ATP-gated Cation Channels (P2X Receptors) in the Central Peripheral Nervous System
Author: Lyudmila Vulchanova
Publisher:
Published: 1998
Total Pages: 244
ISBN-13:
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Author: Lyudmila Vulchanova
Publisher:
Published: 1998
Total Pages: 244
ISBN-13:
DOWNLOAD EBOOKAuthor: Andrea Nistri
Publisher: Frontiers Media SA
Published: 2015-01-05
Total Pages: 173
ISBN-13: 2889194051
DOWNLOAD EBOOKExtracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research field is rapidly growing, as evidenced by the almost 2000 papers published in the last 5 years. However, despite the fundamental signalling function of extracellular ATP in the nervous system, the widespread roles of P2X receptors have not been widely elucidated and presented in textbooks. In this volume of papers we aim to gather a collection of high quality papers, detailing the latest insights from the most accomplished international P2X receptor researchers. Importantly, basic research into P2X receptors has a strong translational impact and our collection of articles could be a valuable guide for the development of new pharmacological and biotechnological tools addressing the function of P2X receptors. Within this collection we plan to cover receptor structure-function relationships, receptors trafficking, to highlight the special properties of P2X receptors and their pharmacological profiles, and to describe the translational aspects of cellular ATP signaling in pain and in other neurological and vascular diseases.
Author: Dima Alkawwas Decker
Publisher:
Published: 2009
Total Pages: 270
ISBN-13:
DOWNLOAD EBOOKAuthor: Abel Lajtha
Publisher:
Published: 1982
Total Pages:
ISBN-13:
DOWNLOAD EBOOKAuthor: Refik Kanjhan
Publisher:
Published: 2001
Total Pages: 1124
ISBN-13:
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Publisher: Academic Press
Published: 2011-07-13
Total Pages: 558
ISBN-13: 0123855330
DOWNLOAD EBOOKThis is an overview of the fast-moving field of purinergic signalling through adenosine and ATP receptors. Authors are the leading authorities in their fields Subject matter is important for understanding tissue protection Subject matter is of intense interest for new drug development
Author: Constance N. Wilson
Publisher: Springer Science & Business Media
Published: 2009-07-28
Total Pages: 656
ISBN-13: 3540896155
DOWNLOAD EBOOKSince their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.
Author: Robson Faria
Publisher: BoD – Books on Demand
Published: 2020-03-11
Total Pages: 112
ISBN-13: 1789845343
DOWNLOAD EBOOKThis book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.
Author: Brendan J. Canning
Publisher: Springer Science & Business Media
Published: 2009-08-05
Total Pages: 623
ISBN-13: 354079090X
DOWNLOAD EBOOKThe intention of this book is to provide a comprehensive and contemporary review of the biology of sensory nerves. The book is unique, as it comprehensively covers the role of sensory nerves across many therapeutic areas.
Author: Ralph W. Straub
Publisher:
Published: 1978
Total Pages: 392
ISBN-13:
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