This book is a must-have for anyone interested in obesity or the physiology of white or brown adipose tissues. It contains state-of-the-art methods from researchers that are world leaders in this field. Detailed lab protocols range from methods to visualize adipocytes and adipose tissues in humans and experimental models, to convert stem cells into white and brown adipocytes in vitro, to evaluate aspects of adipocyte metabolism, to inducibly knock out genes in adipose tissues, and to evaluate transcriptional control of adipogenesis on a global scale. The study of adipose tissue goes hand in hand with our global effort to understand and reverse the epidemic of obesity and associated medical complications Contributors include leading researchers who have made tremendous contributions to our ability to investigate white and brown adipose tissues The wide variety of experimental approaches detailed within this volume: including the evaluation of adipose tissue biology at the molecular, biochemical, cellular, tissue, and organismal levels
The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.
Waisted: The Biology of Body Fat outlines the fascinating, often misunderstood and sometimes controversial biology of fat, otherwise known as adipose tissue. It provides a comprehensive, evidence-based perspective on fat biology and its crucial role in human evolution, health, disease, and society. The content draws upon biomedical, epidemiological, social and evolutionary research to understand the striking relationship between body fat distribution and health outcomes. Using digestible analogies, real-world examples and images, it highlights the multi-faceted relationship between adipose biology and society. Waisted clearly conveys the key concepts and assumptions that can lead to negative perceptions of fat, and reframes these challenges to highlight the underappreciated importance of adipose tissue in humans. Waisted is an accessible yet in-depth exploration of the subject that is suitable for both specialists and non-specialists alike. It is a highly valuable resource for clinicians, health practitioners, biomedical researchers, and students who study adipose biology, obesity, and diseases related to fat dysfunction. This book also provides an interesting sociological and anthropological read for anyone who wants to gain a broader and deeper appreciation of the unique role that adipose tissue plays in human evolution and society, by considering how biological and social factors intersect.
This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.
The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions.
Brazilian Butt Lift has been described by many, but there is no definitive resource or book that details the procedure as performed by Brazilian Plastic Surgeons. The editors conducted a recent survey among the members of the Brazilian Society of Plastic Surgeons (SBCP) and have seen that there are many differences in approach, style, technique, and even materials used between what is being done around the world and what is being done in Brazil. While addressing recent media attention and scares, this book features contributions from world renowned Brazilian and international Plastic Surgeons addressing the high morbidity and mortality recently reported and establish tried and true safety protocols. To increase the scope of the book, differing views of techniques and methods are also included, making this a truly global book covering the specific gluteal region. Gluteal Fat Augmentation: Best Practices in Brazilian Butt Lift will open with the history of the procedure, go through the anatomy and the ethnic aspects of the aesthetics of the gluteal region. The book features special chapters on gluteal fat augmentation and a wide variety of techniques to improve the gluteal contour. A wealth of images accompany the text to fully illustrate the different approaches and techniques of gluteal fat augmentation, reshaping, and contouring including the use of fillers, implants, lift, and correction of depressions and deformities of the region. Written for practicing plastic surgeons, this book is poised to become the go-to reference for cosmetic and reconstructive concerns surrounding the gluteal region.
A complete one-stop review of the clinically important aspects of histology and cell biology--user-friendly, concise, and packed with learning aids! The ideal review for course exams and the USMLE! This popular title in the LANGE series is specifically designed to help you make the most of your study time--whether you're studying histology and cell biology for the first time or reviewing for course exams or the USMLE. With this focused review you will be able to pinpoint your weak areas, and then improve your comprehension with learning aids especially designed to help you understand and retain even the most difficult material. You will find complete easy-to-follow coverage of all the need-to-know material: fundamental concepts, the four basic tissues types, and organs and organ systems--presented in a consistent, time-saving design. At the conclusion of the book, you will find a Diagnostic Final Exam that has been updated with longer, case-related stems that mimic the USMLE Step 1 examination. Each chapter is devoted to one specific topic and includes learning aids such as: Objectives that point out significant facts and concepts that you must know about each topic Max Yield(tm) study questions that direct you to key facts needed to master material most often covered on exams A synopsis presented in outline form that reviews all the basic histology and related cell biology covered on exams Multiple-choice questions written in a style most commonly used in medical school NEW to this Edition: Thoroughly revised Q&A Completely updated text and practice questions to reflect current knowledge Information added to each chapter regarding relevant pathology/clinical issues; possibly as a separate colored box Visit www.LangeTextbooks.com to access valuable resources and study aids. Thorough coverage you won't find anywhere else! FUNDAMENTAL CONCEPTS: Methods of Study, The Plasma Membrane & Cytoplasm, The Nucleus & Cell Cycle, THE FOUR BASIC TISSUE TYPES: Epithelial Tissue, Connective Tissue, Adipose Tissue, Cartilage, Bone, Integrative Multiple-Choice Questions: Connective Tissues Nerve Tissue, Muscle Tissue, Integrative Multiple-Choice Questions: Basic Tissue Types, ORGANS & ORGAN SYSTEMS: Circulatory System, Peripheral Blood, Hematopoiesis, Lymphoid System, Digestive Tract, Glands Associated with the Digestive Tract, Integrative Multiple-Choice Questions: Digestive System, Respiratory System, Skin, Urinary System, Pituitary & Hypothalamus, Adrenals, Islets of Langerhans, Thyroid, Parathyroids, & Pineal Body, Male Reproductive System, Female Reproductive System, Integrative Multiple-Choice Questions: Endocrine System, Sense Organs, Diagnostic Final Examination
This book describes in detail the multidisciplinary management of obesity, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical exercise, psychological issues, nutritional strategies, pharmacological options and bariatric surgery. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of obesity, which has rapidly become a major public health problem.
Included CD-ROM contains clinical notes, information on congenital anomalies, radiographic anatomy, and clinical problem-solving exercises, all of which correlate directly with the text.
The radical expansion and revision of techniques and experimental approaches employed in the study of adipose tissue are reflected in this revised book. Several updated chapters are combined with many new contributions from internationally recognized experts. Conventional and state-of-the-art methodologies are covered, as well as whole animal, cellular and molecular approaches which have emerged in or been extended to adipose tissue research over the past few years. This revised all-in-one manual is essential reading for newcomers to this burgeoning area as well as a valuable volume for more experienced researchers.
