Animal genetics refers to the study of genes, variation and heredity in animals. An animal's behavior, development and genetic processes are influenced by their environment and experiences. Genetic changes occur due to mutations, natural selection and evolution. The study of the heritable changes in gene function that do not arise due to a change in the DNA sequence is under the domain of epigenetics. Histone modification and DNA methylation are few mechanisms that can produce such changes. Macromolecules found in the cells, which consist of protein, RNA and DNA form a complex, which is called the chromatin. Its fundamental function is to prevent DNA damage, allow mitosis by reinforcing the DNA macromolecule, pack DNA more densely and compactly, and control the DNA replication and gene expression. The topics covered in this extensive book deal with the core aspects of animal genetics, epigenetics and chromatin. Scientists and students actively engaged in this field will find this book full of crucial and unexplored concepts. It traces the progress of this discipline and highlights some of its key concepts and applications.
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Livestock Epigenetics reviews advances in the understanding of the molecular basis of epigenetic mechanisms in gene expression in livestock species. Epigenetics impact many economically important traits from growth and development to more efficient reproduction and breeding strategies. The book opens with a broad introductory chapter that discusses the importance of an understanding of epigenetics to efficient and sustainable livestock production. In subsequent chapters the role of epigenetics in specific aspects of animal production are reviewed. The final chapter provides researchers with a valuable basis for the use of comparative epigenetics research to allow research to apply advances across organisms. Livestock Epigenetics provides detailed information on this rapidly expanding field of research with contributions from a global team of experts.
Animal genetics is a foundational discipline in the fields of animal science, animal breeding, and veterinary sciences. While genetics underpins the healthy development and breeding of all living organisms, this is especially true in domestic animals, specifically with respect to breeding for key traits. Molecular and Quantitative Animal Genetics is a new textbook that takes an innovative approach, looking at both quantitative and molecular breeding approaches. The bookprovides a comprehensive introduction to genetic principles and their applications in animal breeding. This text provides a useful overview for those new to the field of animal genetics and breeding, covering a diverse array of topics ranging from population and quantitative genetics to epigenetics and biotechnology. Molecular and Quantitative Animal Genetics will be an important and invaluable educational resource for undergraduate and graduate students and animal agriculture professionals. Divided into six sections pairing fundamental principles with useful applications, the book's comprehensive coverage will make it an ideal fit for students studying animal breeding and genetics at any level.
You Are About To Develop A Comprehensive Understanding Of The Concept Of Epigenetics, Its Place In Modern Day Medicine, And Health Optimization And Why It Is Literally Changing How We Approach The Treatment Of Various Health Problems! Modern research has now confirmed that the behavior of your genes doesn't always depend on their DNA sequence, but also on factors referred to epigenetics, and that changes in these factors can play a critical role in disease, life structures, behavior and all aspects of life. And that's not all; research also shows that therapies based on these factors have proven effective in reversing some conditions, boosting the immune system, optimizing psychology and human adaptation. Epigenetics have thus taken the center stage in understanding human biology at a deeper level, life, and evolution. But what are epigenetics, and how to they work? How does the environment affect them, and how is this "remembered" in the body? How does epigenetic therapy work? What does it treat? Isn't it risky? What is the relationship between epigenetics and the human psychology? How can we benefit from the discovery and understanding of epigenetics? If you have these and other related questions, this 2 in 1 book is for you so keep reading. Here is a bit of what you'll learn from this 2 in 1 book: • What epigenetics are, why they're important and how they work • How epigenetics relate with our experiences • How cells divide, and how genes control the growth and division of cells • The difference between the DNA, gene and chromosomes •The existing evidence of epigenetic changes, including in transgenerational epigenetic inheritance • The ins and outs of epigenetics mechanisms • The types of epigenetic therapies available today, including their risks, benefits and research on them • The effect of epigenetic control in transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping • How epigenetics work at the molecular level and the effect of DNA damage in epigenetic change • The functions of epigenetics, and how they boost mindfulness training, healthy eating and exercise • How epigenetic therapy and modifications affects diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia, mesothelioma and many more • How epigenetic modifications are used in understanding plant and animal evolution • How epigenetic mechanisms are used in understanding human adaptation, boosting memory formation, growth and reinforcing infant neurobehavior. • The role of epigenetic mechanisms in maternal care • The role of environmental chemicals in epigenetics • How epigenetics are involved in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more. • The role of environmental exposures in pathophysiology of IPF • Modulation of epigenetic marks by environmental exposures • How epigenetic regulation affects the immune system …And so much more! Whether you are a beginner or an intermediate in epigenetics, you will find this book educative, as you learn the A-Z of factors that are quickly changing our understanding of the structure of life. Don't wait…. Scroll up and click Buy Now with 1-Click or Buy Now to get started!
Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science
Epigenetics is defined as heritable changes that do not affect the DNA sequence but influence gene expression. Epigenetic changes occur at the levels of DNA, histone, protein, and chromatin structures. Proper epigenetic modifications are essential for cell differentiation and function during development, while some epigenetic modifications are passed on from parents to offspring through gametes. Therefore, alterations of epigenetic states would have serious consequences for human development and health. This realization and the advent of new technologies have encouraged the advance of epigenetic studies in recent years. Nonetheless, many aspects of epigenetics, such as regulatory mechanisms and evolutional advantages, remain to be better understood.Written by 26 scientists at the forefront of epigenetics research, this book discusses the different facets of epigenetics: from gametogenesis to child development, as well as from mechanistic studies in animal models to reviews of human clinical data.
Chance, Calculation and Life brings together 16 original papers from the colloquium of the same name, organized by the International Cultural Center of Cerisy in 2019. From mathematics to the humanities and biology, there are many concepts and questions related to chance. What are the different types of chance? Does chance correspond to a lack of knowledge about the causes of events, or is there a truly intrinsic and irreducible chance? Does chance preside over our decisions? Does it govern evolution? Is it at the origin of life? What part do chance and necessity play in biology? This book answers these fundamental questions by bringing together the clear and richly documented contributions of mathematicians, physicists, biologists and philosophers who make this book an incomparable tool for work and reflection.
Recent years have seen spectacular advances in the filed of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigentic regulation to brain functions has been accumulationg. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molcular mechanisms implicated in epigentic control and how these may operte in concert. It will be critical to unravel how specifity is achieved. The focus of this volume is on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system and on the presumed mechanisms that operate within neurons to translate them into long-lasting neuronal responses.
