The rat is probably the most widely used experimental system in neurobiology. Several anatomical atlases of the rat's nervous system already exist, but this atlas is unique in that it maps the distribution of all neuroactive substances--transmitters, growth factors, modulators, hormones, and peptides--and their receptors by brain region. It begins with a useful overview of neurotransmission mechanisms. The entire brain is then presented in highly visual three-color sections. The atlas covers the synthesis, distribution, and functions of each class of substances in intricate detail. The authors follow this with an analysis of the structure, subtypes, and distribution of receptors. The volume will be an invaluable reference work for all researchers in neuropharmacology, neurobiology, and neuropathology.
A Textbook of Biological Psychiatry integrates the basic science concerning brain mechanisms of psychiatric disorders alongside surveys of present standard clinical treatment. Organized in a coherent and easy to follow structure, chapters expand across different levels of analysis, from basic mechanisms to clinical practice. This comprehensive reference provides an integrative treatment of the biochemistry of neurotransmission, behavioral pharmacology, and clinical aspects of psychiatric problems including depression, manic-depression, and mood disorders. Other chapters address the biological mechanisms and treatment of depression, anxiety, panic, obsessive-compulsive disorder, and addictions. The editor concludes with a perspective on the future of the field and prospects for understanding and effectively treating mood and anxiety disorders.
Like previous handbooks, the present volume is an authoritative and up-to-date compendium of information and perspective on the neurobiology of ingestive behaviors. It is intended to be stimulating and informative to the practitioner, whether neophyte or senior scholar. It is also intended to be accessible to others who do not investigate the biological bases of food and ?uid ingestion, who may teach aspects of this material or simply wonder about the current state of the ?eld. To all readers, we present this handbook as a progress report, recognizing that the present state of the ?eld is much farther along than it was the last time a handbook was published, but mindful of the likelihood that it is not as far along as it will be when the next handbook is prepared. This ?eld has witnessed a spectacular accretion of scienti?c information since the ?rst handbook was published in 1967. During the generation of science between then and the publication of the second handbook in 1990, numerous scienti?c reports have substantially changed the perspective and informational base of the ?eld.
This book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology – including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).
Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader’s knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 3 addresses prescription medications, caffeine, polydrug misuse, and non-drug addictions. Each section provides data on the general, molecular, cellular, structural, and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad of material and substances. Offers a modern approach to understanding the pathology of substances of abuse, offering an evidence-based ethos for understanding the neurology of addictions Fills an existing gap in the literature by serving as a “one-stop-shopping” synopsis of everything to do with the neuropathology of drugs of addiction and substance misuse Includes in each chapter: list of abbreviations, abstract, introduction, applications to other addictions and substance misuse, mini-dictionary of terms, summary points, 6+ figures and tables, full references Offers coverage of preclinical, clinical, and population studies, from the cell to whole organs, and from the genome to whole body
Identification of Neural Markers Accompanying Memory is a fresh and novel volume of memory study, providing up-to-date and comprehensive information for both students and researchers focused on the identification of neural markers accompanying memory. Contributions by experts in specific areas of memory study provide background on and definitions of memory, memory alterations, and the brain areas involved in memory and its related processes, such as consolidation, retrieval, forgetting, amnesia, and antiamnesiac effects. With coverage of the principal neurotransmitters related to memory, brain disorders presenting memory alterations, and available treatments—and with discussion of neural markers as new targets for the treatment of memory alterations—Identification of Neural Markers Accompanying Memory is a necessary and timely work for researchers in this growing field. Discusses the alterations of memory in diverse diseases Includes coverage from a basic introduction of memory investigation Reviews brain areas and neurotransmitters involved in memory Discusses behavioral models of memory Contains novel insights into the complexity of signaling and memory Includes the neuropharmacological and neurobiological bases of memory
Pain is an emotion experienced in the brain, it is not like touch, taste, sight, smell or hearing. It is categorised into Acute Pain less than twelve weeks duration and Chronic Pain if over twelve weeks. Pain can be perceived as a warning of potential damage, but can also be present when no actual harm is being done to the body. This book examines new research into the causes, symptoms and treatments of pain.
Some investigators have argued that emotions, especially animal emotions, are illusory concepts outside the realm of scientific inquiry. However, with advances in neurobiology and neuroscience, researchers are demonstrating that this position is wrong as they move closer to a lasting understanding of the biology and psychology of emotion. In Affective Neuroscience, Jaak Panksepp provides the most up-to-date information about the brain-operating systems that organize the fundamental emotional tendencies of all mammals. Presenting complex material in a readable manner, the book offers a comprehensive summary of the fundamental neural sources of human and animal feelings, as well as a conceptual framework for studying emotional systems of the brain. Panksepp approaches emotions from the perspective of basic emotion theory but does not fail to address the complex issues raised by constructionist approaches. These issues include relations to human consciousness and the psychiatric implications of this knowledge. The book includes chapters on sleep and arousal, pleasure and fear systems, the sources of rage and anger, and the neural control of sexuality, as well as the more subtle emotions related to maternal care, social loss, and playfulness. Representing a synthetic integration of vast amounts of neurobehavioral knowledge, including relevant neuroanatomy, neurophysiology, and neurochemistry, this book will be one of the most important contributions to understanding the biology of emotions since Darwins The Expression of the Emotions in Man and Animals
When an excessive proportion of the human energy requirement is derived from fat, the likelihood of obesity increases. Any such individual is at risk for diabetes and cardiovascular disease- grave and costly health hazards. The selective control of fat ingestion is a promising solution to these concerns. Existing data suggests that macronutrient intake can be manipulated. Further research is working to create pharmacological tools that will suppress fat consumption. It will also be possible to fight obesity, heart disease and diabetes. Neural and Metabolic Control of Macronutrient Intake systematically discusses the known physiological mechanisms involved in macronutrientselection, including their molecular, genetic and neurochemical aspects. The book is also a critical review of the hypothesis that ingestion of the three nutrients is regulated by separate neural control mechanisms, leaving open the possibility that strategies could be devised to intervene in bodily control systems and alter the proportion of fat in the diet. This reference provides three types of information: First, the basic background of the biochemical and physiological systems as they relate to macronutrient selection. Second, opinions and data concerning to what degree animals and humans show evidence of macronutrient selection. And, third, evidence about how the central nervous system might be involved in the choices animals make among macronutrients.
