Applications of Biotechnology in Neurology
Applications of Biotechnology in Neurology

Author: Kewal K. Jain

Publisher: Springer Science & Business Media

Published: 2013-01-05

Total Pages: 667

ISBN-13: 162703272X

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Culling together excerpts from a wide range of writings by Dr. Kewal K. Jain on biotechnology topics as they relate to disorders of the nervous system, Applications of Biotechnology in Neurology covers a variety of applications for those working in life sciences and the pharmaceutical sciences, particularly those developing diagnostics and therapeutics for the nervous system. This detailed volume delves into areas such as neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, various methods of improving systemic administration of drugs for targeted delivery to the nervous system, including the use of nanobiotechnology, biotechnology-based strategies and products for neuroprotection, as well as chapters on neurosurgery and personalized neurology. Thorough, cutting-edge, and thoughtfully organized, Applications of Biotechnology in Neurology serves as an ideal guide, supplemented by 75 tables and 16 figures as well as numerous references from recent literature on this topic, which are appended to each chapter.

Application of Biomedical Engineering in Neuroscience
Application of Biomedical Engineering in Neuroscience

Author: Sudip Paul

Publisher: Springer Nature

Published: 2019-11-19

Total Pages: 483

ISBN-13: 9811371423

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This book focuses on interdisciplinary research in the field of biomedical engineering and neuroscience. Biomedical engineering is a vast field, ranging from bioengineering to brain-computer interfaces. The book explores the system-level function and dysfunction of the nervous system from scientific and engineering perspectives. The initial sections introduce readers to the physiology of the brain, and to the biomedical tools needed for diagnostics and effective therapies for various neurodegenerative and regenerative disorders. In turn, the book summarizes the biomedical interventions that are used to understand the neural mechanisms underlying empathy disorders, and reviews recent advances in biomedical engineering for rehabilitation in connection with neurodevelopmental disorders and brain injuries. Lastly, the book discusses innovations in machine learning and artificial intelligence for computer-aided disease diagnosis and treatment, as well as applications of nanotechnology in therapeutic neurology.

Gene Therapy of the Central Nervous System: From Bench to Bedside
Gene Therapy of the Central Nervous System: From Bench to Bedside

Author: Michael G. Kaplitt

Publisher: Gulf Professional Publishing

Published: 2006

Total Pages: 380

ISBN-13: 9780123976321

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Few areas of biomedical research provide greater opportunities to capitalize upon the revolution in genomics and molecular biology than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy in the Brain: From Bench to Bedside represents the definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped to create the field as well as those who are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects which would be of interest to anyone who is currently using or contemplating exploring gene therapy for neurobiological applications. Basic gene transfer technologies are discussed, with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells. Numerous research applications are reviewed, particularly in complex fields such as behavioral neurobiology. Several preclinical areas are also covered which are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis. Among the most exciting advances in recent years has been the use of neurological gene therapy in human clinical trials, including Parkinson's disease, Canavan disease and Batten disease. Finally, readers will find "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use. This work provides up-to-date information and key insights into those gene therapy issues which are important to both scientists and clinicians focusing upon the brain and central nervous system.

Non-invasive Neuromodulation of the Central Nervous System : Opportunities and Challenges : Workshop Summary
Non-invasive Neuromodulation of the Central Nervous System : Opportunities and Challenges : Workshop Summary

Author: Institute of Medicine (U.S.). Forum on Neuroscience and Nervous System Disorders

Publisher:

Published: 2015

Total Pages: 0

ISBN-13: 9780309376181

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Based on advances in biotechnology and neuroscience, non-invasive neuromodulation devices are poised to gain clinical importance in the coming years and to be of increasing interest to patients, clinicians, health systems, payers, and industry. Evidence suggests that both therapeutic and non-therapeutic applications of non-invasive neuromodulation will continue to expand in coming years, particularly for indications where treatments are currently insufficient, such as drug-resistant depression. Given the growing interest in non-invasive neuromodulation technologies, the Institute of Medicine's Forum on Neuroscience and Nervous System Disorders convened a workshop, inviting a range of stakeholders - including developers of devices and new technologies, researchers, clinicians, ethicists, regulators, and payers - to explore the opportunities, challenges, and ethical questions surrounding the development, regulation, and reimbursement of these devices for the treatment of nervous system disorders as well as for non-therapeutic uses, including cognitive and functional enhancement. This report highlights the presentation and discussion of the workshop.

The Business of Healthcare Innovation
The Business of Healthcare Innovation

Author: Lawton R. Burns

Publisher: Cambridge University Press

Published: 2005-08-25

Total Pages: 400

ISBN-13: 9780521838986

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The first wide-ranging analysis of business trends in the manufacturing segment of the health care industry.

Brain and Human Body Modeling 2020
Brain and Human Body Modeling 2020

Author: Sergey N. Makarov

Publisher: Springer Nature

Published: 2021

Total Pages: 395

ISBN-13: 3030456234

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The 41st Annual International Conference of the IEEE EMBS, took place between July 23 and 27, 2019, in Berlin, Germany. The focus was on "Biomedical engineering ranging from wellness to intensive care." This conference provided an opportunity for researchers from academia and industry to discuss a variety of topics relevant to EMBS and hosted the 4th Annual Invited Session on Computational Human Models. At this session, a bevy of research related to the development of human phantoms was presented, together with a substantial variety of practical applications explored through simulation.

Neurotechnology
Neurotechnology

Author: James Giordano

Publisher: CRC Press

Published: 2012-04-26

Total Pages: 357

ISBN-13: 1439825866

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New technologies that allow us to investigate mechanisms and functions of the brain have shown considerable promise in treating brain disease and injury. These emerging technologies also provide a means to assess and manipulate human consciousness, cognitions, emotions, and behaviors, bringing with them the potential to transform society. Neurotechnology: Premises, Potential, and Problems explores the technical, moral, legal, and sociopolitical issues that arise in and from today’s applications of neuroscience and technology and discusses their implications for the future. Some of the issues raised in this thought-provoking volume include: Neurotechnology in education: an enablement, a treatment, or an enhancement? The potential and limitations of neuroimaging technology in determining patient prognoses Tissue implantation technology as a way of engendering personalized medicine Neuroprostheses: restoration of functions of the disabled vs. enhancement to transhuman capabilities Deep brain stimulation and its use in restoring, preserving, or changing patients’ personal identity The benefit and risk of cognitive performance tools Cyborg technology and its potential to change our vision of humanity Methodologies for reducing the risk of neurotechnology’s impact on ethical, legal, and social issues With contributions from an international group of experts working on the cutting edge of neurotechnology, this volume lays the groundwork to appreciate the ethical, legal, and social aspects of the science in ways that keep pace with this rapidly progressing field.

Guide to Research Techniques in Neuroscience
Guide to Research Techniques in Neuroscience

Author: Matt Carter

Publisher: Academic Press

Published: 2022-03-26

Total Pages: 416

ISBN-13: 0323915612

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Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more Clear, straightforward explanations of each technique for anyone new to the field A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture Detailed recommendations on where to find protocols and other resources for specific techniques "Walk-through" boxes that guide readers through experiments step-by-step

Optogenetics
Optogenetics

Author: Hiromu Yawo

Publisher: Springer Nature

Published: 2021-01-05

Total Pages: 648

ISBN-13: 9811587639

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This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a “must read” for all involved in research in any way related to optogenetics.

Use of Laboratory Animals in Biomedical and Behavioral Research
Use of Laboratory Animals in Biomedical and Behavioral Research

Author: National Research Council

Publisher: National Academies Press

Published: 1988-02-01

Total Pages: 113

ISBN-13: 0309038391

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Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.