Biomaterials science has advanced dramatically in the past 50 years with the increased cooperation between engineers chemists and biologists. Whilst previously biomaterials may have been erroneously thought to encompass dressing materials or implant structures designed to replace damaged or diseased tissue, the range of clinical applications of these materials is immense. Truly "Smart" biomaterials, which have the ability to recognise, respond to and even record their environment, now exist. The presentations in this volume reflect the true inter-disciplinary nature of biomaterials science; with contributions from polymer chemists, engineers, biologists and clinicians. The presentations show the potential of these collaborations and describe how advanced biomaterials have and are being employed not only in theraputic applications, but also increasingly in diagnosis and treatment in medical science.
First of all, I would like to share the great pleasure of the successful five-day symposium with every participant in the 5th Iketani Conference which was held in Kagoshima from April1S (Tuesday) to 22 (Saturday), 1995. Outstanding speakers enthusiastically presented their up-to-the-minute results. Relatively little time was allotted for each presentation to ensure asdnuch time· as possible for intensive discussions on the particular topics that had just been p~esented: I was delighted to see that the lectures were of high quality, and the discu,ssionswere lively, exciting, and productive in a congenial atmosphere. We also had 92 papers in the poster ·session, in which young (and relatively young) scientists made every effort to present the novel results of their research in advanced biomaterials and drug delivery systems (DDS). I believe some of the research is most promising and will become noteworthy in the twenty-first century. It was a privilege for me to deliver a lecture at the special session of the symposium. In my introductory remarks, I pointed out five key terms in multifaceted biomaterials research: materials design, concept or methodology, devices, properties demanded, and fundamentals. I am confident that innovative progress in device manufacturing for end-use, e.g., artificial organs, vascular grafts, and DDS, can be brought about only through properly designed advanced materials that exhibit the desired functionality at the interface with any living body.
Advances in Polyurethane Biomaterials brings together a thorough review of advances in the properties and applications of polyurethanes for biomedical applications. The first set of chapters in the book provides an important overview of the fundamentals of this material with chapters on properties and processing methods for polyurethane. Further sections cover significant uses such as their tissue engineering and vascular and drug delivery applications Written by an international team of leading authors, the book is a comprehensive and essential reference on this important biomaterial. - Brings together in-depth coverage of an important material, essential for many advanced biomedical applications - Connects the fundamentals of polyurethanes with state-of-the-art analysis of significant new applications, including tissue engineering and drug delivery - Written by a team of highly knowledgeable authors with a range of professional and academic experience, overseen by an editor who is a leading expert in the field
This cutting-edge book focuses on the emerging area of biomaterials and biodevices that incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities The design and development of biomaterials play a significant role in the diagnosis, treatment, and prevention of diseases. When used with highly selective and sensitive biomaterials, cutting-edge biodevices can allow the rapid and accurate diagnosis of disease, creating a platform for research and development, especially in the field of treatment for prognosis and detection of diseases in the early stage. This book emphasizes the emerging area of biomaterials and biodevices that incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities. The 15 comprehensive chapters written by leading experts cover such topics as: The use of severe plastic deformation technique to enhance the properties of nanostructured metals Descriptions of the different polymers for use in controlled drug release Chitin and chitosan as renewable healthcare biopolymers for biomedical applications Innovated devices such as “label-free biochips” and polymer MEMS Molecular imprinting and nanotechnology Prussian Blue biosensing applications The evaluation of different types of biosensors in terms of their cost effectiveness, selectivity, and sensitivity Stimuli-responsive polypeptide nanocarriers for malignancy therapeutics
With its content taken from only the very latest results, this is an extensive summary of the various polymeric materials used for biomedical applications. Following an introduction listing various functional polymers, including conductive, biocompatible and conjugated polymers, the book goes on to discuss different synthetic polymers that can be used, for example, as hydrogels, biochemical sensors, functional surfaces, and natural degradable materials. Throughout, the focus is on applications, with worked examples for training purposes as well as case studies included. The whole is rounded off with a look at future trends.
In-depth information on natural biomaterials and their applications for translational medicine! Undiluted expertise: edited by world-leading experts with contributions from top-notch international scientists, collating experience and cutting-edge knowledge on natural biomaterials from all over the world A must-have on the shelf in every biomaterials lab: graduate and PhD students beginning their career in biomaterials science and experienced researchers and practitioners alike will turn to this comprehensive reference in their daily work Link to clinical practice: chapters on translational research make readers aware of what needs to be considered when a biomaterial leaves the lab to be routinely used
Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. - Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine - Includes the translational or commercialization status of these new biomaterials - Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine - Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials
This book covers the properties of biomaterials that have found wide clinical applications, while also reviewing the state-of-the-art in the development towards future medical applications, starting with a brief introduction to the history of biomaterials used in hip arthroplasty. The book then reviews general types of biomaterials – polymers, ceramics, and metals, as well as different material structures such as porous materials and coatings and their applications – before exploring various current research trends, such as biodegradable and porous metals, shape memory alloys, bioactive biomaterials and coatings, and nanometals used in the diagnosis and therapy of cancer. In turn, the book discusses a range of methods and approaches used in connection with biomaterial properties and characterization – chemical properties, biocompatibility, in vivo behaviour characterisation, as well as genotoxicity and mutagenicity – and reviews various diagnostic techniques: histopathological analysis, imagining techniques, and methods for physicochemical and spectroscopic characterization. Properties of stent deployment procedures in cardiovascular surgeries, from aspects of prediction, development and deployment of stent geometries are presented on the basis of novel modelling approaches. The last part of the book presents the clinical applications of biomaterials, together with case studies in dentistry, knee and hip prosthesis. Reflecting the efforts of a multidisciplinary team of authors, gathering chemical engineers, medical doctors, physicists and engineers, it presents a rich blend of perspectives on the application of biomaterials in clinical practice. The book will provide clinicians with an essential review of currently available solutions in specific medical areas, also incorporating non-medical solutions and standpoints, thus offering them a broader selection of materials and implantable solutions. This work is the result of joint efforts of various academic and research institutions participating in WIMB Tempus project, 543898-TEMPUS-1-2013-1-ES-TEMPUS-JPHES, "Development of Sustainable Interrelations between Education, Research and Innovation at WBC Universities in Nanotechnologies and Advanced Materials where Innovation Means Business", co-funded by the Tempus Programme of the European Union.
Advances in Calcium Phosphate Biomaterials presents a comprehensive, state-of-the-art review of the latest advances in developing calcium phosphate biomaterials and their applications in medicine. It covers the fundamental structures, synthesis methods, characterization methods, and the physical and chemical properties of calcium phosphate biomaterials, as well as the synthesis and properties of calcium phosphate-based biomaterials in regenerative medicine and their clinical applications. The book brings together these new concepts, mechanisms and methods in contributions by both young and “veteran” academics, clinicians, and researchers to forward the knowledge and expertise on calcium phosphate and related materials. Accordingly, the book not only covers the fundamentals but also open new avenues for meeting future challenges in research and clinical applications. Besim Ben-Nissan is a Professor of Chemistry and Forensic Science at the University of Technology, Sydney, Australia
Bioceramics are an important class of biomaterials. Due to their desirable attributes such as biocompatibility and osseointegration, as well as their similarity in structure to bone and teeth, ceramic biomaterials have been successfully used in hard tissue applications. In this book, a team of materials research scientists, engineers, and clinicians bridge the gap between materials science and clinical commercialization providing integrated coverage of bioceramics, their applications and challenges. The book is divided into three parts. The first part is a review of classes of medical-grade ceramic materials, their synthesis and processing as well as methods of property assessment. The second part contains a review of ceramic medical products and devices developed, their evolution, their clinical applications and some of the lessons learned from decades of clinical use. The third part outlines the challenges to improve performance and the directions that novel approaches and advanced technologies are taking, to meet these challenges. With a focus on the dialogue between surgeons, engineers, material scientists, and biologists, this book is a valuable resource for researchers and engineers working toward long-lasting, reliable, customized biomedical ceramic and composites devices. - Edited by a team of experts with expertise in industry and academia - Compiles the most relevant aspects on regulatory issues, standards and engineering of bioceramic medical devices as inspired by commercial and clinical needs - Introduces bioceramics, their evolution and applications in hard tissue engineering and medical devices
