Allergic Asthma Immunopathogenesis
Allergic Asthma Immunopathogenesis

Author: Seyyed Shamsadin Athari

Publisher: Elsevier

Published: 2024-05-29

Total Pages: 210

ISBN-13: 0443155038

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Asthma is a chronic complicated airway disease whose mortality and morbidity rates have increased worldwide. Some common treatments for asthma cannot control it nor even prevent simple inflammation and relieve shortness of breath, so understanding its molecular pathways and pathophysiology is required in order to better understand the disease and to diagnose, control and treat it. Allergic Asthma Immunopathogenesis: Immunopathology of the Allergic Asthma presents a new glance to the allergic asthma pathophysiology by focusing on the immunopathogenesis and allergo-inflammation mechanisms of asthma and cell signaling pathways that can be used for various research purposes, including the design of anti-asthma treatment and target therapy for scientists and researchers. Covers new molecular pathophysiology mechanisms and cell signaling pathways in pathogenesis of allergic asthma that have been introduced in recent research Discusses immunologic basis of the allergy and hyperresponsiveness Includes results of recent research focusing on the diagnosis and treatment of allergic asthma

The Immunological Basis of Asthma
The Immunological Basis of Asthma

Author: Bart Lambrecht

Publisher: CRC Press

Published: 2003-02-26

Total Pages: 711

ISBN-13: 082474764X

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This text assesses the role of dendritic cells, T and B lymphocytes, epithelial and mast cells, eosinophils, neutrophils, macrophages, and their products in the initiation and progression of airway inflammation, regulation, and repair. It unveils advances in immunology and cell biology to generate new therapeutic regimens for inflammatory and aller

Role of CD4+T cell sub-populations in allergic asthma
Role of CD4+T cell sub-populations in allergic asthma

Author: Shakti P. Pattanayak

Publisher: GRIN Verlag

Published: 2016-07-27

Total Pages: 47

ISBN-13: 3656985499

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Scientific Essay from the year 2016 in the subject Medicine - Pharmacology, Pharmacy, , language: English, abstract: Asthma is a chronic disorder specifically characterized by severe inflammation and constriction, mucus hyper-secretion and hyper-responsiveness in the airway. Allergic Asthma (AA) is characterized by discontinuous airway obstruction that may cause temporary to severe asphyxiation and can consequence into death. Airway obstruction in asthma is because of rigorous inflammation concerning multi-cellular components together with eosinophils, neutrophils, CD4+T lymphocytes & mast cells, with eosinophilic infiltration being the most conspicuous feature. The multifaceted phenotype of AA suggested being elevated from multiple interactions of infiltrating and structural cells that is coordinated by T helper 2 (TH2) cells consequential in chronic airway inflammation. By extremely secreting convinced mediators like interleukin (IL)-4, IL-5, and IL-13, which grasps a key point in asthma pathogenesis cause erratic degree of broncho-obstruction, increased mucus production, and airway remodeling. There are a variety of T cell which plays a significant role in AA that is TH1, TH2, TH17, regulatory T cell, TH3 TH22, TH25, TH9 and others. There are various molecular signaling molecules such as STAT4, FOXp3, GATA-3 and T-bet which regulates CD4+T cells in AA. Nowadays the approach to manage asthma is based on inhaled bronchodilator and corticosteroids. But the research is on the mechanism of some promising phytomedicines. we summarized here with some mechanisms of some flavonoids to alleviate AA through CD4+T cells. In conclusion, we found that the CD4+T-cell subpopulations played some major contribution in regulating/modulating the AA and interestingly, the natural potent anti-oxidant & anti- inflammatory compounds such as flavonoids could able to attenuate the AA by regulating these subpopulations of CD4+T-cells or the signaling molecules involved in the pathogenesis.

Immunological Mechanisms in Asthma and Allergic Diseases
Immunological Mechanisms in Asthma and Allergic Diseases

Author: Douglas S. Robinson

Publisher: Karger Medical and Scientific Publishers

Published: 2000-01-01

Total Pages: 227

ISBN-13: 3805571127

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This book explores the cellular and molecular mechanisms involved in asthma and allergic diseases, from basic immunology to the treatment of patients. Arising from a special symposium held to celebrate Professor A. Barry Kay's 20th anniversary as Head of the Department of Allergy and Clinical Immunology at the National Heart and Lung Institute, London, the publication presents 18 review articles by an impressive cross section of experts in the field. Topics considered include Th1 and Th2 cells, the regultion of Th2 cytokine transcription, the role of T cells in the immunopathogenesis of asthma, and MHC-restricted IgE-independent T-cell-induced late-phase responses in human subjects. Further chapters focus on eosinophil adhesion and activation, the role of C-C chemokines in the recruitment of eosinophils, and the interactions between eosinophils and fibroblasts. T-cell recruitment and T-cell interactions in cutaneous basophil hypersensitivity and fibrotic lung disease are discussed, as is the molecular pathology of allergic disease. Finally, treatment approaches are considered in chapters on the molecular basis of corticosteroid actions in asthma, immunosuppression in asthma, and immunotherapy of allergic diseases.

Essential Pediatric Allergy, Asthma and Immunology
Essential Pediatric Allergy, Asthma and Immunology

Author: Raoul L. Wolf

Publisher: McGraw-Hill Medical Publishing

Published: 2004

Total Pages: 244

ISBN-13:

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A practical and concise guide to the assessment of allergic disorders, congenital immunodeficiency, and asthma in the child and adolescent. Focuses on the approach to diagnosis and treatment of childhood asthma, which is an increasing problem in general pediatrics. Featuring tables, bulleted lists, and a drug formulary, this book provides a quick but substantial reference to practitioners and residents.

Allergy and Clinical Immunology
Allergy and Clinical Immunology

Author: Hugh A. Sampson

Publisher: John Wiley & Sons

Published: 2015-02-26

Total Pages: 480

ISBN-13: 111860914X

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Mount Sinai Expert Guides: Allergy and Clinical Immunology will provide trainees in allergy and immunology with an extremely clinical and accessible handbook covering the major disorders and symptoms, their diagnosis and clinical management. Perfect as a point-of-care resource on the hospital wards and also as a refresher for board exam preparation, the focus throughout is on providing rapid reference, essential information on each disorder to allow for quick, easy browsing and assimilation of the must-know information. All chapters follow a consistent template including the following features: An opening bottom-line/key points section Classification, pathogenesis and prevention of disorder Evidence-based diagnosis, including relevant algorithms, laboratory and imaging tests, and potential pitfalls when diagnosing a patient Disease management including commonly used medications with dosages, management algorithms and how to prevent complications How to manage special populations, ie, in pregnancy, children and the elderly The very latest evidence-based results, major society guidelines and key external sources to consult In addition, the book comes with a companion website housing extra features such as case studies with related questions for self-assessment, key patient advice and ICD codes. Each guide also has its own mobile app available for purchase, allowing you rapid access to the key features wherever you may be. If you're specialising in allergy and immunology and require concise, practical and clinical guidance from one of the world's leading institutions in this field, then this is the perfect book for you. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.

Severe Asthma
Severe Asthma

Author: Kian Fan Chung

Publisher: European Respiratory Society

Published: 2019-06-01

Total Pages: 360

ISBN-13: 1849841047

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Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.

Allergens and Respiratory Pollutants
Allergens and Respiratory Pollutants

Author: Marc A. Williams

Publisher: Elsevier

Published: 2011-07-18

Total Pages: 315

ISBN-13: 1908818069

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Allergens and respiratory pollutants is a collection of 12 authoritative papers that draws upon the collective expertise of world leaders in the fields of innate immunity, immunotoxicology and pulmonary biology. The book critically explores the biological and immunological mechanisms that contribute to immune dysfunction on exposure to allergens and the susceptibility to infectious disease on exposure to ambient pollutants. The clinical relevance of exposure to ambient airborne xenobiotics is critically discussed and collectively, this book provides an educational forum that links the health effects of environmental exposures, immune dysfunction and inflammatory airways disease. Discusses recent advances in our understanding of cell-mediated innate immune mechanisms that occur during allergic inflammation and provides important timely coverage of diseases of concern and how such diseases are influenced by a dysfunctional immune system Provides useful information on linking environmental 'danger signals' that provoke immune dysfunction and exacerbation of existing disease Draws upon the collective expertise of an international college of leaders in the field, but also provides chapters that provide essential reference material

The Parallel March of Asthma and Allergy in Childhood: A Multi-Perspective Approach
The Parallel March of Asthma and Allergy in Childhood: A Multi-Perspective Approach

Author: Luis Garcia-Marcos

Publisher: Frontiers Media SA

Published: 2018-07-24

Total Pages: 152

ISBN-13: 2889455297

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It has not been yet clarified whether allergy and asthma are part of the same condition or they follow a parallel path. This Research Topic aims to try and put some light in this parallel march going through crucial topics: from prenatal events to later risk factors such as obesity; and from basic immunology to immunotherapy, both subcutaneous and sublingual. We hope the readers can infer their own conclusions as what is first: egg or chicken.