Analysis of Cardiac Development
Analysis of Cardiac Development

Author: Rafael Beyar

Publisher: John Wiley & Sons

Published: 2010-03-22

Total Pages: 241

ISBN-13: 1573317470

DOWNLOAD EBOOK

This volume, the result of three days of interactive sessions among world leaders in the cardiac sciences, summarizes the most up-to-date information about development and cardiogenesis signaling in cell-based therapy, as well as developmental aspects of the formation of the embryonic heart, including the effect of mechanical load on differentiation. Other topics covered include: signaling and repair strategies, cell and gene therapy for the treatment of postmyocardial infarction, signaling, vascularization methods in engineering embryonic cardiac tissue, and molecular methods to improve survival of human embryonic stem cell–derived cardiomyocytes; developmental and evolutional cardiology; novel strategies for treatment of atrial fibrillation and channel molecular physiology in remodeling and hypertrophy; multiscale modeling for metabolism and flows, including force development, mechanics of cardiac contraction, and ATP supply and demand aspects; aging, interactions, and interference aspects include fibroblast-myocyte-capillary communications, nonuniformities in contraction, calcium channels as oxygen sensors, and epigenetics of heart failure; and macroscale phenomena and clinical aspects, including various clinical aspects of modern cardiology such as navigation methods for cardiac interventions and control of cardiac function by changes in energetic demand. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Heart Development and Disease
Heart Development and Disease

Author: Benoit G. Bruneau

Publisher:

Published: 2020

Total Pages: 0

ISBN-13: 9781621823582

DOWNLOAD EBOOK

Development of the heart is a complex process and can lead to serious congenital disease if the process goes awry. This book provides a detailed description of the cell lineages involved in heart development and how their migration and morphogenesis are controlled. It also examines the genetic and environmental bases for congenital heart disease and how model systems are revealing more about the processes involved. Topics covered in this essential volume include: - Anatomy of a Developing Heart - Genetic and Epigenetic Control of Heart Development - Development of the Cardiac Conduction System - Genetic Basis of Human Congenital Heart Disease - In Vivo and In Vitro Genetic Models of Congenital Heart Disease

Vector Generalized Linear and Additive Models
Vector Generalized Linear and Additive Models

Author: Thomas W. Yee

Publisher: Springer

Published: 2015-09-11

Total Pages: 606

ISBN-13: 149392818X

DOWNLOAD EBOOK

This book presents a greatly enlarged statistical framework compared to generalized linear models (GLMs) with which to approach regression modelling. Comprising of about half-a-dozen major classes of statistical models, and fortified with necessary infrastructure to make the models more fully operable, the framework allows analyses based on many semi-traditional applied statistics models to be performed as a coherent whole. Since their advent in 1972, GLMs have unified important distributions under a single umbrella with enormous implications. However, GLMs are not flexible enough to cope with the demands of practical data analysis. And data-driven GLMs, in the form of generalized additive models (GAMs), are also largely confined to the exponential family. The methodology here and accompanying software (the extensive VGAM R package) are directed at these limitations and are described comprehensively for the first time in one volume. This book treats distributions and classical models as generalized regression models, and the result is a much broader application base for GLMs and GAMs. The book can be used in senior undergraduate or first-year postgraduate courses on GLMs or categorical data analysis and as a methodology resource for VGAM users. In the second part of the book, the R package VGAM allows readers to grasp immediately applications of the methodology. R code is integrated in the text, and datasets are used throughout. Potential applications include ecology, finance, biostatistics, and social sciences. The methodological contribution of this book stands alone and does not require use of the VGAM package.

Cardiovascular Disability
Cardiovascular Disability

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2010-12-04

Total Pages: 304

ISBN-13: 030915698X

DOWNLOAD EBOOK

The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.

Development of the Cardiac Conduction System
Development of the Cardiac Conduction System

Author: Derek J. Chadwick

Publisher: John Wiley & Sons

Published: 2005-01-21

Total Pages: 300

ISBN-13: 0470868031

DOWNLOAD EBOOK

The pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat. Dysfunction of this system can be a direct cause of cardiac conduction disturbance, arrhythmias and sudden cardiac death. A wealth of information has been collected over many years on the unique histological, morphological and phenotypic characteristics of specialized cardiac tissues. The cellular and molecular mechanisms that govern development of the PCS are now starting to be understood. This book draws together contributions from an international and interdisciplinary group of experts working on both basic and clinical aspects of cardiac development. It features reviews of the structure and function of the developing PCS, discussion of the molecular and cellular mechanisms regulating embryological development of this system and studies on the fundamental basis of PCS pathology. The book also considers how novel therapeutic interventions based on understanding of the developmental biology of cardiac pacemaking and conduction tissues might ultimately impact on clinical medicine.

Atlas of Heart Anatomy and Development
Atlas of Heart Anatomy and Development

Author: Florin Mihail Filipoiu

Publisher: Springer Science & Business Media

Published: 2013-11-29

Total Pages: 254

ISBN-13: 1447153820

DOWNLOAD EBOOK

​This heart anatomy book describes the cardiac development and cardiac anatomy in the development of the adult heart, and is illustrated by numerous images and examples. It contains 550 images of dissected embryo and adult hearts, obtained through the dissection and photography of 235 hearts. It has been designed to allow the rapid understanding of the key concepts and that everything should be clearly and graphically explained in one book. This is an atlas of cardiac development and anatomy of the human heart which distinguishes itself with the use of 550 images of embryonic, fetal and adult hearts and using text that is logical and concise. All the mentioned anatomical structures are shown with the use of suggestive dissection images to emphasize the details and the overall location. All the images have detailed comments, while clinical implications are suggested. The dissections of different hearts exemplify the variability of the cardiac structures. The electron and optical microscopy images are sharp and provide great fidelity. The arterial molds obtained using methyl methacrylate are illustrative and the pictures use suggestive angles. The dissections were made on human normal and pathological hearts of different ages, increasing the clinical utility of the material contained within.​

Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

Author: Toshio Nakanishi

Publisher: Springer Nature

Published: 2020-02-28

Total Pages: 374

ISBN-13: 9811511853

DOWNLOAD EBOOK

This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.

Cardiac Development
Cardiac Development

Author: Makoto Nagano

Publisher: Springer Science & Business Media

Published: 2002-08-31

Total Pages: 296

ISBN-13: 9781402070525

DOWNLOAD EBOOK

The importance of the developmental approach for experimental and clinical cardiology is indisputable. Clinical-epidemiological studies have clearly shown that the risk factors of serious cardiovascular diseases, such as atherosclerosis and ischemic heart disease, are already present during the early phases of ontogenetic development. Furthermore, congenital cardiovascular malformations remain the single largest cause of infant mortality from congenital defects in industrial countries. It is therefore not surprising that the interest of theoretical and clinical cardiologists in the developmental approach keeps increasing. Advances in molecular biology accelerated this trend substantially. This book is based on contributions presented at the international symposium The Developing Heart in Prague in May 2000. It is our contention that the biological, electrophysiological, morphological, functional, biochemical and functional approaches employed by distinguished scientists worldwide will provide the reader with a global picture for changes characterizing the developing heart. It should stimulate the curiosity of cardiovascular scientists in gaining insight into the mechanisms of normal and pathological development.

Congenital Heart Diseases: The Broken Heart
Congenital Heart Diseases: The Broken Heart

Author: Silke Rickert-Sperling

Publisher: Springer

Published: 2015-12-18

Total Pages: 745

ISBN-13: 3709118832

DOWNLOAD EBOOK

This book provides comprehensive insights into congenital heart disease from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways. It is divided into three parts: an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and related animal models and pathways. Taken together these chapters, which were written by and for clinicians and researchers, provide an integrated and cutting-edge resource for all those who want to learn more about both the clinical aspects and the genetic and molecular basis of congenital heart disease.