Nanostructures for Antimicrobial Therapy

Nanostructures for Antimicrobial Therapy

Author: Anton Ficai

Publisher: Elsevier

Published: 2017-05-29

Total Pages: 724

ISBN-13: 0323461514

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Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. - Shows how nanoantibiotics can be used to more effectively treat disease - Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs - Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area


Photodynamic Inactivation of Microbial Pathogens

Photodynamic Inactivation of Microbial Pathogens

Author: Michael R Hamblin

Publisher: Royal Society of Chemistry

Published: 2011-06-06

Total Pages: 451

ISBN-13: 1849733082

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Photodynamic therapy (PDT) was discovered over one hundred years ago after observing the death of microorganisms upon exposure to dyes and light. It is the combination of non-toxic dyes and harmless visible light that, in the presence of oxygen, produce highly toxic reactive species. The principal medical application during the last century was in cancer therapy but, in these days of rising antibiotic resistance, PDT shows increasing promise as an alternative approach to treating infections. PDT has also been used in blood product sterilization, peridontology, acne reduction, and the treatment of viral lesions such as those caused by human papilloma virus. It may also have potential as an environmentally friendly pesticide. This is the first and only book to comprehensively cover the use of light and photosensitising agents for controlling microbial pathogens. It provides a comprehensive and up-to-date coverage of an emerging field. There are several chapters on the design of antimicrobial photosensitizers, their use to kill pathogenic organisms and their success in treating infections in animal models. It has long been known that gram-positive bacteria are highly susceptible to photoinactivation but the book also discusses means of widening the range of microorganisms that can be tackled by PDT. Edited by two pioneers in the application of PDT to medical and environmental issues, this book covers the basic science, translational research in animals, and the clinical applications in various medical specialities. It represents an indispensable resource for microbiologists and infectious disease doctors as well as dentists, dermatologists, gastroenterologists and transfusion specialists.


Photodynamic Medicine

Photodynamic Medicine

Author: Herwig Kostron

Publisher: Royal Society of Chemistry

Published: 2016

Total Pages: 680

ISBN-13: 1782624511

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Comprehensive Series in Photochemical and Photobiological Sciences. Photodynamic therapy (PDT) is increasingly being used amongst health practitioners in combating a variety of disease. This book reviews the current state of development of PDT, and also presents the foreseeable advancements of the field in the next decade. Practitioners in biological sciences, biotechnology and medicinal and pharmaceutical chemistry will find this book an invaluable source of information. Chapters are drawn from research discusses at the 10th International Symposium on Photodynamic Therapy and Photodiagnosis in Clinical Practice in Brixen and are written and edited by leaders in the field. Mirroring the philosophy of that meeting, this book contains an informative balance of the basic sciences and clinical applications of PDT. Following an introduction to PDT, its history, and how techniques have developed, chapter serve as a practical guide for practitioners, covering topics such as sensitizer dosage and light dosage, and examples of relevant studies. The text goes further tp explore areas outside the medical field, such as the impact of PDT on society and the environment, and the economics of therapies. This book is dedicated to the memory of Professor Giulio Jori, and expert in this field, who sadly passed away on the 23rd December 2014.


Oral Biofilms

Oral Biofilms

Author: S. Eick

Publisher: Karger Medical and Scientific Publishers

Published: 2020-12-21

Total Pages: 247

ISBN-13: 3318068527

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Biofilms are highly organized polymicrobial communities that are embedded in an extracellular matrix and formed on natural and artificial surfaces. In the oral cavity, biofilms are formed not only on natural teeth, but also on restorative materials, prosthetic constructions, and dental implants. Oral diseases like caries, gingivitis, periodontitis, and also pulp inflammation are associated with biofilms. This publication is an up-to-date overview on oral biofilms from different clinically relevant perspectives. Experts comprising basic researchers and clinicians report on recent research relating to biofilms - from general summaries to recommendations for daily clinical work. This book covers all aspects of oral biofilms, including models used in the laboratory, biofilms in dental water unit lines, periodontal and peri-implant biofilms, caries-related biofilms, halitosis, endodontic biofilms, and Candida infections, as well as biofilms on dental materials and on orthodontic appliances. Several chapters deal with anti-biofilm therapy, from the efficacy of mechanical methods and the use of antimicrobials, to alternative concepts. This publication is particularly recommended to dental medicine students, practitioners, other oral healthcare professionals, and scientists with an interest in translational research on biofilms.


Nanostructures for Antimicrobial and Antibiofilm Applications

Nanostructures for Antimicrobial and Antibiofilm Applications

Author: Ram Prasad

Publisher: Springer Nature

Published: 2020-05-12

Total Pages: 461

ISBN-13: 3030403378

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In the pursuit of technological advancement in the field of biotechnology and pharmaceutical industries to counteract health issues, bacterial infections remain a major cause of morbidity and mortality. The ability of bacterial pathogens to form biofilms further agglomerates the situation by showing resistance to conventional antibiotics. To overcome this serious issue, bioactive metabolites and other natural products were exploited to combat bacterial infections and biofilm-related health consequences. Natural products exhibited promising results in vitro, however; their efficacy in in vivo conditions remain obscured due to their low-solubility, bioavailability, and biocompatibility issues. In this scenario, nanotechnological interventions provide a multifaceted platform for targeted delivery of bioactive compounds by slow and sustained release of drug-like compounds. The unique physico-chemical properties, biocompatibility and eco-friendly nature of bioinspired nanostructures has revolutionized the field of biology to eradicate microbial infections and biofilm-related complications. The green-nanotechnology based metal and metal oxide nanoparticles and polymeric nanoparticles have been regularly employed for antimicrobial and antibiofilm applications without causing damage to host tissues. The implications of these nanoparticles toward achieving sustainability in agriculture by providing systemic resistance against a variety of phytopathogens therefore plays crucial role in growth and crop productivity. Also the advent of smart and hybrid nanomaterials such as metal-based polymer nanocomposites, lipid-based nanomaterials and liposomes have the inherent potential to eradicate bacterial biofilm-related infections in an efficient manner. The recent development of carbon-based nanomaterials such as carbon nanotubes (CNTs) and silica based nanomaterials such as mesoporous silica nanoparticles (MSNs) also exploit a target of dreadful healthcare conditions such as cancer, immunomodulatory diseases, and microbial infections, as well as biofilm-related issues owing to their stability profile, biocompatibility, and unique physio-chemical properties. Recently novel physical approaches such as photothermal therapy (PTT) and antimicrobial photodynamic therapy (aPDT) also revolutionized conventional strategies and are engaged in eradicating microbial biofilm-related infections and related health consequences. These promising advancements in the development of novel strategies to treat microbial infections and biofilm-related multidrug resistance (MDR) phenomenon may provide new avenues and aid to conventional antimicrobial therapeutics.


Lasers in Dentistry

Lasers in Dentistry

Author: Patricia M. Freitas

Publisher: John Wiley & Sons

Published: 2015-04-27

Total Pages: 372

ISBN-13: 1118275020

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Lasers have become an increasingly useful tool in conventional dental practice. Their precision and less invasive quality make them an attractive technology in esthetic and pediatric dentistry, oral medicine, and a range of other dental procedures. Lasers in Dentistry: Guide for Clinical Practice is a comprehensive, yet concise and easy-to-use guide to integrating lasers into conventional clinical practice. The book begins by providing the reader a thorough understanding of how lasers work and their varied effects on oral tissues. Subsequent chapters are organized by procedure type, illustrating common clinical techniques with step-by-step illustrations and case examples. In addition, each chapter provides an overview of the latest research for use in clinical practice. More comprehensive than at atlas yet practical and clinically oriented in its approach, Lasers in Dentistry is an essential tool for practitioners and students looking to broader their skill set in laser dentistry.


Ultrasound in Food Processing

Ultrasound in Food Processing

Author: Mar Villamiel

Publisher: John Wiley & Sons

Published: 2017-04-25

Total Pages: 764

ISBN-13: 1118964160

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Part I: Fundamentals of ultrasound This part will cover the main basic principles of ultrasound generation and propagation and those phenomena related to low and high intensity ultrasound applications. The mechanisms involved in food analysis and process monitoring and in food process intensification will be shown. Part II: Low intensity ultrasound applications Low intensity ultrasound applications have been used for non-destructive food analysis as well as for process monitoring. Ultrasonic techniques, based on velocity, attenuation or frequency spectrum analysis, may be considered as rapid, simple, portable and suitable for on-line measurements. Although industrial applications of low-intensity ultrasound, such as meat carcass evaluation, have been used in the food industry for decades, this section will cover the most novel applications, which could be considered as highly relevant for future application in the food industry. Chapters addressing this issue will be divided into three subsections: (1) food control, (2) process monitoring, (3) new trends. Part III: High intensity ultrasound applications High intensity ultrasound application constitutes a way to intensify many food processes. However, the efficient generation and application of ultrasound is essential to achieving a successful effect. This part of the book will begin with a chapter dealing with the importance of the design of efficient ultrasonic application systems. The medium is essential to achieve efficient transmission, and for that reason the particular challenges of applying ultrasound in different media will be addressed. The next part of this section constitutes an up-to-date vision of the use of high intensity ultrasound in food processes. The chapters will be divided into four sections, according to the medium in which the ultrasound vibration is transmitted from the transducers to the product being treated. Thus, solid, liquid, supercritical and gas media have been used for ultrasound propagation. Previous books addressing ultrasonic applications in food processing have been based on the process itself, so chapters have been divided in mass and heat transport, microbial inactivation, etc. This new book will propose a revolutionary overview of ultrasonic applications based on (in the authors’ opinion) the most relevant factor affecting the efficiency of ultrasound applications: the medium in which ultrasound is propagated. Depending on the medium, ultrasonic phenomena can be completely different, but it also affects the complexity of the ultrasonic generation, propagation and application. In addition, the effect of high intensity ultrasound on major components of food, such as proteins, carbohydrates and lipids will be also covered, since this type of information has not been deeply studied in previous books. Other aspects related to the challenges of food industry to incorporate ultrasound devices will be also considered. This point is also very important since, in the last few years, researchers have made huge efforts to integrate fully automated and efficient ultrasound systems to the food production lines but, in some cases, it was not satisfactory. In this sense, it is necessary to identify and review the main related problems to efficiently produce and transmit ultrasound, scale-up, reduce cost, save energy and guarantee the production of safe, healthy and high added value foods.


Infection Prevention

Infection Prevention

Author: Gonzalo Bearman

Publisher: Springer

Published: 2017-09-07

Total Pages: 311

ISBN-13: 3319609807

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This book reviews evolving areas in infection prevention on topics including contact precautions, technology implementation, specific infections, and care in various settings. The book summarizes the current data oninfection prevention, presents controversies on the various topics, and includes recommendations for patient safety. Addressing hot topics such as MRSA, C. difficile vaccination, mandatory flu vaccines, and CLABSI, this is the only text to include prevention and control overviews across a range of infection issues. Written by experts in thefield, this book contains 32 chapters that educates and presents the most cutting-edge models of care on emerging and evolving topics in infectious diseases. Infection Prevention: New Perspectives and Controversies is a valuable resource for infection prevention professionals, healthcare quality and safety professionals, caring for patients in in- and outpatient settings.


Pathogenesis and Treatment of Acne and Rosacea

Pathogenesis and Treatment of Acne and Rosacea

Author: Christos C. Zouboulis

Publisher: Springer

Published: 2014-07-28

Total Pages: 729

ISBN-13: 3540693750

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This book, written by experts from across the world, provides comprehensive coverage of acne and rosacea, focusing in particular on pathogenesis and treatment but also considering clinical aspects, prognostic factors, and impacts on quality of life. Both standard knowledge and important, clinically relevant insights that have emerged over the past decade are presented with the goal of assisting the reader in understanding these diseases and improving treatment outcome. It is explained how high-level research has recently given rise to a variety of new concepts in etiology and treatment, and emerging trends are also discussed. The book is in a reader-friendly format that highlights core messages with a very practical and clinical focus. Pathogenesis and Treatment of Acne and Rosacea will be an indispensable reference for all physicians who care for patients with acne or rosacea and for scientists working in the field.