Androgens II and Antiandrogens
Author:
Publisher:
Published: 1974
Total Pages: 625
ISBN-13: 9780387068831
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Medicinal Chemistry of Anticancer Drugs
Author: Carmen Avendaño
Publisher: Elsevier
Published: 2015-06-11
Total Pages: 767
ISBN-13: 0444626670
DOWNLOAD EBOOKMedicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. - Presents information in a clear and concise way using a large number of figures - Historical background provides insights on how the process of drug discovery in the anticancer field has evolved - Extensive references to primary literature
Androgens and Antiandrogens
Author: Luciano Martini
Publisher: Raven Press (ID)
Published: 1977
Total Pages: 406
ISBN-13:
DOWNLOAD EBOOKAndrogens in Gynecological Practice
Author: Leo Plouffe, Jr
Publisher: Cambridge University Press
Published: 2015-06-25
Total Pages: 261
ISBN-13: 1316298876
DOWNLOAD EBOOKA practical approach to the field of androgen excess or deprivation in women's health. The content includes multiple viewpoints on the most common disorders in this class, such as polycystic ovary disease, hirsutism and menopausal issues. Each chapter provides a combination of long-lasting clinical principles in the diagnosis and management of these patients along with a state-of-the-art review. This text takes an innovative approach to uncommon conditions (such as congenital adrenal hyperplasia, transgender conditions). In addition to presenting clinical insights, and a review of the basic science underpinning these conditions, it focuses on key concepts that can be derived from these rare conditions to the entire field. This book is an essential addition to the library for any busy clinician who is looking for a practical reference guide but also for the sub-specialist who is looking for new and thought-provoking insights in this complex scientific area.
Synthesis of Best-Seller Drugs
Author: Ruben Vardanyan
Publisher: Academic Press
Published: 2016-01-07
Total Pages: 870
ISBN-13: 0124115241
DOWNLOAD EBOOKSynthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. - Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas - Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more - Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation
Endocrine Disruption and Human Health
Author: Philippa D. Darbre
Publisher: Academic Press
Published: 2015-03-21
Total Pages: 390
ISBN-13: 0128011203
DOWNLOAD EBOOKEndocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations
Hormones and Social Behavior
Author: Donald W. Pfaff
Publisher: Springer Science & Business Media
Published: 2008-05-31
Total Pages: 204
ISBN-13: 3540792880
DOWNLOAD EBOOKThis book concentrates on two major topics: firstly, the molecular and neural biology of hormone actions relevant to normal social behaviors; and secondly, the clinical treatment of human patients in whom these behaviors have gone wrong.
Androgen Action
Author: Fahri Saatcioglu
Publisher: Humana Press
Published: 2011-08-09
Total Pages: 0
ISBN-13: 9781617792427
DOWNLOAD EBOOKAndrogens play a critical role in the development and maintenance of the male reproductive system and affect important physiological processes and pathological conditions, including the homeostasis of the normal prostate and prostate cancer. Androgen Action: Methods and Protocols is designed to provide a tool box to study various phases of androgen action, from its entry to the cell to the phenotypic response that the cell mounts, with up-to-date techniques for biochemists, molecular biologists, cell biologists, geneticists, and pathologists. The volume opens with a brief review of the research history on androgen action and prostate carcinogenesis, followed by chapters that cover state-of-the-art methods to determine androgen levels in biological tissues and fluids, experimental procedures to study the various aspects of androgen receptor activity, and methodology to study salient examples of interactions between androgen signalling and other major signalling pathways in cells. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Androgen Action: Methods and Protocols provides a comprehensive overview of, and practical guidance on, the diverse methodologies that are propelling androgen action research forward, both for normal physiology as well as in disease states.
Hyperandrogenism in Women
Author: R. Pasquali
Publisher: Karger Medical and Scientific Publishers
Published: 2019-09-09
Total Pages: 201
ISBN-13: 3318064718
DOWNLOAD EBOOKHyperandrogenism profoundly affects women’s lives from lowering self-esteem to changing cognition and affective motivation. The polycystic ovary syndrome (PCOS) is the most common androgen excess disorder worldwide. While it is not the focus of this book, some aspects are discussed. The aim of this book is to improve understanding of androgen excess and its impact on several conditions. Topics include development of adipose tissue in females, insulin sensitivity, congenital adrenal hyperplasia, and Cushing’s disease/syndrome. There is also a discussion of PCOS with emphasis on in utero origins and specific genetic and epigenetic factors. This book provides a wealth of relevant information for every endocrinologist and gynecologist who wants to broaden their knowledge of androgens in various conditions.
Human Sexuality and Its Problems
Author: John Bancroft
Publisher:
Published: 1989
Total Pages: 745
ISBN-13: 9780443034558
DOWNLOAD EBOOKThis is an updated multidisciplinary and scholarly account of the determinants of human sexuality including sexual development, anatomy and physiology, biochemistry and endocrinology of sexual behaviour in addition to sociological and psychological aspects.
