Atherosclerosis: Diet and Drugs
Atherosclerosis: Diet and Drugs

Author: Arnold Eckardstein

Publisher: Springer Science & Business Media

Published: 2005-11-02

Total Pages: 808

ISBN-13: 3540276610

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Cardiovascular diseases continue to be the leading cause of death in the - jority of industrialized countries. The most frequent underlying pathology, namely atherosclerosis, and its clinical sequelae, namely coronary heart d- ease, cerebrovascular disease and peripheral artery disease, remain common although for a long time we have been made aware of avoidable or mo- ?able etiological factors such as smoking, fat-rich diet or lack of exercise, and although these adverse lifestyle factors have been extensively addressed by population-wide primary prevention programs. Cardiovascular morbidity and mortality also remain high despite successful anti-hypertensive and lipid lowering drug therapies which help to reduce cardiovascular morbidity and mortality by about 30% in both secondary and tertiary prevention settings. This can partly be explained by the increasing life expectancy and growing p- portionofelderly people,especiallyinEuropeandNorthAmerica. Inaddition, the World Health Organization makes the alarming prediction that probably in response to the spreading of western dietary behavior and lack of exercise resulting in an increasing prevalence of diabetes, dyslipidemia and hypert- sion, cardiovascular diseases rather than infectious diseases will become the most frequent cause of death worldwide. This volume of the Handbook of Experimental Pharmacology entitled “Atherosclerosis” is divided into four parts and intends to give an overview on the pathogenesis of atherosclerosis, established treatment and prevention regimen, and of perspectives for the development of new treatment modalities.

Atherosclerosis: Diet and Drugs
Atherosclerosis: Diet and Drugs

Author: Arnold von Eckardstein

Publisher: Springer

Published: 2010-11-16

Total Pages: 816

ISBN-13: 9783540802969

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Cardiovascular diseases continue to be the leading cause of death in the - jority of industrialized countries. The most frequent underlying pathology, namely atherosclerosis, and its clinical sequelae, namely coronary heart d- ease, cerebrovascular disease and peripheral artery disease, remain common although for a long time we have been made aware of avoidable or mo- ?able etiological factors such as smoking, fat-rich diet or lack of exercise, and although these adverse lifestyle factors have been extensively addressed by population-wide primary prevention programs. Cardiovascular morbidity and mortality also remain high despite successful anti-hypertensive and lipid lowering drug therapies which help to reduce cardiovascular morbidity and mortality by about 30% in both secondary and tertiary prevention settings. This can partly be explained by the increasing life expectancy and growing p- portionofelderly people,especiallyinEuropeandNorthAmerica. Inaddition, the World Health Organization makes the alarming prediction that probably in response to the spreading of western dietary behavior and lack of exercise resulting in an increasing prevalence of diabetes, dyslipidemia and hypert- sion, cardiovascular diseases rather than infectious diseases will become the most frequent cause of death worldwide. This volume of the Handbook of Experimental Pharmacology entitled “Atherosclerosis” is divided into four parts and intends to give an overview on the pathogenesis of atherosclerosis, established treatment and prevention regimen, and of perspectives for the development of new treatment modalities.

Prevention and Treatment of Atherosclerosis
Prevention and Treatment of Atherosclerosis

Author: Arnold von Eckardstein

Publisher: Springer Nature

Published: 2022

Total Pages: 537

ISBN-13: 3030860760

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This open access book is supported by the European Atherosclerosis Society Association (EAS). This follow-up edition of the well-received Handbook volume 'Atherosclerosis: Diet and Drugs' reflects the state-of-the-art and most recent developments in atherosclerosis research. Outstanding international experts give a comprehensive overview of the field covering topics, such as improving the treatment focusing on established targets, novel drug developments addressing pre-defined targets, hypothesis-based and hypothesis-free approaches to unravel novel targets.

Diet and Atherosclerosis
Diet and Atherosclerosis

Author: Cesare Sirtori

Publisher: Springer

Published: 1975-07

Total Pages: 280

ISBN-13:

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After the success of the two previous meetings on Typing of Hyperlipoproteinemias, in Milan in 1971 and in Rome in 1972, an important part of each of which was devoted to the discussion of therapy, the Italian Society for the Study of Atherosclerosis, the Institute Superiore di Sanita, and the Fondazione Giovanni Lorenzini planned a special treatment of this important topic. This meeting was held in Rome in November 1973 at the Istituto Superiore di Sanita. On this occasion the most important subjects developed in recent years by the most qualified centers of experimental and clinical research were reported. A broad discussion took place regarding the role of diet in causing or worsening the biohumoral changes and the lesions peculiar to arteriosclerosis, while other distinguished authors reported on the role of diet in delaying or correcting the dyslipidemic state.

Atherosclerosis Drug Discovery
Atherosclerosis Drug Discovery

Author: Charles Day

Publisher: Springer Science & Business Media

Published: 2013-11-22

Total Pages: 456

ISBN-13: 146144618X

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Although atherosclerosis is the leading cause of death in the so-called affluent societies, there is presently no drug in our pharmacologic armamentarium against disease to either prevent or reverse this insidious killer and debilitant of human lives. Because of this void the First Brook Lodge Symposium on Anti Atherosclerosis Drug Discovery was convened at Brook Lodge in Augusta, Michigan, August 13-15, 1975. The symposium was sponsored by The Upjohn Company and was international in scope, with investi gators attending from such countries as England, Japan, Belgium, and Italy. The symposium focused on the problems associated with the discovery and evaluation of new drugs effective in preventing or reversing atherosclerosis. The thrust of material is centered around animal models useful as tools in the search and evaluation of new drugs. Broadly categorized, the models are nonhuman primates, rabbits, rodents, quail, and tissue culture. The material is a mix of studies on serum lipids and, more importantly, of studies on the artery, irrespective of serum lipid levels. The prevention of arterial lesions, not reduction of serum lipids, is emphasized. A review of all anti-atherosclerotic agents, with the exception of hypolipidemic agents, is included in this volume of the proceedings of the symposium.

Drugs, Lipid Metabolism, and Atherosclerosis
Drugs, Lipid Metabolism, and Atherosclerosis

Author: David Kritchevsky

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 433

ISBN-13: 1468409670

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This volume comprises the proceedings of the sixth International Symposium on Drugs Affecting Lipid Meta bolism. Since the first of these symposia in 1960 these triennial meetings have been devoted to the exploration of new ideas, new data and new concepts related to lipid metabolism and atherosclerosis. The sixth Meeting was particularly stimulating in this regard. The concept of the "protective" action of HDL was thoroughly explored within the framework of its molecular biology with data on its epidemiological as well as its in vitro mechan ism(s) of action being discussed. The action of drugs on arterial and HDL metabolism was also discussed as were newer aspects of platelet aggregation, especially as related to prostaglandins. New ground was also broken in discussions of lipid mobilization and mechan isms of hypocholesteremia. We are indebted to the many organizations who con tributed generously to the support of this meeting. Among the sponsors, the assistance of the Lorenzini Foundation was especially helpful. As in all meetings of this type, the hard work of the local organizing committee was instrumental in its success. We are grateful to Mrs. Caroline Hyatt and Mr. Ralph Hollerorth for their invaluable help in the secretariat. We are also deeply indebted to Miss Jane T. Kolimaga for her expert assistance in the preparation of this volume. David Kritchevsky Rodolfo Paoletti William L. Holmes vii Contents LIPOPROTEINS AND DRUGS Lipoprotein Metabolism - New Insights from Cell Biology. . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 D. Steinberg Lipoprotein Metabolism in Man. . . . . . . . . . . . . . . . . . . .

Atlas of Atherosclerosis
Atlas of Atherosclerosis

Author: Peter W.F Wilson

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 273

ISBN-13: 1475793103

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This new edition is an integral source of information covering topics such as newer coronary risk factors, high-density lipoprotein metabolism, lipid-lowering drugs, endothelium and thrombosis in atherogenesis, and contributing risk factors. With over 500 exceptional photographs, diagrams, and charts, each chapter illustrates an important facet of diagnosing and treating this common and often fatal disease.

Prevent and Reverse Heart Disease
Prevent and Reverse Heart Disease

Author: Caldwell B. Esselstyn Jr. M.D.

Publisher: Penguin

Published: 2008-01-31

Total Pages: 329

ISBN-13: 1583333002

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The New York Times bestselling guide to the lifesaving diet that can both prevent and help reverse the effects of heart disease Based on the groundbreaking results of his twenty-year nutritional study, Prevent and Reverse Heart Disease by Dr. Caldwell Esselstyn illustrates that a plant-based, oil-free diet can not only prevent the progression of heart disease but can also reverse its effects. Dr. Esselstyn is an internationally known surgeon, researcher and former clinician at the Cleveland Clinic and a featured expert in the acclaimed documentary Forks Over Knives. Prevent and Reverse Heart Disease has helped thousands across the country, and is the book behind Bill Clinton’s life-changing vegan diet. The proof lies in the incredible outcomes for patients who have followed Dr. Esselstyn's program, including a number of patients in his original study who had been told by their cardiologists that they had less than a year to live. Within months of starting the program, all Dr. Esselstyn’s patients began to improve dramatically, and twenty years later, they remain free of symptoms. Complete with more than 150 delicious recipes perfect for a plant-based diet, the national bestseller Prevent and Reverse Heart Disease explains the science behind the simple plan that has drastically changed the lives of heart disease patients forever. It will empower readers and give them the tools to take control of their heart health.