A comprehensive primer and reference, this book provides pharmacists and health practitioners the relevant science and policy concepts behind biologics, biosimilars, and biobetters from a practical and clinical perspective. Explains what pharmacists need to discuss the equivalence, efficacy, safety, and risks of biosimilars with physicians, health practitioners, and patients about Guides regulators on pragmatic approaches to dealing with these drugs in the context of rapidly evolving scientific and clinical evidence Balances scientific information on complex drugs with practical information, such as a checklist for pharmacists
Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markersâ€"indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive abilityâ€"are a promising tool for research aimed at answering that important question. Biologic Markers in Reproductive Toxicology examines the potential of these markers in environmental health studies; clarifies definitions, underlying concepts, and possible applications; and shows the benefits to be gained from their use in reproductive and neurodevelopmental research.
Written by leading experts in the field and designed for dermatologists and residents, this book includes evidence-based medicine that underscores the clinical data, as well as practical tips on how to use both biologic and systemic agents in the field of dermatology. In the past decade, there have been several groundbreaking advances in medical dermatology. Novel biologic and systemic agents have been developed to treat inflammatory disorders, including psoriasis and atopic dermatitis, as well as skin malignancies such as melanoma. Biologic and Systemic Agents in Dermatology encompasses these developments by describing the mechanism of action of these various agents and the clinical efficacy and safety to treating these respective disorders. The utilization of biologic and systemic agents in other dermatologic conditions, pharmacoeconomics, pharmacovigilance, and clinical trials outcomes are discussed as well as topics including tumor necrosis, conventional systemic agents for psoriatic disease, and oral agents for atopic dermatitis.
A biography of the physician and health guru, examining his views on science and medicine as he evolved religiously. Purveyors of spiritualized medicine have been legion in American religious history, but few have achieved the superstar status of Dr. John Harvey Kellogg and his Battle Creek Sanitarium. In its heyday, the “San” was a combination spa and Mayo Clinic. Founded in 1866 under the auspices of the Seventh-day Adventist Church and presided over by the charismatic Dr. Kellogg, it catered to many well-heeled health seekers including Henry Ford, John D. Rockefeller, and Presidents Taft and Harding. It also supported a hospital, research facilities, a medical school, a nursing school, several health food companies, and a publishing house dedicated to producing materials on health and wellness. Rather than focusing on Kellogg as the eccentric creator of corn flakes or a megalomaniacal quack, Brian C. Wilson takes his role as a physician and a theological innovator seriously and places his religion of “Biologic Living” in an on-going tradition of sacred health and wellness. With the fascinating and unlikely story of the “San” as a backdrop, Wilson traces the development of this theology of physiology from its roots in antebellum health reform and Seventh-day Adventism to its ultimate accommodation of genetics and eugenics in the Progressive Era. “A well-researched biography that seeks to restore the reputation of the doctor satirized in T. C. Boyle’s novel The Road to Wellville and in the film of the same name. Wilson has done much more than provide a sympathetic biography of the man who headed the once-famous Battle Creek Sanitarium. . . . There’s much here to interest both adherents to and skeptics of today’s alternative and holistic medicines, as well as fans of American history, especially the history of religions.” —Kirkus Reviews “While he may look like a certain Kentucky Fried Colonel, Kellogg was an early advocate of a vegan diet and the intriguing figure behind the famous Battle Creek Sanitarium that paved the way for many contemporary ideas of holistic health and wellness. . . . Wilson’s lively and accessible writing introduces readers to spiritualism, millennialism, the temperance and social purity movements, Swedenborgians, and Mormons. . . . [A] thought-provoking portrait of a charismatic, intelligent medical doctor who never stopped absorbing new information and honing his theories, even when he was faced with disfellowship from his church and ostracism by friends and colleagues.” —ForeWord Reviews “Wilson does an admirable job of portraying how the doctor’s beliefs shifted and adapted over time. . . . Readers with a keen interest in religious history, particularly as it relates to health care, will enjoy this biography the most.” —Library Journal
Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.
Biologic Regulation of Physical Activity provides readers with a cutting-edge perspective of underlying issues that may contribute to the obesity epidemic. It offers evidence of a biologic regulator affecting physical activity and explores implications of such biologic control on activity.
