunogenicity, hapten functions, and serologic reactions. The reader is then introduced to the immunochemistry and antigenic determinants of enzymes, along with the structure and phylogeny of immunoglobulins and immunoglobulin allotypes. The evolution of proteins and their structure and function is also considered, paying particular attention to evolution by the random fixation of selectively neutral alleles, the rates of protein evolution, gene duplication, and divergence or convergence. The final chapter is devoted to the chemistry and biology of immunoglobulin E as well as the regulation of formation of their antibodies. This book will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.


Introduction to Antibody Engineering

Introduction to Antibody Engineering

Author: Florian Rüker

Publisher: Springer Nature

Published: 2021-01-04

Total Pages: 388

ISBN-13: 3030546306

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This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master’s and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.