Basal ganglia: physiological, behavioral, and computational studies
Basal ganglia: physiological, behavioral, and computational studies

Author: Ahmed A. Moustafa

Publisher: Frontiers Media SA

Published: 2015-05-26

Total Pages: 495

ISBN-13: 2889193888

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The basal ganglia has received much attention over the last two decades, as it has been implicated in many neurological and psychiatric disorders. Most of this research—in both animals and humans—attempt to understand the neural and biochemical substrates of basic motor and learning processes, and how these are affected in human patients as well as animal models of brain disorders. The current volume contains research articles and reviews describing basic, pre-clinical and clinical neuroscience research of the basal ganglia written by attendees of the 11th Triennial Meeting of the International Basal Ganglia Society (IBAGS) that was held March 3-7th, 2013 at the Princess Hotel, Eilat, Israel and by researchers of the basal ganglia. Specifically, articles in this volume include research reports on the biochemistry, computational theory, anatomy and physiology of single neurons and functional circuitry of the basal ganglia networks as well as the latest data on animal models of basal ganglia dysfunction and clinical studies in human patients.

The Hidden Life of the Basal Ganglia
The Hidden Life of the Basal Ganglia

Author: Hagai Bergman

Publisher: MIT Press

Published: 2021-10-12

Total Pages: 333

ISBN-13: 0262367297

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The anatomy and physiology of the basal ganglia and their relation to brain and behavior, disorders and therapies, and philosophy of mind and moral values. The main task of the basal ganglia—a group of subcortical nuclei, located at the base of the brain—is to optimize and execute our automatic behavior. In this book, Hagai Bergman analyzes the anatomy and physiology of the basal ganglia, discussing their relation to brain and behavior, to disorders and therapies, and even to moral values. Drawing on his forty years of studying the basal ganglia, Bergman presents new information on physiology and computational models, Parkinson’s disease and other ganglia-related disorders, and such therapies as deep brain stimulation. Focusing on studies of nonhuman primates and human basal ganglia and relying on system physiology and in vivo extra-cellular recording techniques, Bergman first describes the major brain structures that constitute the basal ganglia, the morphology of their cellular elements, their synaptic connectivity and their physiological function in health and disease. He discusses the computational physiology of the healthy basal ganglia, describing four generations of computational models, and then traces the computational physiology of basal ganglia–related disorders and their treatments, including Parkinson’s disease and its pharmacological and surgical therapies. Finally, Bergman considers the implications of these findings for such moral concerns as free will. Explaining this leap into domains rarely explored in neuroscientific accounts, Bergman writes that the longer he studies the basal ganglia, the more he is convinced that they are truly the base of both brain and mind.

Movement Disorders Curricula
Movement Disorders Curricula

Author: Cristian Falup-Pecurariu

Publisher: Springer

Published: 2017-02-27

Total Pages: 444

ISBN-13: 3709116287

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This book offers a comprehensive approach to the wide range of movement disorders, an important specialty in the field of neurology, guiding readers from the phenomenology to diagnosis and management. Reflecting the latest developments in the field, it offers a unique summary of this dynamic area by pursuing a uniform approach to movement disorders curricula. Divided into three parts, Movement Disorders Curricula provides an authoritative overview of this growing branch of neurology. The first part presents the basic elements of movement disorders, including descriptions of the anatomy and physiology of the basal ganglia. It also features sections on clinical trials for movement disorders, practical skills, and rating scales. The second and third part examine in detail hypokinetic and hyperkinetic movement disorders, respectively. Equipping readers with the practical and research skills needed in the movement disorders field, the book offers a valuable tool to help them prepare for board examinations on general neurology, as well as for fellowships in movement disorders.

Neurobiology of Decision-Making
Neurobiology of Decision-Making

Author: Antonio R. Damasio

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 215

ISBN-13: 3642799280

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Neuroscience has paid only little attention to decision-making for many years. Although no field of science has cohered around this topic, a variety of researchers in different areas of neuroscience ranging from cellular physiology to neuropsychology and computational neuroscience have been engaged in working on this issue. Thus, the time seemed to be ripe to bring these researchers together and discuss the state of the art of the neurobiology of decision-making in a broad forum. This book is a collection of contributions presented at that forum in Paris in October 1994 organized by the Fondation IPSEN.

Models of Information Processing in the Basal Ganglia
Models of Information Processing in the Basal Ganglia

Author: James C. Houk

Publisher: MIT Press

Published: 1995

Total Pages: 414

ISBN-13: 9780262082341

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This book brings together the biology and computational features of the basal ganglia and their related cortical areas along with select examples of how this knowledge can be integrated into neural network models. Recent years have seen a remarkable expansion of knowledge about the anatomical organization of the part of the brain known as the basal ganglia, the signal processing that occurs in these structures, and the many relations both to molecular mechanisms and to cognitive functions. This book brings together the biology and computational features of the basal ganglia and their related cortical areas along with select examples of how this knowledge can be integrated into neural network models. Organized in four parts - fundamentals, motor functions and working memories, reward mechanisms, and cognitive and memory operations - the chapters present a unique admixture of theory, cognitive psychology, anatomy, and both cellular- and systems- level physiology written by experts in each of these areas. The editors have provided commentaries as a helpful guide to each part. Many new discoveries about the biology of the basal ganglia are summarized, and their impact on the computational role of the forebrain in the planning and control of complex motor behaviors discussed. The various findings point toward an unexpected role for the basal ganglia in the contextual analysis of the environment and in the adaptive use of this information for the planning and execution of intelligent behaviors. Parallels are explored between these findings and new connectionist approaches to difficult control problems in robotics and engineering. Contributors James L. Adams, P. Apicella, Michael Arbib, Dana H. Ballard, Andrew G. Barto, J. Brian Burns, Christopher I. Connolly, Peter F. Dominey, Richard P. Dum, John Gabrieli, M. Garcia-Munoz, Patricia S. Goldman-Rakic, Ann M. Graybiel, P. M. Groves, Mary M. Hayhoe, J. R. Hollerman, George Houghton, James C. Houk, Stephen Jackson, Minoru Kimura, A. B. Kirillov, Rolf Kotter, J. C. Linder, T. Ljungberg, M. S. Manley, M. E. Martone, J. Mirenowicz, C. D. Myre, Jeff Pelz, Nathalie Picard, R. Romo, S. F. Sawyer, E Scarnat, Wolfram Schultz, Peter L. Strick, Charles J. Wilson, Jeff Wickens, Donald J. Woodward, S. J. Young

Marsden's Book of Movement Disorders
Marsden's Book of Movement Disorders

Author: Ivan Donaldson

Publisher: Oxford University Press

Published: 2012-03-29

Total Pages: 1512

ISBN-13: 0191502243

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This book represents the final work of the late Professor C. David Marsden, who was the most influential figure in the field of movement disorders, in terms of his contributions to both research and clinical practice, in the modern era. It was conceived and written by David Marsden and his colleague at the Institute of Neurology, Prof. Ivan Donaldson. It was their intention that this would be the most comprehensive book on movement disorders and also that it would serve as the 'clinical Bible' for the management of these conditions. It provides a masterly survey of the entire topic, which has been made possible only by vast laboratory and bedside experience. Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to rare, and very rare conditions such as Niemann-Pick disease. Chapters follow a structured format with historical overviews, definitions, clinical features, differential diagnosis, investigations and treatment covered in a structured way. It is extensively illustrated with many original photographs and diagrams of historical significance. Among these illustrations are still images of some original film clips of some of Dr. Marsden's patients published here for the first time. Comprehensively referenced and updated by experts from the Institute of Neurology at Queen Square, this book is a valuable reference for, not just movement disorder specialists and researchers, but also for clinicians who care for patients with movement disorders.

Timing of Behavior
Timing of Behavior

Author: David A. Rosenbaum

Publisher: MIT Press

Published: 1998

Total Pages: 402

ISBN-13: 9780262181884

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This volume presents cutting-edge research on the production, perception, and memory of timed events. Athletes and musicians demonstrate the levels to which humans can ascend in the timing of behavior. But even common actions, such as opening a door or bringing a cup to one's lips, reveal how we organize our behavior temporally. When there is damage to the nervous system and the ability to time behavior breaks down, we become aware of how many things must go right for timing not to go terribly wrong. In recent years, there has been a considerable growth of interest among cognitive and brain scientists in the timing aspects of human behavior. This volume presents cutting-edge research on the production, perception, and memory of timed events. Empirical chapters discuss a variety of tasks ranging from locomotion to finger-tapping. Theoretical chapters provide quantitative models for topics as diverse as eyeblink conditioning and posture during walking. Other chapters discuss the neuroanatomical bases of timing behavior. Contributors: Lorraine G. Allan, Eric L. Amazeen, Polemnia G. Amazeen, Heather Jane Barnes, Steven Boker, Darlene H. Brunzell, June-Seek Choi, Russell M. Church, Charles E. Collyer, Christopher Connolly, Frederick J. Diedrich, John Gibbon, Roderic Grupen, Kathleen Y. Haaland, Deborah L. Harrington, Kjeldy Haugsjaa, Kenneth G. Holt, John J. Jeka, Bruce A. Kay, Michael Kubovy, Tiffany Mattson, Warren Meck, John W. Moore, Trevor Penney, Bruno H. Repp, David A. Rosenbaum, Kamal Souccar, Michael T. Turvey, Jonathan Vaughan, William H. Warren, Jr.

Goal-Directed Decision Making
Goal-Directed Decision Making

Author: Richard W. Morris

Publisher: Academic Press

Published: 2018-08-23

Total Pages: 486

ISBN-13: 0128120991

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Goal-Directed Decision Making: Computations and Neural Circuits examines the role of goal-directed choice. It begins with an examination of the computations performed by associated circuits, but then moves on to in-depth examinations on how goal-directed learning interacts with other forms of choice and response selection. This is the only book that embraces the multidisciplinary nature of this area of decision-making, integrating our knowledge of goal-directed decision-making from basic, computational, clinical, and ethology research into a single resource that is invaluable for neuroscientists, psychologists and computer scientists alike. The book presents discussions on the broader field of decision-making and how it has expanded to incorporate ideas related to flexible behaviors, such as cognitive control, economic choice, and Bayesian inference, as well as the influences that motivation, context and cues have on behavior and decision-making. - Details the neural circuits functionally involved in goal-directed decision-making and the computations these circuits perform - Discusses changes in goal-directed decision-making spurred by development and disorders, and within real-world applications, including social contexts and addiction - Synthesizes neuroscience, psychology and computer science research to offer a unique perspective on the central and emerging issues in goal-directed decision-making

Advances in Brain Inspired Cognitive Systems
Advances in Brain Inspired Cognitive Systems

Author: Cheng-Lin Liu

Publisher: Springer

Published: 2016-11-11

Total Pages: 379

ISBN-13: 3319496859

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This book constitutes the refereed proceedings of the 8th International Conference on Brain Inspired Cognitive Systems, BICS 2016, held in Beijing, China, in November 2016. The 32 full papers presented were carefully reviewed and selected from 43 submissions. They discuss the emerging areas and challenges, present the state of the art of brain-inspired cognitive systems research and applications in diverse fields by covering many topics in brain inspired cognitive systems related research including biologically inspired systems, cognitive neuroscience, models consciousness, and neural computation.

Computational Models of Brain and Behavior
Computational Models of Brain and Behavior

Author: Ahmed A. Moustafa

Publisher: John Wiley & Sons

Published: 2017-09-11

Total Pages: 588

ISBN-13: 1119159075

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A comprehensive Introduction to the world of brain and behavior computational models This book provides a broad collection of articles covering different aspects of computational modeling efforts in psychology and neuroscience. Specifically, it discusses models that span different brain regions (hippocampus, amygdala, basal ganglia, visual cortex), different species (humans, rats, fruit flies), and different modeling methods (neural network, Bayesian, reinforcement learning, data fitting, and Hodgkin-Huxley models, among others). Computational Models of Brain and Behavior is divided into four sections: (a) Models of brain disorders; (b) Neural models of behavioral processes; (c) Models of neural processes, brain regions and neurotransmitters, and (d) Neural modeling approaches. It provides in-depth coverage of models of psychiatric disorders, including depression, posttraumatic stress disorder (PTSD), schizophrenia, and dyslexia; models of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy; early sensory and perceptual processes; models of olfaction; higher/systems level models and low-level models; Pavlovian and instrumental conditioning; linking information theory to neurobiology; and more. Covers computational approximations to intellectual disability in down syndrome Discusses computational models of pharmacological and immunological treatment in Alzheimer's disease Examines neural circuit models of serotonergic system (from microcircuits to cognition) Educates on information theory, memory, prediction, and timing in associative learning Computational Models of Brain and Behavior is written for advanced undergraduate, Master's and PhD-level students—as well as researchers involved in computational neuroscience modeling research.